Results 201 to 210 of about 11,206 (235)

Heterogeneity of Ghrelin/Growth Hormone Secretagogue Receptors

Neuroendocrinology, 2007
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the type 1a GH secretagogue receptor (GHS-R1a) located in the hypothalamus-pituitary axis. GHS-R1a is a G-protein-coupled receptor that, upon the binding of ghrelin or synthetic peptidyl and non-peptidyl ghrelin-mimetic agents known as GHS, preferentially couples ...
Giampiero Muccioli, Alessandra Baragli, Riccarda Granata, Mauro Papotti, Ezio Ghigo   +4 more
openaire   +1 more source

Glucocorticoids Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression

Journal of Neuroendocrinology, 2000
AbstractGlucocorticoids regulate growth hormone (GH) secretion by modulating both hypothalamic and pituitary function. At the level of the pituitary, glucocorticoids increase GH and GH‐releasing hormone receptor (GHRH‐R) gene expression. To test if glucocorticoids might also regulate the pituitary expression of the recently identified GH secretagogue ...
H, Tamura, J, Kamegai, H, Sugihara, R D, Kineman, L A, Frohman, I, Wakabayashi   +5 more
openaire   +2 more sources

Molecular characterization of chicken growth hormone secretagogue receptor gene

General and Comparative Endocrinology, 2003
Synthetic growth hormone secretagogues stimulate growth hormone secretion by binding to a specific receptor, growth hormone secretagogue receptor (GHS-R). In this study, we investigated the cDNA and the genomic structure of chicken GHS-R. Chicken GHS-R gene is composed of two exons separated by an intron.
Minoru, Tanaka, Takashi, Miyazaki, Ichiro, Yamamoto, Naoya, Nakai, Yoshiyuki, Ohta, Nobumichi, Tsushima, Masaaki, Wakita, Kiyoshi, Shimada   +7 more
openaire   +2 more sources

A relationship between motilin and growth hormone secretagogue receptors

Regulatory Peptides, 2012
The motilin receptor (MR) belongs to a family of Class I G protein-coupled receptors that also includes growth hormone secretagogue receptor (GHSR). Their potentially unique structure and the molecular basis of their binding and activation are not yet clear.
Hiroaki, Nunoi, Bunzo, Matsuura, Sachiko, Utsunomiya, Teruhisa, Ueda, Teruki, Miyake, Shinya, Furukawa, Teru, Kumagi, Yoshiou, Ikeda, Masanori, Abe, Yoichi, Hiasa, Morikazu, Onji   +10 more
openaire   +2 more sources

Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor

Biochemical and Biophysical Research Communications, 2000
The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic extracts and assayed fractions for activity on HEK293 cells expressing GHS-R and aequorin.
R G, Smith, P R, Griffin, Y, Xu, A G, Smith, K, Liu, J, Calacay, S D, Feighner, C, Pong, D, Leong, A, Pomés, K, Cheng, L H, Van der Ploeg, A D, Howard, J, Schaeffer, R J, Leonard   +14 more
openaire   +2 more sources

Molecular Characterization of Growth Hormone Secretagogue Receptors

2000
The synthetic hexapeptide growth hormone releasing peptide 6 (GHRP-6) mediates growth hormone (GH) release from primary pituitary cells through a distinct mechanism from that controlled by growth hormone releasing hormone (GHRH) or somatostatin (1–3).
Andrew D. Howard, Scott D. Feighner, Roy G. Smith, Lex H. T. Van der Ploeg   +3 more
openaire   +1 more source

Distribution and regulation of chicken growth hormone secretagogue receptor isoforms

General and Comparative Endocrinology, 2003
Chicken ghrelin has recently been isolated as a hormone which stimulates growth hormone and corticosterone secretion in chicken. Ghrelin mediates these actions in mammals by binding to the growth hormone secretagogue receptor (GHS-R). In this study, we describe the partial cloning of two chicken GHS-R (cGHS-R) isoforms: cGHS-R1a and cGHS-R1c.
S M E, Geelissen, I M E, Beck, V M, Darras, E R, Kühn, S, Van der Geyten   +4 more
openaire   +2 more sources

Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Journal of Medicinal Chemistry, 2006
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories have been shown to be dihydrofolate reductase (DHFR) inhibitors.
Zhili, Xin, Michael D, Serby, Hongyu, Zhao, Christi, Kosogof, Bruce G, Szczepankiewicz, Mei, Liu, Bo, Liu, Charles W, Hutchins, Kathy A, Sarris, Ethan D, Hoff, H Douglas, Falls, Chun W, Lin, Christopher A, Ogiela, Christine A, Collins, Michael E, Brune, Eugene N, Bush, Brian A, Droz, Thomas A, Fey, Victoria E, Knourek-Segel, Robin, Shapiro, Peer B, Jacobson, David W A, Beno, Teresa M, Turner, Hing L, Sham, Gang, Liu   +24 more
openaire   +2 more sources

Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands

2004
The discovery of ghrelin is a typical example of reverse pharmacology: first the synthetic analogues (i.e. peptidyl and non-peptidyl growth hormone secretagogues (GHS)); second the receptor; third the natural ligand for this orphan receptor, i.e. ghrelin. Ghrelin is providing new understanding about how the gastrointestinal tract and nutritional intake
MUCCIOLI, Giampiero, BROGLIO, Fabio, Tarabra E., GHIGO, Ezio   +3 more
openaire   +2 more sources

Ghrelin- and growth hormone secretagogue receptor-immunoreactive cells in Xenopus pancreas

Regulatory Peptides, 2011
Ghrelin and its receptor, growth hormone secretagogue receptor (GHS-R), are produced by various cell types and affect feeding behavior, metabolic regulation, and energy balance. In the mammalian pancreas, the types of endocrine cells immunoreactive for ghrelin vary. Further, no study has clarified the type of endocrine cells producing ghrelin and GHS-R
Hirohumi, Suzuki, Toshiharu, Yamamoto
openaire   +2 more sources