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Mention to Prof. Andrew V. Schally. [PDF]

Rev Endocr Metab Disord
Granata R.
europepmc   +1 more source

Growth Hormone-Releasing Peptides: Investigation of Their Secondary Structure, Thermal Stability, and Model Membrane Interactions. [PDF]

Chirality
Králík F, Kvíčalová A, Salaďáková A, Kuchař M, Setnička V.   +4 more
europepmc   +1 more source

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Highly potent growth hormone secretagogues

Bioorganic and Medicinal Chemistry Letters, 2007
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schleim, K. D.; Cheng, K.; Wei, L.; Chan, W.-S.; Butler, B.; Tsou, N.; Leung, K.; Chiu, S.-H.
Thomas M Jacks, Wanda W -S Chan, James R Tata   +2 more
exaly   +3 more sources

Growth hormone secretagogues

Expert Opinion on Therapeutic Patents, 2000
Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
Johan Svensson
exaly   +2 more sources

Growth hormone secretagogues: out of competition

Analytical and Bioanalytical Chemistry, 2011
Growth hormone secretagogues (GHS) constitute a new GH deficiency treatment increasing exponentially in number and improved potency and bioavailability over the last decade. The growth hormone releasing activity makes these compounds attractive for the artificial improvement of the human sports skills, now that recombinant human growth hormone (rhGH ...
Jordi Segura
exaly   +3 more sources

Growth Hormone-Releasing Hormone and Growth Hormone Secretagogues in Normal Aging

Endocrine, 2003
Growth hormone (GH) secretion declines with aging, and parallels between normal aging and the signs and symptoms of adult GH deficiency have led to interest in the potential utility of replacing or stimulating GH to promote physical and psychological function and to prolong the capacity for independent living in older adults.
Michael V Vitiello, George R Merriam
exaly   +3 more sources

Biologic Activities of Growth Hormone Secretagogues in Humans

Endocrine, 2001
Growth hormone secretagogues (GHSs) are synthetic peptidyl and nonpeptidyl molecules with strong, dose-dependent, and reproducible growth hormone (GH)-releasing activity even after oral administration. GHSs release GH via actions on specific receptors (GHS-R) at the pituitary and, mainly, at the hypothalamic levels.
GHIGO, Ezio, ARVAT, Emanuela, GIORDANO, Roberta, BROGLIO, Fabio, GIANOTTI L, MACCARIO, Mauro, BISI, Gianni, GRAZIANI A, PAPOTTI, Mauro Giulio, MUCCIOLI, Giampiero, DEGHENGHI R, CAMANNI, Franco   +11 more
openaire   +4 more sources

Glycine‐modified growth hormone secretagogues identified in seized doping material

Drug Testing and Analysis, 2019
A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis.
Kristian Linnet, Brian Schou Rasmussen, Niels Holm   +2 more
exaly   +2 more sources

Growth Hormone Secretagogues

Combinatorial Chemistry & High Throughput Screening, 2006
Growth hormone secretagogues (GHSs) are synthetic molecules that stimulate and amplify pulsatile pituitary growth hormone release, via a separate pathway distinct from GH releasing hormone/somatostatin. The activity of GHSs is not fully specific for GH secretion; some GHSs also have slight releasing activity on other pituitary hormones and mediate GH ...
Maria Luisa, Isidro, Fernando, Cordido
openaire   +4 more sources