Results 101 to 110 of about 12,563,372 (298)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

From growth hormone deficiency to Kleefstra-2 syndrome: diagnostic  reassessment of treatment-refractory short stature

We report a 12-year-old girl with developmental delay, dysmorphic features, and short stature initially diagnosed with growth hormone deficiency at age 7.
Rachid Abilkassem, Abdelilah Radi, Azzeddine Laaraje, Khadija Abassi, Radi, Abdelilah, Abassi, Khadija Belcadi, Abilkassem, Rachid, Laaraje, Azzeddine   +7 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Peripheral growth hormone induces cell proliferation in the intact adult rat brain

, 2010
Growth hormone (GH) and insulin-like growth factor I (IGF-I) increase cell genesis in several regions of the brains of GH-IGF-I-deficient hypophysectomized rats.
Lind, Johan,, Kuhn, Hans-Georg,, Åberg, N David,, Isgaard, Jörgen,   +3 more
core  

Early cessation and non-response are important and possibly related problems in growth hormone therapy: An OZGROW analysis

, 2016
Objective: To investigate growth hormone (GH) treatment and treatment cessation with respect to efficacy and efficiency. To identify factors that best classify or predict cessation type: completed treatment (CT), early cessation (EC), or non-response (NR)
Harris, M., Cutfield, W., Cotterill, A, Hughes, IP, Hughes, I., Harris, M, Rath, S, Choong, C., Cotterill, A., Rath, S., Choong, C, Atkinson, Helen, Hofman, P., Atkinson, H, Cutfield, W, Hofman, P   +15 more
core   +1 more source

Growth Charts for Prader-Willi Syndrome During Growth Hormone Treatment. [PDF]

, 2016
The purpose of the current study was to develop syndrome-specific standardized growth curves for growth hormone-treated Prader-Willi syndrome (PWS) individuals aged 0 to 18 years.
Dykens, Elisabeth, Driscoll, Daniel J, Manzardo, Ann M, Roof, Elizabeth, Butler, Merlin G, Gold, June-Anne, Lee, Jaehoon, Cox, Devin M, Kimonis, Virginia, Miller, Jennifer L   +9 more
core   +1 more source

Corrigendum: Usefulness and Potential Pitfalls of Long-Acting Growth Hormone Analogues

Frontiers in Endocrinology, 2021
Kevin C. J. Yuen, Bradley S. Miller, Cesar L. Boguszewski, Andrew R. Hoffman   +3 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Impact of growth hormone preparation switching on treatment outcomes in children with growth hormone deficiency: a retrospective real-world cohort study

BMC Endocrine Disorders
Background Switching between recombinant human growth hormone (rhGH) preparations has become increasingly common in pediatric practice because of reimbursement policies, product availability, and patient preferences.
Duygu Deligozoglu, Irem Gokdemir, Can Alp Genc, Gonul Buyukyilmaz, Sirmen Kizilcan Cetin, Emregul Işik, Hande Nur Sengil, Derya Tepe, Pinar Kocaay, Mehmet Boyraz, Fatih Gurbuz   +10 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source