Results 11 to 20 of about 2,692,169 (258)

Ghrelin and oral diseases

Central European Journal of Immunology, 2021
Eating food is one of the most complicated behaviours in mammals, especially humans. The primary function of ghrelin is regulation of the appetite level and its stimulation.
Sylwia Małgorzata Słotwińska
doaj   +1 more source

Ghrelin and ghrelin receptor modulation of psychostimulant action [PDF]

Frontiers in Neuroscience, 2013
Ghrelin (GHR) is an orexigenic gut peptide that modulates multiple homeostatic functions including gastric emptying, anxiety, stress, memory, feeding, and reinforcement. GHR is known to bind and activate growth-hormone secretagogue receptors (termed GHR-Rs).
Wellman, Paul J., Clifford, P. Shane, Rodriguez, Juan A.   +2 more
openaire   +3 more sources

Concomitant release of ventral tegmental acetylcholine and accumbal dopamine by ghrelin in rats. [PDF]

PLoS ONE, 2012
Ghrelin, an orexigenic peptide, regulates energy balance specifically via hypothalamic circuits. Growing evidence suggest that ghrelin increases the incentive value of motivated behaviours via activation of the cholinergic-dopaminergic reward link.
Elisabet Jerlhag, Anna Carin Janson, Susanna Waters, Jörgen A Engel   +3 more
doaj   +1 more source

GABAB Receptor Blockade Prevents Antiepileptic Action of Ghrelin in the Rat Hippocampus [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Zohreh Ataie, Shirin Babri, Mina Ghahramanian Golzar, Hadi Ebrahimi, Fariba Mirzaie, Gisou Mohaddes   +5 more
doaj   +1 more source

Molecular mechanism of agonism and inverse agonism in ghrelin receptor

Nature Communications, 2022
Much effort has been invested in the investigation of the structural basis of G protein-coupled receptors (GPCRs) activation. Inverse agonists, which can inhibit GPCRs with constitutive activity, are considered useful therapeutic agents, but the ...
Jiao Qin, Ye Cai, Zheng Xu, Q. Ming, Su-Yu Ji, Chao Wu, Huibing Zhang, C. Mao, D. Shen, K. Hirata, Yanbin Ma, Wei Yan, Yan Zhang, Zhenhua Shao   +13 more
semanticscholar   +1 more source

NPY Receptors Blockade Prevents Anticonvulsant Action of Ghrelin in the Hippocampus of Rat [PDF]

Advanced Pharmaceutical Bulletin, 2013
Purpose: Ghrelin has been shown to have antiepileptic function. However, the underlying mechanisms by which, ghrelin exerts its antiepileptic effects are still unclear.
Mina Ghahramanian Golzar, Shirin Babri, Zohre Ataie, Hadi Ebrahimi, Fariba Mirzaie, Gisou Mohaddes   +5 more
doaj   +1 more source

Mechanisms of Ghrelin anti-heart failure: inhibition of Ang II-induced cardiomyocyte apoptosis by down-regulating AT1R expression. [PDF]

PLoS ONE, 2014
BACKGROUND: Ghrelin is a novel growth hormone-releasing peptide administered to treat chronic heart failure (CHF). However, the underlying mechanism of its protective effects against heart failure (HF) remains unclear.
Chunyan Yang, Zhonghui Liu, Kai Liu, Ping Yang   +3 more
doaj   +1 more source

Relationship Between Circulating Metabolic Hormones and Their Central Receptors During Ovariectomy-Induced Weight Gain in Rats

Frontiers in Physiology, 2022
Although increasing research focuses on the phenomenon of body weight gain in women after menopause, the complexity of body weight regulation and the array of models used to investigate it has proven to be challenging.
Kaitlin E. Burch, Kelly McCracken, Daniel J. Buck, Randall L. Davis, Dusti K. Sloan, Kathleen S. Curtis   +5 more
doaj   +1 more source

A ghrelin receptor antagonist reduces the ability of ghrelin, alcohol or amphetamine to induce a dopamine release in the ventral tegmental area and in nucleus accumbens shell in rats.

European Journal of Pharmacology, 2021
The orexigenic peptide ghrelin increases the release of dopamine in the nucleus accumbens (NAc) shell via central ghrelin receptors, especially those located in the ventral tegmental area (VTA).
C. Edvardsson, Jesper Vestlund, E. Jerlhag   +2 more
semanticscholar   +1 more source

Physiological roles revealed by ghrelin and ghrelin receptor deficient mice [PDF]

Peptides, 2011
Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection.
Rosie G, Albarran-Zeckler, Yuxiang, Sun, Roy G, Smith   +2 more
openaire   +2 more sources