Results 91 to 100 of about 11,873,006 (292)

Immunofunctional assay of human growth hormone (hGH) in serum: A possible consensus for quantitative hGH measurement [PDF]

, 1996
Confirmation of the diagnosis of GH deficiency in adults and children involves provocative testing for human (h) GH. Different commercially available immunoassays yield largely discrepant results in the measurement of GH levels in human serum.
Strasburger, Christian J., Pflaum, Claus-Dieter, Dressendörfer, Regina A., Wu, Zida   +3 more
core   +1 more source

The effect of growth hormone treatment on head circumference in growth hormone-deficient children

The Turkish Journal of Pediatrics, 2008
The aim of this study was to analyze head circumference (HC) growth retrospectively in longitudinally followed growth hormone (GH)-deficient children on GH therapy.
Feyza Darendeliler, Firdevs Baş, Müge Gökçe, Sükran Poyrazoğlu, Mine Sükür, Rüveyde Bundak, Nurçin Saka, Hülya Günöz   +7 more
doaj  

Effects of Growth Hormone Replacement Therapy on Bone Mineral Density in Growth Hormone Deficient Adults: A Meta-Analysis

International Journal of Endocrinology, 2013
Objectives. Growth hormone deficiency patients exhibited reduced bone mineral density compared with healthy controls, but previous researches demonstrated uncertainty about the effect of growth hormone replacement therapy on bone in growth hormone ...
Peng Xue, Yan Wang, Jie Yang, Yukun Li
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Pharmocogenetic study on efficacy of recombinant growth hormone treatment in short stature patients with growth hormone deficiency

, 2009
[[abstract]]Growth hormone (GH) is the most important one to stimulate human body growth and it is especially significant for children before puberty.
Wei-Cheng Chen
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Cost-consequence analysis for human recombinant growth hormone (r-hGH) treatment administered via different devices in children with growth hormone deficiency in Italy

ClinicoEconomics and Outcomes Research, 2019
Jason Foo,1 Mohamad Maghnie,2 Annamaria Colao,3 Ioanna Vlachaki,4 Giorgio Colombo5,61Global Health Economics, Mapi Group (An ICON plc Company), Houten, The Netherlands; 2Department of Pediatrics, IRCCS Istituto Giannina Gaslini Institute, University of ...
Foo J, Maghnie M, Colao A, Vlachaki I, Colombo G   +4 more
doaj  

The effect of growth hormone treatment on serum bone alkaline phosphatase in growth hormone deficient children [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2008
Introduction: Growth hormone (GH) promotes longitudinal growth in children with growth hormone deficiency. Serum bone alkaline phosphatase (BALP) has been considered to be a good marker of bone formation with narrow circadian variation.
Maria Korpal-Szczyrska, Anna Balcerska
doaj  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source