Results 41 to 50 of about 273,591 (356)
Pituitary-adrenal axis in Prader Willi syndrome [PDF]
, 2016 Purpose: Prader Willi syndrome (PWS) is a rare genetic condition that has concurrent endocrinological insufficiencies. The presence of growth hormone deficiency has been well documented, but adrenal insufficiency (AI) is not widely reported. A review was
Edgar, Olivia S. +2 more
core +2 more sources
Anales de Pediatría, 2018 Resumen: Introducción: La hormona de crecimiento humana recombinante biosimilar (rhGH) fue el primer medicamento autorizado por la Agencia Europea del Medicamento (EMA), en el año 2006, por la vía de registro biosimilar.
Juan Pedro López-Siguero +4 more
doaj +1 more source
Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength [PDF]
, 2015 Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice
Chavassieux, P +10 more
core +1 more source
Efficacy of growth hormone therapy in adults with childhood-onset growth hormone deficiency [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 PurposeGrowth hormone (GH) plays a key role in the regulation of body composition, lipid metabolism, and quality of life in adults with GH deficiency (GHD).
Ja Hye Kim +3 more
doaj +1 more source
Differential Tissue Response to Growth Hormone in Mice [PDF]
, 2018 Growth hormone (GH) has been shown to act directly on multiple tissues throughout the body. Historically, it was believed that GH acted directly in the liver and only indirectly in other tissues via insulin‐like growth hormone 1 (IGF‐1).
Banerjee, Ronadip R. +4 more
core +2 more sources
Isolated Growth Hormone Deficiency
EndocrinesGrowth hormone deficiency (GHD) is the most frequent pituitary hormone deficiency in childhood, with an incidence of 1 in 4000–10,000 live births. GHD can be congenital (genetic or due to hypothalamic/pituitary abnormalities) or acquired and can be ...
Anastasia Ibba +3 more
doaj +1 more source
Aetiology of growth hormone deficiency. [PDF]
Archives of Disease in Childhood, 1987 A retrospective analysis was performed in an attempt to identify perinatal risk factors for the development of growth hormone deficiency. More of the affected children were boys, and their birth weights were significantly lower than those of the national average; there were also considerably more preterm and post-term deliveries among boys.
S M Herber, R Kay
openaire +3 more sources
Hypothalamic lipoma and growth hormone deficiency [PDF]
International Journal of Pediatric Endocrinology, 2020 AbstractBackgroundIntracranial lipomas are rare, congenital lesions, most often located at the midline. Most hypothalamic lipomas are asymptomatic, but some cases have been associated with precocious puberty, hypothermia, headache and/or obesity.Case presentationA 7-year-old boy was referred for short stature and proved to be partially growth-hormone ...
Rochtus, Anne +2 more
openaire +4 more sources
Human Pancreas GH-Releasing Factor Analog Restores High-Amplitude GH Pulses in CNS Lesion-Induced GH Deficiency [PDF]
, 1983 Lesions of the ventromedial-arcuate (VMH-ARC) region of the hypothalamus result in impaired growth accompanied by a marked suppression in spontaneous GH secretory bursts. We studied the effects of an analog of the recently characterized human pancreas GH-
Eikelboom, Rudy +2 more
core +2 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source