Results 131 to 140 of about 5,558,251 (188)

Tripeptide growth hormone secretagogues

Bioorganic & Medicinal Chemistry Letters, 1998
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide ...
L, Yang, G, Morriello, Y, Pan, R P, Nargund, K, Barakat, K, Prendergast, K, Cheng, W W, Chan, R G, Smith, A A, Patchett   +9 more
openaire   +2 more sources

Highly potent growth hormone secretagogues

Bioorganic and Medicinal Chemistry Letters, 2007
During an effort to search for more potent growth hormone secretagogues, we discovered a class of compounds of which the best compound 8 was 7-fold more active in vitro than the best compound in the series we revealed before [Tata, J. R.; Lu, Z.; Jacks, T. M.; Schleim, K. D.; Cheng, K.; Wei, L.; Chan, W.-S.; Butler, B.; Tsou, N.; Leung, K.; Chiu, S.-H.
Thomas M Jacks, Bridget Butler, Wanda W -S Chan   +2 more
exaly   +3 more sources

The Growth Hormone Secretagogue Receptor

2007
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
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Growth hormone secretagogues in children with altered growth

Acta Paediatrica, 1997
A diagnostic test was devised to evaluate pituitary growth hormone (GH) secretory potential. GH secretory dynamics were assessed in children with and without GH deficiency. The GH response was measured to GH‐releasing hormone (GHRH) and the GH‐releasing peptide GHRP‐2, administered sequentially.
B B, Bercu, R F, Walker
openaire   +2 more sources

Growth Hormone Secretagogues: The Clinical Future

Hormone Research in Paediatrics, 1999
Growth hormone (GH) releasing hexapeptide (GHRP)-6 and other peptidergic and non-peptidergic compounds collectively designated GH secretagogues (GHS) are potent releasers of GH in man. Their clinical future may be envisioned in three areas: therapy of GH-deficient (GHD) states, diagnosis of GHD, and non-endocrinological actions.
D, Micic, X, Casabiell, O, Gualillo, M, Pombo, C, Dieguez, F F, Casanueva   +5 more
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Growth hormone secretagogues: out of competition

Analytical and Bioanalytical Chemistry, 2011
Growth hormone secretagogues (GHS) constitute a new GH deficiency treatment increasing exponentially in number and improved potency and bioavailability over the last decade. The growth hormone releasing activity makes these compounds attractive for the artificial improvement of the human sports skills, now that recombinant human growth hormone (rhGH ...
Pinyot, Armand, Nikolovski, Zoran, Bosch, Jaume, Such-Sanmartín, Gerard, Kageyama, Shinji, Segura, Jordi, Gutiérrez-Gallego, Ricardo   +6 more
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Growth Hormone Secretagogues and Hypothalamic Networks

Endocrine, 2001
Growth hormone secretagogues (GHSs) act at distinct levels to control growth hormone (GH) secretion. At the pituitary level they reinforce or extend a tonic GH-releasing-hormone (GHRH)-induced activated state by mobilizing intracellular Ca2+ store. At the hypothalamic level GHS actions are more complex than originally anticipated.
M T, Bluet-Pajot, V, Tolle, P, Zizzari, C, Robert, C, Hammond, V, Mitchell, J C, Beauvillain, C, Viollet, J, Epelbaum, C, Kordon   +9 more
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Growth Hormone and Growth Hormone Secretagogues in Adults

1999
The association of growth hormone (GH) with the promotion of linear growth in childhood has focused attention away from its role in adults, but GH secretion continues throughout life, reaching a maximum in adolescence and then declining progressively with age.
George R. Merriam, David E. Cummings
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Growth Hormone Secretagogues

Drugs, 1995
In recent years, several biosynthetic hexa- and heptapeptides, as well as nonpeptide bezolactam derivatives, have been found to be potent growth hormone (GH) secretagogues. They act synergistically with GH-releasing hormone (GHRH) but via different receptors, and are GHRH dependent.
openaire   +2 more sources

Interactions of Growth Hormone Secretagogues and Growth Hormone-Releasing Hormone/Somatostatin

Endocrine, 2001
The class of novel synthetic compounds termed growth hormone secretagogues (GHSs) act in the hypothalamus through, as yet, unknown pathways. We performed physiologic and histochemical studies to further understand how the GHS system interacts with the well-established somatostatin (SRIF)/growth hormone-releasing hormone (GHRH) neuroendocrine system for
G S, Tannenbaum, C Y, Bowers
openaire   +2 more sources