Results 211 to 220 of about 60,269 (268)

The unexpected loss of the 'hunger hormone' ghrelin in true passerines: a game changer in migration physiology. [PDF]

R Soc Open Sci
Prost S, Elbers JP, Slezacek J, Hykollari A, Fuselli S, Smith S, Fusani L.   +6 more
europepmc   +1 more source

The Pathologic Roles and Therapeutic Implications of Ghrelin/GHSR System in Mental Disorders. [PDF]

Depress Anxiety
Mao Q, Wang J, Yang Z, Ding R, Lv S, Ji X.   +5 more
europepmc   +1 more source

Loss-of-Function GHSR Variants Are Associated With Short Stature and Low IGF-I.

J Clin Endocrinol Metab
Punt LD, Kooijman S, Mutsters NJM, Yue K, van der Kaay DCM, van Tellingen V, Bakker-van Waarde WM, Boot AM, van den Akker ELT, van Boekholt AA, de Groote K, Kruijsen AR, van Nieuwaal-van Maren NHG, Woltering MC, Heijligers M, van der Heyden JC, Bannink EMN, Rinne T, Hannema SE, de Waal WJ, Delemarre LC, Rensen PCN, de Bruin C, van Duyvenvoorde HA, Visser JA, Delhanty PJD, Losekoot M, Wit JM, Joustra SD.   +28 more
europepmc   +1 more source

Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice.

Endocrinology
Poelman R, Le May MV, Schéle E, Stoltenborg I, Dickson SL.   +4 more
europepmc   +1 more source

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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor

Trends in Endocrinology & Metabolism, 2001
Growth hormone (GH) secretagogues (GHSs) are small synthetic molecules that act through a specific G-protein-coupled receptor (GPCR) called GHS-R. Until the recent identification of 'ghrelin' from rat and human stomachs, GHS-R was an orphan receptor (i.e. had no known natural ligand).
Hisayuki Matsuo, Masayasu Kojima, Kenji Kangawa, Hiroshi Hosoda   +3 more
openaire   +4 more sources

Growth Hormone Secretagogue Receptor Family Members and Ligands [PDF]

Endocrine, 2001
We have previously reported the cloning and characterization of a new orphan G-protein-coupled receptor (GPC-R), the growth hormone secretagogue receptor (GHS-R), and shown that this receptor mediates the activity of the growth hormone-releasing peptides (GHRPs) and nonpeptide ligands such as L-692,429 and MK-0677.
Roy G. Smith, Alex R. T. Bailey, Carina P. Tan, Andrew D. Howard, Oksana C. Palyha, Patrick R. Griffin, Reid J. Leonard, Karen K. McKee, Sheng-Shung Pong, Scott D. Feighner   +9 more
openaire   +2 more sources

The Growth Hormone Secretagogue Receptor (Ghs-R)

Current Pharmaceutical Design, 2012
The growth hormone secretagogue receptor (GHS-R) is a component of the ghrelin signaling pathway and is involved in mediating the pleiotropic effects of ghrelin. Two isoforms have been identified, but only GHS-R1a binds with acyl ghrelin and transduces its message.
LAVIANO, Alessandro, MOLFINO, ALESSIO, Serena Rianda, ROSSI FANELLI, Filippo   +3 more
openaire   +4 more sources

Stimulation of endogenous pulsatile growth hormone secretion by activation of growth hormone secretagogue receptor reduces the fat accumulation and improves the insulin sensitivity in obese mice

The FASEB Journal, 2020
Obese individuals often show low growth hormone (GH) secretion, which leads to reduced lipid mobilization and further fat accumulation. Pharmacological approaches to increase GH levels in obese individuals by GH injection or GH‐releasing hormone receptor
Zhengxiang Huang, Xuehan Lu, Li-li Huang, Chunhong Zhang, J. Veldhuis, M. Cowley, Chen Chen   +6 more
semanticscholar   +1 more source

Molecular Characterization of Growth Hormone Secretagogue Receptors [PDF]

, 2000
The synthetic hexapeptide growth hormone releasing peptide 6 (GHRP-6) mediates growth hormone (GH) release from primary pituitary cells through a distinct mechanism from that controlled by growth hormone releasing hormone (GHRH) or somatostatin (1–3).
Andrew D. Howard, Roy G. Smith, Lex H.T. Van der Ploeg, Scott D. Feighner   +3 more
openaire   +1 more source

Growth hormone secretagogue receptor signalling affects high‐fat intake independently of plasma levels of ghrelin and LEAP2, in a 4‐day binge eating model

Journal of neuroendocrinology, 2019
The growth hormone secretagogue receptor (GHSR) is a G protein‐coupled receptor that is highly expressed in the central nervous system. GHSR acts as a receptor for ghrelin and for liver‐expressed antimicrobial peptide 2 (LEAP2), which blocks ghrelin ...
M. Cornejo, Daniel Castrogiovanni, H. Schiöth, Mirta Reynaldo, J. Marie, J. Fehrentz, M. Perelló   +6 more
semanticscholar   +1 more source