Results 31 to 40 of about 2,692,169 (258)

Ghrelin, via corticotropin‐releasing factor receptors, reduces glucose uptake and increases lipid content in mouse myoblasts cells

Physiological Reports, 2021
Ghrelin and the corticotropin‐releasing factor (CRF) family are known regulators of cellular metabolism and energy balance. We previously demonstrated that myoblast glucose metabolism is regulated by ghrelin and that this effect is mediated by CRF ...
Michal Elbaz, Eran Gershon
doaj   +1 more source

Cannabinoids enhance gastric X/A-like cells activity.

Folia Histochemica et Cytobiologica, 2008
It has been reported that cannabinoids may cause overeating in humans and in laboratory animals. Although, endogenous cannabinoids and their receptors (CB1) have been found in the hypothalamus, and recently also in gastrointestinal tract, the precise ...
Bogusław Sawicki, Robert Lukasz Zbucki, Anna Hryniewicz, Maria Małgorzata Winnicka   +3 more
doaj   +1 more source

Ghrelin cell–expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin

JCI Insight, 2021
Mechanisms underlying postprandial and obesity-associated plasma ghrelin reductions are incompletely understood. Here, using ghrelin cell–selective insulin receptor–KO (GhIRKO) mice, we tested the impact of insulin, acting via ghrelin cell–expressed ...
Kripa Shankar, Shota Takemi, Deepali Gupta, Salil Varshney, Bharath K. Mani, Sherri Osborne-Lawrence, Nathan P. Metzger, Corine P. Richard, Eric D. Berglund, Jeffrey M. Zigman   +9 more
doaj   +1 more source

Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet

Frontiers in Cellular Neuroscience, 2021
There is evidence of ghrelinergic-cannabinoidergic interactions in the central nervous system (CNS) that may impact on the plasticity of reward circuits. The aim of this article was to look for molecular and/or functional interactions between cannabinoid
Alejandro Lillo, Jaume Lillo, Jaume Lillo, Iu Raïch, Cristina Miralpeix, Cristina Miralpeix, Francesc Dosrius, Rafael Franco, Rafael Franco, Rafael Franco, Gemma Navarro, Gemma Navarro, Gemma Navarro   +12 more
doaj   +1 more source

The role of leptin and ghrelin in the regulation of appetite in obesity.

Peptides
Leptin and ghrelin are two key hormones that play opposing roles in the regulation of appetite and energy balance. Ghrelin stimulates appetite and food intake following binding to receptors and the subsequent activation of orexigenic neurons in the ...
K. Skoracka, S. Hryhorowicz, Piotr Schulz, A. Zawada, A. E. Ratajczak-Pawłowska, A. Rychter, R. Słomski, A. Dobrowolska, I. Krela-kaźmierczak   +8 more
semanticscholar   +1 more source

Association Studies on Ghrelin and Ghrelin Receptor Gene Polymorphisms With Obesity [PDF]

Obesity, 2009
Ghrelin exerts a stimulatory effect on appetite and regulates energy homeostasis. Ghrelin gene variants have been shown to be associated with metabolic traits, although there is evidence suggesting linkage and association with obesity and the ghrelin receptor (GHSR).
Gueorguiev, Maria, Lecoeur, Cécile, Meyre, David, Benzinou, Michael, Mein, Charles A., Hinney, Anke, Vatin, Vincent, Weill, Jacques, Heude, Barbara, Hebebrand, Johannes, Grossman, Ashley B., Korbonits, Márta, Froguel, Philippe   +12 more
openaire   +4 more sources

Ghrelin receptor in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica)

Frontiers in Endocrinology, 2011
We identified cDNA encoding a functional growth hormone secretagogue-receptor 1a (GHS-R1a, ghrelin receptor) in two species of anuran amphibian, bullfrog (Rana catesbeiana) and Japanese tree frog (Hyla japonica). Deduced receptor protein for bullfrog and
Hiroyuki eKaiya, Yasushi eKoizumi, Norifumi eKonno, Kazutoshi eYamamoto, Minoru eUchiyama, Kenji eKangawa, Mikiya eMiyazato   +6 more
doaj   +1 more source

The hungry stomach: physiology, disease and drug development opportunities

Frontiers in Pharmacology, 2011
During hunger, a series of high-amplitude contractions of the stomach and small intestine (phase III), which form part of a cycle of quiescence and contractions (known as the migrating motor complex; MMC), play a ‘housekeeping’ role prior to the next ...
Gareth J Sanger, Per M Hellström, Erik eNäslund   +2 more
doaj   +1 more source

The Physiological Role of Ghrelin in the Regulation of Energy and Glucose Homeostasis

Cureus, 2020
Ghrelin is a peptide hormone that is primarily released from the stomach. It is best known for its role in appetite initiation. However, evidence also suggests that ghrelin may play a much wider role in energy homeostasis and glucose metabolism.
Alina Sovetkina, R. Nadir, J. Fung, Ashkan Nadjarpour, Benjamin Beddoe   +4 more
semanticscholar   +1 more source

Structure and Physiological Actions of Ghrelin

Scientifica, 2013
Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
doaj   +1 more source