Results 131 to 140 of about 6,358 (191)

Growth Hormone Secretagogues

Combinatorial Chemistry & High Throughput Screening, 2006
Growth hormone secretagogues (GHSs) are synthetic molecules that stimulate and amplify pulsatile pituitary growth hormone release, via a separate pathway distinct from GH releasing hormone/somatostatin. The activity of GHSs is not fully specific for GH secretion; some GHSs also have slight releasing activity on other pituitary hormones and mediate GH ...
Maria Luisa, Isidro, Fernando, Cordido
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New growth hormone secretagogues

Letters in Peptide Science, 2001
Starting from EP 51389, a potent growth hormone secretagogue (GHS), a new series of GHS has been designed, synthesized and tested. This series was built on a gem-diamino moiety and a structure activity relationship study was performed including N-methylation of the amide bonds.
Guerlavais, V, Boeglin, D, Fehrentz, JA, Deghenghi, R, LOCATELLI, VITTORIO, Martinez, J.   +5 more
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Tripeptide growth hormone secretagogues

Bioorganic & Medicinal Chemistry Letters, 1998
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide ...
L, Yang, G, Morriello, Y, Pan, R P, Nargund, K, Barakat, K, Prendergast, K, Cheng, W W, Chan, R G, Smith, A A, Patchett   +9 more
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Highly potent growth hormone secretagogues

Bioorganic & Medicinal Chemistry Letters, 2007
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schleim, K. D.; Cheng, K.; Wei, L.; Chan, W.-S.; Butler, B.; Tsou, N.; Leung, K.; Chiu, S.-H.
Zhijian, Lu, James R, Tata, Kang, Cheng, Liente, Wei, Wanda W-S, Chan, Bridget, Butler, Klaus D, Schleim, Thomas M, Jacks, Gerard, Hickey, Arthur A, Patchett   +9 more
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A Nonpeptidyl Growth Hormone Secretagogue

Science, 1993
A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-{[2′-(1H-tetrazol-5-yl) (1,1′-biphenyl)-4-yl]methyl}-1H-1-benzazepin-3(R)-yl)-butanamide (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an ...
Roy G. Smith, Kang Cheng, William R. Schoen, Sheng-Shung Pong, Gerard Hickey, Tom Jacks, Bridget Butler, Wanda W.-S. Chan, Lee-Yuh P. Chaung, Fred Judith, Joyce Taylor, Matthew J. Wyvratt, Michael H. Fisher   +12 more
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The Growth Hormone Secretagogue Receptor

2007
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
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Growth hormone secretagogues

Expert Opinion on Therapeutic Patents, 2000
Growth hormone secretagogues (GHSs) are synthetically produced peptides and non-peptides that stimulate growth hormone (GH) release by acting on one or more specific receptors. Treatment with GH itself is established in GH deficient children and adults and may also be useful in frail, elderly adults, in abdominally/viscerally obese subjects, in ...
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Growth Hormone Secretagogues: The Clinical Future

Hormone Research in Paediatrics, 1999
Growth hormone (GH) releasing hexapeptide (GHRP)-6 and other peptidergic and non-peptidergic compounds collectively designated GH secretagogues (GHS) are potent releasers of GH in man. Their clinical future may be envisioned in three areas: therapy of GH-deficient (GHD) states, diagnosis of GHD, and non-endocrinological actions.
D, Micic, X, Casabiell, O, Gualillo, M, Pombo, C, Dieguez, F F, Casanueva   +5 more
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Growth hormone secretagogues: out of competition

Analytical and Bioanalytical Chemistry, 2011
Growth hormone secretagogues (GHS) constitute a new GH deficiency treatment increasing exponentially in number and improved potency and bioavailability over the last decade. The growth hormone releasing activity makes these compounds attractive for the artificial improvement of the human sports skills, now that recombinant human growth hormone (rhGH ...
Pinyot, Armand, Nikolovski, Zoran, Bosch, Jaume, Such-Sanmartín, Gerard, Kageyama, Shinji, Segura, Jordi, Gutiérrez-Gallego, Ricardo   +6 more
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Growth Hormone Secretagogues and Hypothalamic Networks

Endocrine, 2001
Growth hormone secretagogues (GHSs) act at distinct levels to control growth hormone (GH) secretion. At the pituitary level they reinforce or extend a tonic GH-releasing-hormone (GHRH)-induced activated state by mobilizing intracellular Ca2+ store. At the hypothalamic level GHS actions are more complex than originally anticipated.
M T, Bluet-Pajot, V, Tolle, P, Zizzari, C, Robert, C, Hammond, V, Mitchell, J C, Beauvillain, C, Viollet, J, Epelbaum, C, Kordon   +9 more
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