Results 21 to 30 of about 2,692,169 (258)

Ghrelin and motilin receptors as drug targets for gastrointestinal disorders

Nature Reviews Gastroenterology &Hepatology, 2016
The gastrointestinal tract is the major source of the related hormones ghrelin and motilin, which act on structurally similar G protein-coupled receptors. Nevertheless, selective receptor agonists are available.
G. Sanger, J. Furness
semanticscholar   +1 more source

Caloric restriction stimulates autophagy in rat cortical neurons through neuropeptide Y and ghrelin receptors activation

Aging, 2016
Caloric restriction is an anti-aging intervention known to extend lifespan in several experimental models, at least in part, by stimulating autophagy. Caloric restriction increases neuropeptide Y (NPY) in the hypothalamus and plasma ghrelin, a peripheral
M. Ferreira-Marques, C. Aveleira, S. Carmo-Silva, M. Botelho, L. P. de Almeida, C. Cavadas   +5 more
semanticscholar   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

Periodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti, Jean E. Suvan, Francesco D'Aiuto   +2 more
wiley   +1 more source

Investigation of the Effects of Ghrelin and Kisspeptin Levels in Liver Tissue of Rats Fed with High Fructose Diet -A Histological Study

Ahi Evran Medical Journal, 2023
Purpose: High fructose corn syrup (HFCS) is used commonly in the food industry and has been associated with various diseases including obesity, diabetes and fatty liver.
Ahmet TÜRK, Abdullah KARADAĞ, Büşra ZENCİRCİ, Yusuf ÖZAY, Osman GÜLER   +4 more
doaj   +1 more source

Antinociceptive Effect of Ghrelin in a Rat Model of Irritable Bowel Syndrome Involves TRPV1/Opioid Systems

Cellular Physiology and Biochemistry, 2017
Background/Aims: Irritable bowel syndrome (IBS), defined as recurrent abdominal pain and changes in bowel habits, seriously affects quality of life and ability to work.
Yuqing Mao, Zhengyang Li, Kan Chen, Huafang Yu, Shaoren Zhang, Miao Jiang, Yuanhua Ma, Chunli Liang, Hongyan Liu, Huanqing Li, Qian Hua, Hao Zhou, Yonghong Sun, Xiaoming Fan   +13 more
doaj   +1 more source

The immunohistochemical presence and distribution of ghrelin, apelin and their receptors in dog ovaries

Microbiology Research, 2017
The activity of ghrelin, apelin and their receptors has been correlated to the control of some infectious diseases, besides the hypothesis of their role in the control of some peripheral organs, among which ovaries.
Carolina Pirino, Margherita Maranesi, Angela Polisca, Alessandro Troisi, Cecilia Dall'Aglio   +4 more
doaj   +1 more source

Ghrelin-mediated inhibition of the TSH-stimulated function of differentiated human thyrocytes ex vivo. [PDF]

PLoS ONE, 2017
Ghrelin is a peptide hormone produced mainly in the gastrointestinal tract known to regulate several physiological functions including gut motility, adipose tissue accumulation and hunger sensation leading to increased bodyweight.
Maria Barington, Marianne Møller Brorson, Jacob Hofman-Bang, Åse Krogh Rasmussen, Birgitte Holst, Ulla Feldt-Rasmussen   +5 more
doaj   +1 more source

Why is motilin active in some studies with mice, rats, and guinea pigs, but not in others? Implications for functional variability among rodents

Pharmacology Research & Perspectives, 2022
The gastrointestinal (GI) hormone motilin helps control human stomach movements during hunger and promotes hunger. Although widely present among mammals, it is generally accepted that in rodents the genes for motilin and/or its receptor have undergone ...
Gareth J. Sanger
doaj   +1 more source

Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway

Cell Communication and Signaling, 2019
Background Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear.
Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li, Gangyi Yang   +10 more
doaj   +1 more source

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

Diabetes, 2013
Growth hormone secretagogue receptors (GHSRs) in the central nervous system (CNS) mediate hyperphagia and adiposity induced by acyl ghrelin (AG). Evidence suggests that des-AG (dAG) has biological activity through GHSR-independent mechanisms. We combined
K. Heppner, C. L. Piechowski, A. Müller, Nickki Ottaway, Stephanie Sisley, D. Smiley, K. Habegger, P. Pfluger, R. DiMarchi, H. Biebermann, M. Tschöp, D. Sandoval, D. Perez-Tilve   +12 more
semanticscholar   +1 more source