Results 151 to 160 of about 1,817,169 (352)

Evaluation of the effect of osteosynthesis wires on the structural reorganization of metaepiphyseal cartilage (an experimental and morphological study)

Гений oртопедии
Introduction Premature arrest of bone growth is the most common complication of bone fractures at the growth plate level. The purpose of the work was to evaluate the structural reorganization of metaepiphyseal cartilage following its direct injury ...
Anatoly A. Korobeinikov, Tatyana A. Stupina, Olga V. Dyuryagina, Mikhail A. Stepanov, Nikolai I. Antonov   +4 more
doaj   +1 more source

Monogenic causes of familial short stature

Frontiers in Endocrinology
Genetic factors play a crucial role in determining human height. Short stature commonly affects multiple family members and therefore, familial short stature (FSS) represents a significant proportion of growth disorders. Traditionally, FSS was considered
Lukas Plachy, Petra Dusatkova, Shenali Anne Amaratunga, Vit Neuman, Zdenek Sumnik, Jan Lebl, Stepanka Pruhova   +6 more
doaj   +1 more source

Room temperature crack growth rates and -20 deg F fracture toughness of welded 1 1/4 inch A-285 steel plate [PDF]

Data are presented which were developed in support of a structural assessment of NASA-LEWIS' 10-foot by 10-foot supersonic wind tunnel, critical portions of which are fabricated from rolled and welded 1 1/4 inch thick A-285 steel plate. Test material was
Rzasnicki, W., Shannon, J. L., Jr.
core   +1 more source

Effect of rolling ratio on static tensile properties, charpy impact energy and fatigue crack growth behavior of a thick rolled steel plate.

, 1984
Shoji Harada, Tatsuo Endo, Yasunobu Sakamoto, Hiroshi Hamamatsu   +3 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Cortical bone development under the growth plate is regulated by mechanical load transfer [PDF]

, 2006
Esther Tanck, Gerjon Hannink, R Ronald Ruimerman, Pieter Buma, Elisabeth H. Burger, R. Huiskes   +5 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

"Growth plate fracture of the proximal tibia in a young adult with an unfused growth plate: A case report". [PDF]

Int J Surg Case Rep, 2023
Jadib I, Lamris MA, Tabbak K, Messoudi A, Rafai M.   +4 more
europepmc   +1 more source

Leading-edge receptivity to a vortical freestream disturbance: A numerical analysis [PDF]

The receptivity to freestream vorticity of the boundary layer over a flat plate with an elliptic leading edge is investigated numerically. The flow is simulated by solving the incompressible Navier-Stokes system in general curvilinear coordinates with ...
Buter, Thomas A., Reed, Helen L.
core   +1 more source