Results 81 to 90 of about 451,544 (302)

Analysis of Craniofacial and Extremity Growth in Patients with Growth Hormone Deficiency during Growth Hormone Therapy [PDF]

, 2009
Background/Aims: There are many controversies regarding side effects on craniofacial and extremity growth due to growth hormone ( GH) treatment. Our aim was to estimate GH action on craniofacial development and extremity growth in GH-deficient patients ...
ARNHOLD, Ivo Jorge Prado, ROSSETTO, Shirley M., BERGER, Karina, AMARAL, Terezinha Sampaio, MENDONCA, Berenice Bilharinho, FARIA, Maria Estela Justamante de, CARVALHO, Luciani R.   +6 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma. [PDF]

, 2013
Includes abstract.Includes bibliographical references.Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low.
Boris Krivochiev, Krivochiev, Boris
core  

From growth hormone deficiency to Kleefstra-2 syndrome: diagnostic  reassessment of treatment-refractory short stature [PDF]

We report a 12-year-old girl with developmental delay, dysmorphic features, and short stature initially diagnosed with growth hormone deficiency at age 7.
Rachid Abilkassem, Abdelilah Radi, Azzeddine Laaraje, Khadija Abassi   +3 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Influence of insulin on growth hormone secretion, level and growth hormone signalling [PDF]

, 2017
Growth hormone (GH), as a vital hormone, has to experience a series of processes to fulfill its function including secretion, entering the circulation to reach target tissues (pre-receptor process), binding on the GH receptor (GHR) and triggering ...
Qiu, H, Chen, C, Yang, JK
core   +1 more source

Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults

Journal of Endocrinological Investigation, 2008
The V Consensus Group Meeting on 'Guidelines for Treatment of GH Excess and GH Deficiency in the Adult' was an international workshop held on February 20-22, 2006 in Santa Monica, California, USA. The principal aim of this meeting was to provide guidelines for the evaluation and treatment of adults with either form of abnormal GH secretion: GH excess ...
GIUSTINA, Andrea, Barkan A, Chanson P, Grossman A, Hoffman A, Ghigo E, Casanueva F, Colao A, Lamberts S, Sheppard M, Melmed S, Pituitary Society, European Neuroendocrine Association   +12 more
openaire   +9 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Peripheral growth hormone induces cell proliferation in the intact adult rat brain [PDF]

, 2010
Growth hormone (GH) and insulin-like growth factor I (IGF-I) increase cell genesis in several regions of the brains of GH-IGF-I-deficient hypophysectomized rats.
Lind, Johan,, Kuhn, Hans-Georg,, Åberg, N David,, Isgaard, Jörgen,   +3 more
core  

Growth hormone attenuates skeletal muscle changes in experimental chronic heart failure [PDF]

, 2010
Objective: This study evaluated the effects of growth hormone (GH) on morphology and myogenic regulatory factors (MRF) gene expression in skeletal muscle of rats with ascending aortic stenosis (AAS) induced chronic heart failure.Design: Male 90-100 g ...
dos Santos, Denis Pioli, Padovani, Carlos Roberto, Okoshi, Katashi [UNESP], Alves de Almeida, Fernanda Losi, Seiva, Fabio R. F. [UNESP], Moreira, Vanessa O., Padovani, Carlos Roberto [UNESP], dos Santos, Denis Pioli [UNESP], Cicogna, Antonio Carlos [UNESP], Okoshi, Marina Politi, Alves de Almeida, Fernanda Losi [UNESP], Barros Castro, Ana Valeria, Moreira, Vanessa O. [UNESP], Dal Pai-Silva, Maeli [UNESP], Barros Castro, Ana Valeria [UNESP], Carvalho, Robson Francisco [UNESP], Okoshi, Katashi, Okoshi, Marina Politi [UNESP], Carvalho, Robson Francisco, Cicogna, Antonio Carlos, Dal Pai-Silva, Maeli, Seiva, Fabio R. F.   +21 more
core   +1 more source