Results 71 to 80 of about 78,521 (217)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Efficacy in Japanese adults with growth hormone deficiency receiving weekly somapacitan or daily growth hormone: results from phase 3 REAL 1 trial

Frontiers in Endocrinology
IntroductionSomapacitan is a long-acting growth hormone (GH) derivative approved for once-weekly treatment of adult GH deficiency (AGHD). This study aimed to evaluate the efficacy and safety of somapacitan and daily GH in Japanese individuals with AGHD ...
Fumio Otsuka, Michael Højby Rasmussen, Takaaki Endo, Claus Sværke, Shigeyuki Tahara, Gudmundur Johannsson   +5 more
doaj   +1 more source

Reported shoes size during GH therapy: is foot overgrowth a myth or reality?

Archives of Endocrinology and Metabolism, 2015
Objectives To describe population reference values for shoes size, and to identify possible disproportional foot growth during GH therapy.Materials and methods Construction of percentile chart based on 3,651 controls (male: 1,838; female: 1,813).
Débora C. F. Lago, Cláudia A. Coutinho, Cristiane Kochi, Carlos A. Longui   +3 more
doaj   +1 more source

Сompliance and barriers to growth hormone therapy in children [PDF]

, 2021
L.I. Senkіvska, M.L. Aryayev
openalex   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Isolated Growth Hormone Deficiency

Endocrines
Growth hormone deficiency (GHD) is the most frequent pituitary hormone deficiency in childhood, with an incidence of 1 in 4000–10,000 live births. GHD can be congenital (genetic or due to hypothalamic/pituitary abnormalities) or acquired and can be ...
Anastasia Ibba, Chiara Guzzetti, Lavinia Sanfilippo, Sandro Loche   +3 more
doaj   +1 more source

Growth Hormones in Broad Bean (Vicia faba L.) and Radish (Raphanus raphanistrum subsp. sativus L.) Are Associated with Accumulated Concentrations of Perfluoroalkyl Substances [PDF]

, 2023
Thimo Groffen, Niels Kuijper, Sevgi Öden, Tim Willems, Lieven Bervoets, Els Prinsen   +5 more
openalex   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Discontinuation of long-term growth hormone treatment in adults with growth hormone deficiency: a survey of UK practice

Endocrine Connections
Objective: We conducted a survey of UK endocrine clinicians between June 2022 and August 2022 to understand current practices regarding GH treatment discontinuation in adults with growth hormone deficiency.
Sherwin Criseno, Helena Gleeson, Andrew A Toogood, Neil Gittoes, Anne Topping, Niki Karavitaki   +5 more
doaj   +1 more source

6 TESTICULAR GROWTH AND HORMONAL PARAMETERS BEFORE AND AFIER SURGICAL CORRECTION OF CHILDREN AND ADOLESCENTS WITH VARICOCELE [PDF]

, 1992
Silvia Gottlieb, Miguel Luis Podestá, Maria‐Bernadette Madel, H Chemes, María Gabriela Ropelato, E. Quesada, C Bergadá   +6 more
openalex   +1 more source