Results 51 to 60 of about 5,571,602 (257)

Cardiac functions in children with growth hormone deficiency: Effects of one year of GH replacement therapy [PDF]

, 2021
Introduction: Children with Growth Hormone deficiency (GHD) are prone to heart dysfunction and, if left untreated, will result in marked cardiac dysfunction in adulthood.
Alkan, Fatos, Kızılay, Deniz Ozalp, Coşkun, Şenol, Ersoy, Betül, Ersoy B., Alkan F., Kızılay D.O., Coskun S., Betul Ersoy, Fatos Alkan, Deniz Ozalp Kızılay, Senol Coskun   +11 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Comparison of growth response and adverse reaction according to growth hormone dosing strategy for children with short stature: LG Growth Study

, 2023
Objective: Growth hormone (GH) dosage in children is conventionally determined either by body weight (BW) or body surface area (BSA). However, there is no consensus on the calculation method for proper GH treatment dose.
김호성, 서정환, 권아름, 송경철, 채현욱, 이명섭, 김수진   +6 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

A comparison of different definitions of growth response in short prepubertal children treated with growth hormone

, 2011
How to define poor growth response in the management of short growth hormone (GH)-treated children is controversial.
Tapanainen, P,, Bang, Peter,, P. Bang, Bjerknes, R., Dahlgren, J, Gustafsson, J, Bjerknes, R,, Dunkel, L,, Dunkel, L., V. Åberg, J. Gustafsson, Bang, P., Aberg, V, Bang, P,, Bang, P, Tapanainen, P., Juul, A, Kriström, Berit,, R. Bjerknes, Bjerknes, R, Gustafsson, J,, Dahlgren, J., Dahlgren, J,, Kriström, B, Kriström, B., Gustafsson, Jan,, L. Dunkel, A. Juul, Kriström, B,, Tapanainen, P, J. Dahlgren, Åberg, V., B. Kriström, P. Tapanainen, Juul, A,, Åberg, V,, Juul, A., Dunkel, L, Dahlgren, Jovanna,   +38 more
core   +1 more source

Growth hormone doping: a review

Open Access Journal of Sports Medicine, 2011
Ioulietta Erotokritou-Mulligan, Richard IG Holt, Peter H SönksenDevelopmental Origins of Health and Disease Division, University of Southampton School of Medicine, The Institute of Developmental Science, Southampton General Hospital, Southampton,
Erotokritou-Mulligan I, Holt RI, Sönksen PH   +2 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source