Results 121 to 130 of about 12,563,372 (298)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Influence of insulin on growth hormone secretion, level and growth hormone signalling

, 2017
Growth hormone (GH), as a vital hormone, has to experience a series of processes to fulfill its function including secretion, entering the circulation to reach target tissues (pre-receptor process), binding on the GH receptor (GHR) and triggering ...
Qiu, H, Chen, C, Yang, JK
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Cost-effectiveness of a connected injection device for daily somatropin therapy in pediatric growth hormone deficiency in Spain: a scenario-based microsimulation analysis using real-world data

Journal of Comparative Effectiveness Research
Aim: Growth hormone deficiency (GHD) in pediatric patients is characterized by impaired growth and reduced quality of life. Recombinant human growth hormone therapy requires consistent daily administration, yet adherence remains challenging. Electronic
Antonio de Arriba, Claudia Roeder, Emilia Nivelle, Paula van Dommelen, Jose J Alcon Saez, Cristina Latre Gorbe, Heidi de los Santos Real, Irene Sánchez-Collado, Falko Boehm, Cristina Masseria   +9 more
doaj   +1 more source

Recombinant growth hormone for children with systemic lupus erythematosus and linear growth delay: A report of two cases and literature review

Journal of International Medical Research
Linear growth delay is common in children with systemic lupus erythematosus. There have been scattered reports of using recombinant human growth hormone in these children, but safety remains a major concern.
Fujuan Liu, Xiaoying Yuan, Yanjun Yang, Yanan Han, Lanlan Ge, Jingxiao Guo, Ling Liu, Chunzhen Li, Dongfeng Zhang   +8 more
doaj   +1 more source

Treatment with long-acting growth hormone: effectiveness and safety

Frontiers in Endocrinology
Long-acting growth hormone (GH) formulations represent a clinically effective alternative to daily recombinant human GH (rhGH) administration, enabling extended dosing intervals and enhancing patient adherence. This approach is particularly beneficial in
Livia Basile, Rossella Cannarella, Rosita A. Condorelli, Francesco Frasca, Aldo E. Calogero, Sandro La Vignera   +5 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Personalized Approach to Growth Hormone Treatment: Clinical Use of Growth Prediction Models

, 2013
The goal of growth hormone (GH) treatment in a short child is to attain a fast catch-up growth toward the target height (TH) standard deviation score (SDS), followed by a maintenance phase, a proper pubertal height gain, and an adult height close to TH ...
Jung, H, Ranke, M, Buuren, S. van, Ranke, M B, Hokken-Koelega, A C S, CIANFARANI, STEFANO, Hokken-Koelega, A C S,, Audi, L, Hokken-Koelega, A, Bang, P., Clayton, P. E.; id_orcid, Bang, P, Graaff, L. de, Silverman, L.A., Rosenfeld, R G, Wit, J, Clayton, P.E., Hokken Koelega, A, Schoenau, E, Blum, WF, Van Buuren, S, Albertsson Wikland, K, Cianfarani, S, Albertsson-Wikland, Kerstin,, Kleintjens, J, Albertsson-Wikland, K, Ranke, MB, Deal, C, Carrascosa, A, Hokken-Koelega, A.C.S., Silverman, L A, Van Buuren, S,, Cohen, P., Cohen, P,, Hokken - Koelega, Anita, Hokken-Koelega, A. C. S., Wit, J. M., Ranke, M. B., Rosenfeld, R.G., Deal, C,, Silverman, L. A., Jung, H,, Deal, C., Jung, H., Albertsson-Wikland, K,, Albertsson-Wikland, K., Roelants, M, Ranke, M B.,, Clayton, PE, Clayton, P, Blum, W F.,, Wit, JM, Kriström, Berit,, Clayton, P E.,, Kristrom, B., Wit, J M.,, Roelants, M,, Kleintjens, J,, Cianfarani, S., Roelants, M., Kleintjens, J., Kristrom, B,, Cianfarani, S,, Blum, W.F., Hokken-Koelega, A. C S, Wit, J.M., de Graaff, L, Dahlgren, Jovanna,, Clayton, P. E., Clayton, P E, de Graaff, L,, Bang, Peter,, Audi, L., Dahlgren, J, Schoenau, E., Cohen, P, Audi, L,, Rosenfeld, R, A Silverman, L,, Ranke, M.B., Schoenau, E,, Silverman, LA, Rosenfeld, R G.,, Blum, W. F., Blum, W F, Wit, J M, Blum, W, Dahlgren, J., Dahlgren, J,, Carrascosa, A., Carrascosa, A,, Rosenfeld, RG, Kristrom, B, Rosenfeld, R. G., Silverman, L, De Graaff, L., Van Buuren, S., Van, Buuren S, Hokken-Koelega, ACS   +98 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source