Results 221 to 230 of about 280,040 (307)

Once-Weekly Lonapegsomatropin Was Efficacious and Well Tolerated in Chinese Children with Growth Hormone Deficiency: Results from a Phase 3 Randomized Trial.

Horm Res Paediatr
Ying Y, Wei H, Zhong Y, Li Y, Yang Y, Li G, Gu W, Cheng X, Gong C, Xu X, Zhang H, Fu J, Yao H, Zhou L, Ge X, Li T, Zhu S, Wang Y, Li J, Li Y, Luo X.   +20 more
europepmc   +1 more source

Prevalence of Hypothalamic-Pituitary Abnormalities in Pediatric Patients with Growth Hormone Deficiency. [PDF]

Sage Open Pediatr
Sodero G, Moscogiuri LA, Lezzi M, Comes F, Passoforte P, Perrone G, Meoli A, Camporeale A, Villirillo A, Gallo F.   +9 more
europepmc   +1 more source

Effects of obesity, total fasting and realimentation on L-thyroxine (T4), 3,5,3', - L-triiodothyronine (T3), - 3,3',5'-L-triiodorhyronine (rT3), - thyroxine binding globulin (TBG), cortisol, thyrotophin, cortisol-binding globulin (CBG), transferrin, alpha2-haptoglobin and complement C 3 in serum [PDF]

, 1979
Bauer, M., Emmert, D., Fateh-Moghadam, A., Hofmann, G. G., Horn, K., Pickardt, C. R., Scriba, Peter Christian   +6 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Delphi-based Spanish consensus on the use of long-acting growth hormone in pediatric growth hormone deficiency: recommendations from the ConverGHe Working Group. [PDF]

Front Endocrinol (Lausanne)
Castro-Feijóo L, Labarta-Aizpún JI, Ramon-Krauel M, Primiano D, Yeste Fernández D, González Casado I.   +5 more
europepmc   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source

Development and Validation of a Clinical Prediction Model for Growth Hormone Deficiency in Children with Short Stature: A Retrospective Study in China. [PDF]

J Multidiscip Healthc
Li M, Liu C, Yang Y, Hu S, Li J, Qiu S, Wang Z.   +6 more
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Developing a Process for Preference Measures in Pediatric Growth Hormone Deficiency: Challenges and Solutions. [PDF]

Patient Prefer Adherence
Brod M, Pfeiffer KM, Alolga SL, Beck JF, Murphy M, Bruchey AK, Maniatis A, Pitukcheewanont P.   +7 more
europepmc   +1 more source