Results 101 to 110 of about 870,777 (309)

Regulators of growth plate maturation

, 2010
Estrogen is known to play an important role in longitudinal bone growth and growth plate maturation, but the mechanism by which estrogens exert their effect is not fully understood. In this thesis this role is further explored.
Emons, J.A.M.
core  

Growth cartilage expression of growth hormone/insulin-like growth factor I axis in spontaneous and growth hormone induced catch-up growth [PDF]

, 2012
Introduction: Catch-up growth following the cessation of a growth inhibiting cause occurs in humans and animals. Although its underlying regulatory mechanisms are not well understood, current hypothesis confer an increasing importance to local factors ...
Santos Rodríguez, Fernando, Caldas-Afonso, A, Loredo, V, Caldas-Afonso, Alberto, Santos, F, Tiago Henriques-Coelho, Coelho, Tiago Alexandre Henriques, Brito, Iva, Gil-Peña, H, Loredo López, Vanessa, Molinos, I, Gil Peña, Helena, Brito, I, Molinos Norniella, Inés   +13 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Transcriptome analysis reveals the pathogenesis of spontaneous tibial dyschondroplasia in broilers

Frontiers in Genetics
Tibial dyschondroplasia (TD) is a severe bone disease that affects fast-growing broiler chickens and causes economic loss. Despite previous studies, the regulatory mechanism of TD remains unclear and is thought to be primarily based on thiram induction ...
Kai Shi, Kai Shi, Yongfu Wu, Xusheng Jiang, Xiangping Liu, Yuesong Du, Chungang Feng, Dongfeng Li   +7 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Injury responses and repair mechanisms of the injured growth plate

, 2011
The growth plate is responsible for longitudinal growth of children's long bones. However, being a cartilaginous tissue, the growth plate has a limited ability for regeneration and thus injured growth plate is often repaired by bony tissue resulting in ...
Xian, C., Chung, R., Foster, B.
core   +1 more source

The kinetics of primary alpha plate growth in titanium alloys [PDF]

, 2019
The kinetics of primary alpha-Ti colony/Widmanstatten plate growth from the beta are examined, comparing model to experiment. The plate growth velocity depends sensitively both on the diffusivity D(T) of the rate-limiting species and on the ...
Bagot, Paul AJ, Radecka, Anna, Michael P. Moody, Knowles, Alexander J, Moody, Michael P, Ioannis Bantounas, André A. N. Németh, Reed, Roger C., Ackerman, Abigail, Alexander J. Knowles, Paul A. J. Bagot, Rugg, David R, Bagot, Paul A. J., Nemeth, Andre AN, Ackerman, Abigail K., David Dye, Gardener, Hazel M, Dye, David, Ackerman, Abigail K, Roger C. Reed, Knowles, Alexander J., Bantounas, Ioannis, Németh, André A. N., Bagot, Paul A.J., Knowles, Alexander, Németh, André A.N., Rugg, David, Reed, Roger C, Gardner, Hazel M, David Rugg, Moody, Michael P., Abigail K. Ackerman, Hazel M. Gardner, Anna Radecka, Gardner, Hazel M.   +34 more
core   +1 more source

Effects of in ovo administrated aflatoxin b1 on the embryonic development of proximal tibial growth plate in broiler chickens [PDF]

Eurasian Journal of Veterinary Sciences
In this study, detrimental effects of in ovo given aflatoxin B, (AFB,) on the embryonic development of tibia and its proximal growth plate were determined by means of histologic and histometric methods.
Yasemin Öznurlu, İlhami Çelik
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A novel link between chronic inflammation and humanin regulation in children

Frontiers in Endocrinology
ObjectiveChildren with inflammatory bowel disease (IBD) often suffer from poor bone growth and impaired bone health. Humanin is a cytoprotective factor expressed in bone and other tissues and we hypothesized that humanin levels are suppressed in ...
Yunhan Zhao, Outi Mäkitie, Outi Mäkitie, Saila Laakso, Vera Fedosova, Lars Sävendahl, Farasat Zaman   +6 more
doaj   +1 more source