Effects of cholinergic antagonists on ghrelin release and expression in the crop, proventriculus, and duodenum of newly hatched chickens. [PDF]
Scanes CG+2 more
europepmc +1 more source
Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I.
Punt LD+28 more
europepmc +1 more source
Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice.
Poelman R+4 more
europepmc +1 more source
Growth Hormone Secretagogue Receptor Family Members and Ligands [PDF]
We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of the growth hormone-releasing peptides (GHRPs) and nonpeptide ligands such as L-692,429 and MK-0677.
Roy G. Smith+9 more
openaire +2 more sources
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The Growth Hormone Secretagogue Receptor (Ghs-R)
Current Pharmaceutical Design, 2012The growth hormone secretagogue receptor (GHS-R) is a component of the ghrelin signaling pathway and is involved in mediating the pleiotropic effects of ghrelin. Two isoforms have been identified, but only GHS-R1a binds with acyl ghrelin and transduces its message.
LAVIANO, Alessandro+3 more
openaire +4 more sources
Molecular Characterization of Growth Hormone Secretagogue Receptors [PDF]
The synthetic hexapeptide growth hormone releasing peptide 6 (GHRP-6) mediates growth hormone (GH) release from primary pituitary cells through a distinct mechanism from that controlled by growth hormone releasing hormone (GHRH) or somatostatin (1–3).
Andrew D. Howard+3 more
openaire +1 more source
The Growth Hormone Secretagogue Receptor
2007The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
openaire +2 more sources
Growth Hormone–Releasing Hormone and Growth Hormone Secretagogue-Receptor Ligands
Endocrine, 2001Growth hormone-releasing hormone (GHRH) and somatostatin are the most important hypothalamic neurohormones controlling growth hormone (GH) secretion. Several neurotransmitters and neuropeptides also play an important role in the control of GH secretion, mainly acting via modulation of GHRH and somatostatin. In the past two decades, particular attention
ARVAT, Emanuela+10 more
openaire +5 more sources
Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor
Biochemical and Biophysical Research Communications, 2000The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic extracts and assayed fractions for activity on HEK293 cells expressing GHS-R and aequorin.
Yuan Xu+15 more
openaire +3 more sources
A relationship between motilin and growth hormone secretagogue receptors
Regulatory Peptides, 2012The motilin receptor (MR) belongs to a family of Class I G protein-coupled receptors that also includes growth hormone secretagogue receptor (GHSR). Their potentially unique structure and the molecular basis of their binding and activation are not yet clear.
Morikazu Onji+10 more
openaire +3 more sources