Results 221 to 230 of about 60,269 (268)

The Growth Hormone Secretagogue Receptor

2007
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
openaire   +2 more sources

Growth Hormone–Releasing Hormone and Growth Hormone Secretagogue-Receptor Ligands

Endocrine, 2001
Growth hormone-releasing hormone (GHRH) and somatostatin are the most important hypothalamic neurohormones controlling growth hormone (GH) secretion. Several neurotransmitters and neuropeptides also play an important role in the control of GH secretion, mainly acting via modulation of GHRH and somatostatin. In the past two decades, particular attention
ARVAT, Emanuela, GIANOTTI L, GIORDANO, Roberta, BROGLIO, Fabio, MACCARIO, Mauro, LANFRANCO, Fabio, MUCCIOLI, Giampiero, PAPOTTI, Mauro Giulio, GRAZIANI A, GHIGO, Ezio, DEGHENGHI R.   +10 more
openaire   +5 more sources

Adenosine: A Partial Agonist of the Growth Hormone Secretagogue Receptor

Biochemical and Biophysical Research Communications, 2000
The growth hormone secretagogue receptor (GHS-R) is involved in the regulation of pulsatile GH release. However, until recently, natural endogenous ligands for the receptor were unknown. We fractionated porcine hypothalamic extracts and assayed fractions for activity on HEK293 cells expressing GHS-R and aequorin.
Yuan Xu, Andrew D. Howard, James M. Schaeffer, Anna Pomés, Alexander G.A. Smith, C.-S. Pong, Roy G. Smith, Roy G. Smith, Jimmy Calacay, Lex H.T. Van der Ploeg, Ken Liu, Reid J. Leonard, Patrick R. Griffin, Kang Cheng, Denis Leong, Scott D. Feighner   +15 more
openaire   +3 more sources

A relationship between motilin and growth hormone secretagogue receptors

Regulatory Peptides, 2012
The motilin receptor (MR) belongs to a family of Class I G protein-coupled receptors that also includes growth hormone secretagogue receptor (GHSR). Their potentially unique structure and the molecular basis of their binding and activation are not yet clear.
Morikazu Onji, Hiroaki Nunoi, Teruki Miyake, Bunzo Matsuura, Yoshiou Ikeda, Yoichi Hiasa, Shinya Furukawa, Teruhisa Ueda, Sachiko Utsunomiya, Teru Kumagi, Masanori Abe   +10 more
openaire   +3 more sources

Growth hormone secretagogue receptor antagonists

Expert Opinion on Therapeutic Patents, 2012
The patent claims peptidic/nonpeptidic inhibitors of the ghrelin receptor, the growth hormone secretagogue receptor (GHSR) 1A. Among these compounds, it was disclosed that the addition in some compounds of a GlyMetAla tripeptide at the N-terminus of the ghrelin peptide agonists converts them into ghrelin receptor antagonists.
openaire   +3 more sources

On the use of cells or membranes for receptor binding: Growth hormone secretagogues

Analytical Biochemistry, 2010
Receptor binding techniques have been widely used in different biochemical applications, with isolated membranes being the most used receptor preparation in this type of assays. In this study, intact cells were compared with isolated membranes as receptor support for radioligand receptor binding assay.
Zoran Nikolovski, Jordi Segura, Armand Pinyot, Ricardo Gutiérrez-Gallego, Jaume Bosch   +4 more
openaire   +3 more sources

Analysis of polymorphism of growth hormone secretagogue receptor in goat

Indian Journal of Animal Research, 2018
Two pairs of primers (GHSR-3, GHSR-4) were used to amplify GHSR gene of Boer goat, Yaoshan goat and black goat. Totally two mutation sites (SNP loci), G200A and T628C were detected in amplification fragments of GHSR-3 and GHSR-4 respectively. For locus G200A, allele frequencies of G and A in Yaoshan goat, Boer goat and black goat were 0.637/0.595/0.827
X. Wang, Shuai Yang, G. L. Li, Jun Yan Bai, You Bing Yang, Y. G. Zhao   +5 more
openaire   +2 more sources

Characterization of a Monoclonal Antibody Specific for the Growth Hormone Secretagogue Receptor

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2017
Ghrelin is an orexigenic peptide hormone that primarily regulates growth hormone secretion, food intake, and energy homeostasis. It has been shown to also play a role in numerous higher brain functions, such as the regulation of inflammation and cell proliferation. Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor (GHSR), a G-
K. Crotta, C. Casnici, N. Tonna, D. Lattuada, F. Bianco, O. Marelli   +5 more
openaire   +3 more sources

Molecular characterization of chicken growth hormone secretagogue receptor gene

General and Comparative Endocrinology, 2003
Synthetic growth hormone secretagogues stimulate growth hormone secretion by binding to a specific receptor, growth hormone secretagogue receptor (GHS-R). In this study, we investigated the cDNA and the genomic structure of chicken GHS-R. Chicken GHS-R gene is composed of two exons separated by an intron.
Yoshiyuki Ohta, Kiyoshi Shimada, Nobumichi Tsushima, Masaaki Wakita, Naoya Nakai, Ichiro Yamamoto, Takashi Miyazaki, Minoru Tanaka   +7 more
openaire   +3 more sources

Known and Unknown Growth Hormone Secretagogue Receptors and their Ligands

2004
The discovery of ghrelin is a typical example of reverse pharmacology: first the synthetic analogues (i.e. peptidyl and non-peptidyl growth hormone secretagogues (GHS)); second the receptor; third the natural ligand for this orphan receptor, i.e. ghrelin. Ghrelin is providing new understanding about how the gastrointestinal tract and nutritional intake
MUCCIOLI, Giampiero, BROGLIO, Fabio, Tarabra E., GHIGO, Ezio   +3 more
openaire   +3 more sources