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Ghrelin- and growth hormone secretagogue receptor-immunoreactive cells in Xenopus pancreas
Regulatory Peptides, 2011Ghrelin and its receptor, growth hormone secretagogue receptor (GHS-R), are produced by various cell types and affect feeding behavior, metabolic regulation, and energy balance. In the mammalian pancreas, the types of endocrine cells immunoreactive for ghrelin vary. Further, no study has clarified the type of endocrine cells producing ghrelin and GHS-R
Hirohumi Suzuki, Toshiharu Yamamoto
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Growth Hormone & IGF Research, 2000
Synthetic GH-releasing peptides such as GHRP-6 are potent GH secretagogues (GHSs) in several species, but attempts to stimulate growth by continuous GHS exposure have had limited success. GHSs also release ACTH and adrenal steroids. Since glucocorticoid excess is associated with poor linear growth, stimulation of the hypothalamo-pituitary-adrenal (HPA)
G. B. Thomas +3 more
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Synthetic GH-releasing peptides such as GHRP-6 are potent GH secretagogues (GHSs) in several species, but attempts to stimulate growth by continuous GHS exposure have had limited success. GHSs also release ACTH and adrenal steroids. Since glucocorticoid excess is associated with poor linear growth, stimulation of the hypothalamo-pituitary-adrenal (HPA)
G. B. Thomas +3 more
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Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
Trends in Endocrinology & Metabolism, 2001Growth hormone (GH) secretagogues (GHSs) are small synthetic molecules that act through a specific G-protein-coupled receptor (GPCR) called GHS-R. Until the recent identification of 'ghrelin' from rat and human stomachs, GHS-R was an orphan receptor (i.e. had no known natural ligand).
Hisayuki Matsuo +3 more
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The prospects of antagonizing the growth hormone secretagogue receptor to treat obesity
Expert Opinion on Therapeutic Patents, 2008Background: Ghrelin is an endogenous ligand of the growth hormone secretagogue receptor (GHS-R) that functions as a short-term meal initiator and a long-term energy balance regulator. Antagonizing GHS-R could be a method to treat obesity. Objective: To review the published in vivo characterization of GHS-R antagonists between 2005 and 2008 and evaluate
Bo Liu, Hongyu Zhao, Michael D. Serby
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Role of the Growth Hormone Secretagogue Receptor in the Central Nervous System
2002Aging is accompanied by a decline in the amplitude of the release of hormones, neurotransmitters and neuropeptides. These changes are associated with alterations in metabolism resulting in increases in deposition of visceral fat at the expense of muscle.
L. Betancourt, R. G. Smith, Yuxiang Sun
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Physiological Function of Growth Hormone Secretagogue Receptors in the Cardiovascular System
2003Growth hormone secretagogues (GHS) consist of a series of small enkephalin derived peptides identified as growth hormone-releasing peptides (GHRPs) (Bowers, 1993) and non-peptidyl derivatives modeled from GHRPs (Smith et al., 1997). To this class of compounds is recently added a new member, ghrelin, an endogenous 28 amino acid polypeptide isolated from
D. Lamontagne +3 more
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Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-vornhagen +2 more
exaly
GHSR: Growth Hormone Secretagogue Receptor
2016Yue Yin, Shiying Liu, Weizhen Zhang
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