Results 131 to 140 of about 1,812,103 (301)

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

The Seasonal Incidence of Slipped Capital Femoral Epiphysis: A Systematic Review and Meta-Analysis

Children
Background/Objectives: Slipped capital femoral epiphysis (SCFE) is a common adolescent hip disorder characterized by the posterior and inferior slippage of the femoral head through the growth plate.
Carter J. K. White, Jacob D. Kodra, Harshavardhan Bollepalli, Kai Yang, Scott E. Van Valin, Xue-Cheng Liu   +5 more
doaj   +1 more source

Room temperature crack growth rates and -20 deg F fracture toughness of welded 1 1/4 inch A-285 steel plate [PDF]

Data are presented which were developed in support of a structural assessment of NASA-LEWIS' 10-foot by 10-foot supersonic wind tunnel, critical portions of which are fabricated from rolled and welded 1 1/4 inch thick A-285 steel plate. Test material was
Rzasnicki, W., Shannon, J. L., Jr.
core   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Evaluation of the effect of osteosynthesis wires on the structural reorganization of metaepiphyseal cartilage (an experimental and morphological study)

Гений oртопедии
Introduction Premature arrest of bone growth is the most common complication of bone fractures at the growth plate level. The purpose of the work was to evaluate the structural reorganization of metaepiphyseal cartilage following its direct injury ...
Anatoly A. Korobeinikov, Tatyana A. Stupina, Olga V. Dyuryagina, Mikhail A. Stepanov, Nikolai I. Antonov   +4 more
doaj   +1 more source

Monogenic causes of familial short stature

Frontiers in Endocrinology
Genetic factors play a crucial role in determining human height. Short stature commonly affects multiple family members and therefore, familial short stature (FSS) represents a significant proportion of growth disorders. Traditionally, FSS was considered
Lukas Plachy, Petra Dusatkova, Shenali Anne Amaratunga, Vit Neuman, Zdenek Sumnik, Jan Lebl, Stepanka Pruhova   +6 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Leading-edge receptivity to a vortical freestream disturbance: A numerical analysis [PDF]

The receptivity to freestream vorticity of the boundary layer over a flat plate with an elliptic leading edge is investigated numerically. The flow is simulated by solving the incompressible Navier-Stokes system in general curvilinear coordinates with ...
Buter, Thomas A., Reed, Helen L.
core   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Design of anisotropic plates for improved damage tolerance [PDF]

An analytical study is presented showing the effects of the notch tip geometry on the location and direction of crack growth from an existing notch in a unidirectional fibrous composite modeled as a homogeneous, anisotropic, elastic material. Anisotropic
Guerdal, Zafer
core   +1 more source