Results 151 to 160 of about 6,358 (191)

Hypothalamic targets for growth hormone secretagogues

Acta Paediatrica, 1997
Various novel growth hormone (GH) secretagogues have been developed. GH secretagogues release GH directly from the pituitary via a pathway distinct from that involving GH‐releasing hormone (GHRH). However, they also act centrally to activate hypothalamic neurones, and require an intact GHRH system for potent in vivo activity. Both normal and transgenic
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Growth Hormone Secretagogues in Critical Illness

Hormone Research in Paediatrics, 1999
Alterations within the somatotropic axis occurring during the course of critical illness follow a biphasic pattern. The initial stress response consists of activated growth hormone (GH) release whereas circulating levels of GH-dependent insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-3 fall and IGFBP-1 concentrations rise.
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The Growth Hormone Secretagogue Receptor (Ghs-R)

Current Pharmaceutical Design, 2012
The growth hormone secretagogue receptor (GHS-R) is a component of the ghrelin signaling pathway and is involved in mediating the pleiotropic effects of ghrelin. Two isoforms have been identified, but only GHS-R1a binds with acyl ghrelin and transduces its message.
LAVIANO, Alessandro, MOLFINO, ALESSIO, Serena Rianda, ROSSI FANELLI, Filippo   +3 more
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Growth hormone secretagogues.

IDrugs : the investigational drugs journal, 2005
Growth hormone secretagogues (GHSs) are a class of synthetic compounds that increase growth hormone secretion and serum IGF-1 concentrations. The short-acting GHSs produce transient elevations in GH which lead to little or no changes in IGF-1; the long-acting GHSs stimulate pulsatile GH release due to sustained elevations of IGF-1.
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Nonpeptidyl Growth Hormone Secretagogues

1996
The availability of recombinant human growth hormone (rhGH) in the mid1980s has fostered a renewed interest in potential clinical applications of growth hormone (GH). In addition to the treatment of GH-deficient children and adults, rhGH may have beneficial effects in the treatment of patients with burns, bone fractures, or Turner’s syndrome, in ...
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Ipamorelin, the first selective growth hormone secretagogue

European Journal of Endocrinology, 1998
The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin is a pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency and efficacy in vitro and in vivo. As an outcome of a major chemistry programme, ipamorelin was identified within a series of compounds ...
K, Raun, B S, Hansen, N L, Johansen, H, Thøgersen, K, Madsen, M, Ankersen, P H, Andersen   +6 more
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Growth Hormone and Growth Hormone Secretagogues in Adults

1999
The association of growth hormone (GH) with the promotion of linear growth in childhood has focused attention away from its role in adults, but GH secretion continues throughout life, reaching a maximum in adolescence and then declining progressively with age.
George R. Merriam, David E. Cummings
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Chapter 22. Growth Hormone Secretagogues

1997
Publisher Summary In recent times, highly active growth hormone releasing peptides (GHRPs) and GHRP peptidomimetics, with short-acting and long-acting pharmacodynamic profiles, has received considerable attention as potential alternatives to injectable growth hormone (GH) replacement therapy.
Ravi P. Nargund, Lex H.T. Van der Ploeg
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Chapter 19. Growth Hormone Secretagogues

1993
Publisher Summary With the evolution of modern recombinant DNA technology, human growth hormone has become more widely available. While secretion of pituitary hormones is a complex process that is influenced by a variety of factors, both hormonal and behavioral, the principal regulator is a corresponding hypothalamic releasing factor or secretagogue.
William R. Schoen, Matthew J. Wyvratt, Roy G. Smith   +2 more
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Xenobiotic Growth Hormone Secretagogues: Growth Hormone Releasing Peptides

1996
A number of different and still evolving concepts, strategies, approaches, and techniques underlie the story of the growth hormone releasing peptides (GHRPs). Even though the origin of the GHRPs was artificial, many investigators have validated these peptides as distinct chemical entities with novel actions on growth hormone (GH) release in animals and
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