Results 211 to 220 of about 10,555 (248)

Growth hormone secretagogue receptor antagonists

Expert Opinion on Therapeutic Patents, 2012
The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
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On the use of cells or membranes for receptor binding: Growth hormone secretagogues

Analytical Biochemistry, 2010
Receptor binding techniques have been widely used in different biochemical applications, with isolated membranes being the most used receptor preparation in this type of assays. In this study, intact cells were compared with isolated membranes as receptor support for radioligand receptor binding assay.
Zoran Nikolovski, Jordi Segura, Armand Pinyot, Ricardo Gutiérrez-Gallego, Jaume Bosch   +4 more
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Analysis of polymorphism of growth hormone secretagogue receptor in goat

Indian Journal of Animal Research, 2018
Two pairs of primers (GHSR-3, GHSR-4) were used to amplify GHSR gene of Boer goat, Yaoshan goat and black goat. Totally two mutation sites (SNP loci), G200A and T628C were detected in amplification fragments of GHSR-3 and GHSR-4 respectively. For locus G200A, allele frequencies of G and A in Yaoshan goat, Boer goat and black goat were 0.637/0.595/0.827
X. Wang, Shuai Yang, G. L. Li, Jun Yan Bai, You Bing Yang, Y. G. Zhao   +5 more
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Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands

2004
The discovery of ghrelin is a typical example of reverse pharmacology: first the synthetic analogues (i.e. peptidyl and non-peptidyl growth hormone secretagogues (GHS)); second the receptor; third the natural ligand for this orphan receptor, i.e. ghrelin. Ghrelin is providing new understanding about how the gastrointestinal tract and nutritional intake
MUCCIOLI, Giampiero, BROGLIO, Fabio, Tarabra E., GHIGO, Ezio   +3 more
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Characterization of a Monoclonal Antibody Specific for the Growth Hormone Secretagogue Receptor

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017
Ghrelin is an orexigenic peptide hormone that primarily regulates growth hormone secretion, food intake, and energy homeostasis. It has been shown to also play a role in numerous higher brain functions, such as the regulation of inflammation and cell proliferation. Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR), a G-
K. Crotta, C. Casnici, N. Tonna, D. Lattuada, F. Bianco, O. Marelli   +5 more
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Molecular characterization of chicken growth hormone secretagogue receptor gene

General and Comparative Endocrinology, 2003
Synthetic growth hormone secretagogues stimulate growth hormone secretion by binding to a specific receptor, growth hormone secretagogue receptor (GHS-R). In this study, we investigated the cDNA and the genomic structure of chicken GHS-R. Chicken GHS-R gene is composed of two exons separated by an intron.
Yoshiyuki Ohta, Kiyoshi Shimada, Nobumichi Tsushima, Masaaki Wakita, Naoya Nakai, Ichiro Yamamoto, Takashi Miyazaki, Minoru Tanaka   +7 more
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Discovery and Pharmacological Evaluation of Growth Hormone Secretagogue Receptor Antagonists

Journal of Medicinal Chemistry, 2006
The discovery and pharmacological evaluation of potent, selective, and orally bioavailable growth hormone secretagogue receptor (GHS-R) antagonists are reported. Previously, 2,4-diaminopyrimidine-based GHS-R antagonists reported from our laboratories have been shown to be dihydrofolate reductase (DHFR) inhibitors.
Christi Kosogof, Thomas A. Fey, Brian A. Droz, Kathy Sarris, Zhili Xin, Christine A. Collins, Hongyu Zhao, Robin Shapiro, Teresa M. Turner, David W A Beno, Michael D. Serby, Victoria Knourek-Segel, Bruce G. Szczepankiewicz, Gang Liu, Hing L. Sham, Peer B. Jacobson, Charles W. Hutchins, Bo Liu, Mei Liu, Chun W. Lin, Michael E. Brune, Eugene N. Bush, Ethan D. Hoff, Christopher A. Ogiela, H. Douglas Falls   +24 more
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Distribution and regulation of chicken growth hormone secretagogue receptor isoforms

General and Comparative Endocrinology, 2003
Chicken ghrelin has recently been isolated as a hormone which stimulates growth hormone and corticosterone secretion in chicken. Ghrelin mediates these actions in mammals by binding to the growth hormone secretagogue receptor (GHS-R). In this study, we describe the partial cloning of two chicken GHS-R (cGHS-R) isoforms: cGHS-R1a and cGHS-R1c.
Veerle Darras, S. Van der Geyten, Sofie Geelissen, E.R. Kühn, I.M.E. Beck   +4 more
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Thyroid Hormones Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression

Journal of Neuroendocrinology, 2001
AbstractThyroid hormones regulate growth hormone (GH) secretion by actions both at the hypothalamus and at the pituitary gland. At the level of the pituitary, thyroid hormones increase GH and GH‐releasing hormone receptor (GHRH‐R) mRNA expression.
Jun Kamegai, Ichiji Wakabayashi, Hitoshi Sugihara, Hideki Tamura, Shinya Ishii   +4 more
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Glucocorticoids Regulate Pituitary Growth Hormone Secretagogue Receptor Gene Expression

Journal of Neuroendocrinology, 2000
AbstractGlucocorticoids regulate growth hormone (GH) secretion by modulating both hypothalamic and pituitary function. At the level of the pituitary, glucocorticoids increase GH and GH‐releasing hormone receptor (GHRH‐R) gene expression. To test if glucocorticoids might also regulate the pituitary expression of the recently identified GH secretagogue ...
Ichiji Wakabayashi, Rhonda D. Kineman, Lawrence A. Frohman, Hitoshi Sugihara, Hideki Tamura, Jun Kamegai   +5 more
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