Results 1 to 10 of about 2,692,169 (258)
Ghrelin receptors in non-mammalian vertebrates [PDF]
Frontiers in Endocrinology, 2013 The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya +2 more
doaj +4 more sources
Molecular evolution of GPCRs: Ghrelin/ghrelin receptors. [PDF]
Journal of Molecular Endocrinology, 2014 After the discovery in 1996 of the GH secretagogue-receptor type-1a (GHS-R1a) as an orphan G-protein coupled receptor, many research groups attempted to identify the endogenous ligand. Finally, Kojima and colleagues successfully isolated the peptide ligand from rat stomach extracts, determined its structure, and named it ghrelin.
H. Kaiya, K. Kangawa, M. Miyazato
semanticscholar +3 more sources
Novel and Conventional Receptors for Ghrelin, Desacyl-Ghrelin, and Pharmacologically Related Compounds [PDF]
Pharmacological Reviews, 2014 The only molecularly identified ghrelin receptor is the growth hormone secretagogue receptor GHSR1a. Its natural ligand, ghrelin, is an acylated peptide whose unacylated counterpart (UAG) is almost inactive at GHSR1a. A truncated, nonfunctional receptor, GHSR1b, derives from the same gene.
B. Callaghan, J. Furness
semanticscholar +4 more sources
The complex signaling pathways of the Ghrelin receptor.
Endocrinology, 2020 The ghrelin receptor (GhrR) is known for its strong orexigenic effects in pharmacological doses and has long been considered as a promising target for the treatment of obesity.
M. Hedegaard, B. Holst
semanticscholar +5 more sources
LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor [PDF]
Cell Metabolism, 2018 Ghrelin, an appetite-stimulatory hormone secreted by the stomach, was discovered as a ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin stimulates growth hormone (GH) secretion, a function that evolved to protect against starvation-induced hypoglycemia.
Lutz Jermutus +2 more
exaly +3 more sources
Hypothalamic ghrelin receptors, weight loss, and glycemia in an experimentally induced obesity model treated by sleeve gastrectomy [PDF]
Acta Cirúrgica BrasileiraPurpose: Body weight, blood glucose, and hypothalamic ghrelin receptors were monitored in an animal model of obesity after being treated with sleeve gastrectomy.
Claudia Gissi da Rocha Ferreira +4 more
doaj +2 more sources
Role of Dopaminergic and Cannabinoidergic Receptors on Ghrelin-Induced Hypophagia in 5-Day-Old Broiler Chicken [PDF]
Archives of Razi Institute, 2021 The present study aimed to identify the role of dopaminergic and cannabinoidergic systems in the ghrelin-induced hypophagia among meat-type chickens.
R Farrokhi +4 more
doaj +1 more source
Aquaculture Reports, 2023 Ghrelin has been well known as an orexigenic hormone that regulates appetite and energy metabolism in animals. Recent studies imply the regulatory function of ghrelin on ovary development, however, the mechanism about the effects of ghrelin on key ...
Jiamin Pi +7 more
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The Links of Ghrelin to Incretins, Insulin, Glucagon, and Leptin After Bariatric Surgery
Frontiers in Genetics, 2021 Type 2 diabetes mellitus (T2DM) is one of the most prominent and socially significant problems. The present study aimed to identify the mechanisms of interaction of critical regulators of carbohydrate metabolism using bioinformatics and experimental ...
Daria Skuratovskaia +7 more
doaj +1 more source
Role of Central Cannabinoidergic System on Ghrelin-Induced Hypophagia in Layer-Type Neonatal Chicken [PDF]
Iranian Journal of Veterinary Medicine, 2019 Background: Feeding behavior is regulated via a complex network which interacts through diverse signals from central and peripheral tissues. OBJECTIVES: The main purpose of the current study was to determine the role of central cannabinoidergic (CBergic)
Mohammadreza Taherian +2 more
doaj +1 more source