Results 191 to 200 of about 513,834 (341)

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Preclinical Investigations of a Novel PEGylated Long-Acting Human Growth Hormone

Drug Design, Development and Therapy
Jun Wang,1,2 He Wang,1,2 Rong Wang,1,2 Yu Zhuang,1,2 Chenyang Jiang,1,2 Baixue Zhao,1,2 Zhen Xu,1,2 Bruce Yong Ma1,2 1Zonhon Biopharma Institute, Inc., Changzhou, Jiangsu, People’s Republic of China; 2Jiangsu Engineering Research Center for Precision ...
Wang J, Wang H, Wang R, Zhuang Y, Jiang C, Zhao B, Xu Z, Ma BY   +7 more
doaj  

Serum osteocalcin as a novel biomarker for differentiating growth hormone deficiency from idiopathic short stature. [PDF]

Front Endocrinol (Lausanne)
Wang Y, Zhou H, Wang H, Ma J, Chen X, Yang H, Zheng H, Wang A.   +7 more
europepmc   +1 more source

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

Advanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao, Xin Wang, Jing Zhang, Ryan McQuinn, Je Min Lee, Itay Gonda, Ari Feder, Yimin Xu, Baike Wang, Qinghui Yu, Denise M. Tieman, Sanwen Huang, Harry Klee, James J. Giovannoni, Zhangjun Fei   +14 more
wiley   +1 more source

Growth hormone retesting for idiopathic isolated growth hormone deficiency during and after puberty: a systematic review. [PDF]

J Endocr Soc
Vliegenthart J, Wols DF, Wit JM, Bramer W, Rings EHHM, van den Akker ELT, van der Kaay DCM.   +6 more
europepmc   +1 more source

Controversies in the diagnosis and management of growth hormone deficiency in childhood and adolescence

Archives of Disease in Childhood, 2015
Philip G. Murray, Philip G. Murray, M. Dattani, M. Dattani, Peter E. Clayton, Peter E. Clayton   +5 more
semanticscholar   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Final adult height in Korean children with idiopathic growth hormone deficiency after growth hormone treatment. [PDF]

Sci Rep
Cho MH, An SJ, Shim YS, Hwang JS, Lee HS.   +4 more
europepmc   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Growth hormone deficiency in three siblings homozygous for a rare <i>GH1</i> haplotype. [PDF]

Front Endocrinol (Lausanne)
Ribeiro AC, Omar OM, Abdalla E, Lemos MC.   +3 more
europepmc   +1 more source