Results 211 to 220 of about 513,834 (341)

Glymphatic system dysfunction in pediatric growth hormone deficiency evidenced by multiple MRI metrics. [PDF]

Quant Imaging Med Surg
Huang S, Lin L, Gao X, Deng C, Qiu H, Qian L, Yang Z, Cheng Y, Chen Q, Su S.   +9 more
europepmc   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Efficacy and Safety of Once-Weekly Lonapegsomatropin in Adults With Growth Hormone Deficiency: foresiGHt Trial Results.

J Clin Endocrinol Metab
Biller BMK, Gilis-Januszewska A, Doknic M, Pico AM, Fleseriu M, Raverot G, Isidori AM, Takahashi Y, Garcia JM, Silverstein JM, Bancos I, Fukuoka H, Huang E, Kang J, Komirenko AS, Domrzalski L, Shu AD, Beckert M, Yuen KCJ.   +18 more
europepmc   +1 more source

Utility of Postoperative Thyroid Hormone Levels in Predicting the Diagnosis of Adult Growth Hormone Deficiency in Patients Undergoing Surgery for Nonfunctioning Pituitary Neuroendocrine Tumor: A Pilot Study. [PDF]

Int J Endocrinol
Tsujimoto Y, Yamashiro K, Suzuki Y, Watanabe Y, Ishii Y, Nishimura R.   +5 more
europepmc   +1 more source

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Patient and Caregiver Preferences for Once-Weekly Injection Devices for the Treatment of Growth Hormone Deficiency. [PDF]

J Endocr Soc
Chen JV, Miller BS, Kelepouris N, Kennedy C, Wayser GR, Mason B, Yuen KCJ.   +6 more
europepmc   +1 more source

Overweight/Obese adults with pituitary disorders require lower peak growth hormone cutoff values on glucagon stimulation testing to avoid overdiagnosis of growth hormone deficiency.

Journal of Clinical Endocrinology and Metabolism, 2014
L. Dichtel, K. Yuen, M. Bredella, A. Gerweck, B. Russell, Ariana D Riccio, M. Gurel, P. Sluss, B. Biller, K. Miller   +9 more
semanticscholar   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

The Impact of Growth Hormone Deficiency on Endothelial Function in Childhood Brain Cancer Survivors. [PDF]

Cancers (Basel)
Crocco M, Malerba F, Zampatti N, Nosratian V, Bigatti C, Panciroli M, Casirati A, Calevo MG, Maghnie M, Di Iorgi N.   +9 more
europepmc   +1 more source

Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances.

Endocrine reviews, 2014
K. Alatzoglou, E. Webb, P. L. Le Tissier, M. Dattani   +3 more
semanticscholar   +1 more source