Results 131 to 140 of about 5,265,812 (178)

A Nonpeptidyl Growth Hormone Secretagogue

Science, 1993
A nonpeptidyl secretagogue for growth hormone of the structure 3-amino-3-methyl-N-(2,3,4,5-tetrahydro-2-oxo-1-{[2′-(1H-tetrazol-5-yl) (1,1′-biphenyl)-4-yl]methyl}-1H-1-benzazepin-3(R)-yl)-butanamide (L-692,429) has been identified. L-692,429 synergizes with the natural growth hormone secretagogue growth hormone-releasing hormone and acts through an ...
Roy G. Smith, Kang Cheng, William R. Schoen, Sheng-Shung Pong, Gerard Hickey, Tom Jacks, Bridget Butler, Wanda W.-S. Chan, Lee-Yuh P. Chaung, Fred Judith, Joyce Taylor, Matthew J. Wyvratt, Michael H. Fisher   +12 more
openaire   +2 more sources

New growth hormone secretagogues

Letters in Peptide Science, 2001
Starting from EP 51389, a potent growth hormone secretagogue (GHS), a new series of GHS has been designed, synthesized and tested. This series was built on a gem-diamino moiety and a structure activity relationship study was performed including N-methylation of the amide bonds.
Guerlavais, V, Boeglin, D, Fehrentz, JA, Deghenghi, R, LOCATELLI, VITTORIO, Martinez, J.   +5 more
openaire   +3 more sources

Tripeptide growth hormone secretagogues

Bioorganic & Medicinal Chemistry Letters, 1998
A series of C-terminus capped dipeptides and tripeptides was synthesized as growth hormone (GH) secretagogues. Among them, tripeptide Aib-D-Trp-D-homoPhe-OEt showed low nanomolar activity in the rat pituitary assay. Thus, we have demonstrated that the GH secretagogue activity of the hexa-hepta-GH releasing peptides can be mimicked at the tripeptide ...
L, Yang, G, Morriello, Y, Pan, R P, Nargund, K, Barakat, K, Prendergast, K, Cheng, W W, Chan, R G, Smith, A A, Patchett   +9 more
openaire   +2 more sources

The Effect of Growth Hormone Secretagogues and Neuropeptide Y on Hypothalamic Hormone Release from Acute Rat Hypothalamic Explants

Journal of Neuroendocrinology, 1999
Growth hormone (GH) secretagogues (GH-releasing peptides and their non-peptide analogues) stimulate growth hormone release via specific G-protein coupled receptors both directly from the pituitary gland and through stimulation of the hypothalamus.
Alfredo Costa, Marta Korbonits, Peter Trainer   +2 more
exaly   +2 more sources

The Growth Hormone Secretagogue Receptor

2007
The neuroendocrine hormone ghrelin, a recently discovered acylated peptide with numerous activities in various organ systems, exerts most of its known effects on the body through a highly conserved G-protein-coupled receptor, the growth hormone secretagogue receptor (GHSR) type 1a.
Conrad Russell Young, Cruz, Roy G, Smith
openaire   +2 more sources

Growth hormone secretagogues in children with altered growth

Acta Paediatrica, 1997
A diagnostic test was devised to evaluate pituitary growth hormone (GH) secretory potential. GH secretory dynamics were assessed in children with and without GH deficiency. The GH response was measured to GH‐releasing hormone (GHRH) and the GH‐releasing peptide GHRP‐2, administered sequentially.
B B, Bercu, R F, Walker
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Growth Hormone Secretagogues: The Clinical Future

Hormone Research in Paediatrics, 1999
Growth hormone (GH) releasing hexapeptide (GHRP)-6 and other peptidergic and non-peptidergic compounds collectively designated GH secretagogues (GHS) are potent releasers of GH in man. Their clinical future may be envisioned in three areas: therapy of GH-deficient (GHD) states, diagnosis of GHD, and non-endocrinological actions.
D, Micic, X, Casabiell, O, Gualillo, M, Pombo, C, Dieguez, F F, Casanueva   +5 more
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Growth Hormone Secretagogues and Hypothalamic Networks

Endocrine, 2001
Growth hormone secretagogues (GHSs) act at distinct levels to control growth hormone (GH) secretion. At the pituitary level they reinforce or extend a tonic GH-releasing-hormone (GHRH)-induced activated state by mobilizing intracellular Ca2+ store. At the hypothalamic level GHS actions are more complex than originally anticipated.
M T, Bluet-Pajot, V, Tolle, P, Zizzari, C, Robert, C, Hammond, V, Mitchell, J C, Beauvillain, C, Viollet, J, Epelbaum, C, Kordon   +9 more
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Growth Hormone and Growth Hormone Secretagogues in Adults

1999
The association of growth hormone (GH) with the promotion of linear growth in childhood has focused attention away from its role in adults, but GH secretion continues throughout life, reaching a maximum in adolescence and then declining progressively with age.
George R. Merriam, David E. Cummings
openaire   +1 more source

Growth Hormone Secretagogues

Drugs, 1995
In recent years, several biosynthetic hexa- and heptapeptides, as well as nonpeptide bezolactam derivatives, have been found to be potent growth hormone (GH) secretagogues. They act synergistically with GH-releasing hormone (GHRH) but via different receptors, and are GHRH dependent.
openaire   +2 more sources