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Effects of growth hormone secretagogues inside and outside the hypothalamichypophyseal system

open access: yes, 1998
Nilsson, M   +9 more
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Growth Hormone Secretagogues

Combinatorial Chemistry & High Throughput Screening, 2006
Growth hormone secretagogues (GHSs) are synthetic molecules that stimulate and amplify pulsatile pituitary growth hormone release, via a separate pathway distinct from GH releasing hormone/somatostatin. The activity of GHSs is not fully specific for GH secretion; some GHSs also have slight releasing activity on other pituitary hormones and mediate GH ...
Maria Luisa, Isidro, Fernando, Cordido
openaire   +4 more sources

Growth hormone secretagogues

Expert Opinion on Therapeutic Patents, 2000
Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
Johan Svensson
exaly   +2 more sources

A Nonpeptidyl Growth Hormone Secretagogue

Science, 1993
A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-{[2′-(1H-tetrazol-5-yl) (1,1′-biphenyl)-4-yl]methyl}-1H-1-benzazepin-3(R)-yl)-butanamide (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an ...
Roy G. Smith   +12 more
openaire   +2 more sources

New growth hormone secretagogues

Letters in Peptide Science, 2001
Starting from EP 51389, a potent growth hormone secretagogue (GHS), a new series of GHS has been designed, synthesized and tested. This series was built on a gem-diamino moiety and a structure activity relationship study was performed including N-methylation of the amide bonds.
Guerlavais, V   +5 more
openaire   +3 more sources

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