Results 221 to 230 of about 6,248 (265)

Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway

Journal for ImmunoTherapy of Cancer
Background Clofarabine (Clo) is a Food and Drug Administration (FDA)-approved drug for the treatment of acute lymphoblastic leukemia; however, its effects on solid tumors remain largely unknown.
Jie Wu, Nian Liu, Jing Chen, Qian Tao, Can Lu, Qiuqiu Li, Xiang Chen, C. Peng   +7 more
semanticscholar   +1 more source

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway

Acta Pharmacologica Sinica, 2023
Proteasomes are overexpressed in multiple myeloma (MM) and proteasomal inhibitors (PIs) have been widely used for the treatment of MM. PIs are reported to induce MM cell apoptosis but impair necroptosis. In the present study, we found that PIs MG132 and bortezomib induce MM cell pyroptosis, a novel type of cell death, in a GSDME-dependent manner.
Jing-Pei, Liang, Yuan-Ming, He, Yao-Li, Cui, Yue-Ning, Sun, Gui-Song, He, Zhi-Gang, Zhu, Xin-Liang, Mao   +6 more
openaire   +2 more sources

Phosphorylated IRF3 promotes GSDME-mediated pyroptosis through RIPK1/FADD/caspase-8 complex formation during mitotic arrest in ovarian cancer

Cell Communication and Signaling
Inducing mitotic arrest with anti-mitotic drugs is an effective strategy for cancer therapy. However, the ultimate fate of cells that undergo prolonged mitotic arrest remains largely uncertain. In this study, paclitaxel and nocodazole were used to induce
Wenjian Gong, Dongchen Zhou, Qiuyang Xu, Linghui Wang, Mengshi Luo, Yuewen Zhang, Zhiqi Liao, Fan Xiong, Guangnian Zhao, Bingbing Zhao, Q. Gao, Yong Fang   +11 more
semanticscholar   +1 more source

GSDME Is Related to Prognosis and Response to Chemotherapy in Oral Cancer

Journal of Dental Research, 2022
Gasdermin E (GSDME), as the major executive protein of pyroptosis, has been considered to be linked to antitumor immunity in recent years. However, the role of GSDME in oral squamous cell carcinoma (OSCC) remains to be elucidated. Here, by using a human OSCC tissue microarray, human OSCC tissue, and Tgfbr1/ Pten conditional knockout mice, we found ...
S, Wang, M J, Zhang, Z Z, Wu, S W, Zhu, S C, Wan, B X, Zhang, Q C, Yang, Y, Xiao, L, Chen, Z J, Sun   +9 more
openaire   +2 more sources

Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis

Cell Death and Disease
Non-small cell lung cancer (NSCLC) is highly malignant with limited treatment options, largely due to the inherent tumoral heterogeneity and acquired resistance towards chemotherapy and immunotherapy.
Gaoyan Tang, Xuelei Cao, Jiaqi Chen, Fu Hui, Na Xu, Yiqing Jiang, Hongmin Lu, Haifeng Xiao, Xiuming Liang, Mingzhe Ma, Yu Qian, Dongli Liu, Zhenlu Wang, Shuzhen Liu, Guohua Yu, Lei Sun   +15 more
semanticscholar   +1 more source

Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis

Journal of Dermatological Science, 2021
Oncostatin M (OSM), an interleukin-6 (IL-6) family proinflammatory cytokine, plays a critical role in inflammatory skin diseases, but its mechanism of action is not well understood.To demonstrate the mechanism of OSM induced pyropotosis in normal human epidermal keratinocytes (NHEKs) and immortalized human keratinocytes (HaCaT cells).NHEKs and HaCaT ...
Jun, Liu, Yadan, Zhong, Huiting, Liu, Huan, Yang, Ping, Lu, Yanqiang, Shi, Xuan, Wang, Wen, Zheng, Xiaoling, Yu, Yingping, Xu, Bin, Yang   +10 more
openaire   +2 more sources

A new type of Caspase-1 upon recognizing bacteria inhibits GSDME-dependent histone modification and NF-κB signaling

Communications Biology
In the present study, a new type of Caspase-1 homolog is identified from Crassostrea gigas (defined as CgCas1-2D). It is composed of 2×DSRM-CASc domain and has closer evolutionary relationship with mammalian Caspase-1s.
Renle Chang, Jiejie Sun, Jinyuan Leng, Zihan Wang, Shuyi Mu, Yinan Li, Jie Wang, Linsheng Song   +7 more
semanticscholar   +1 more source

IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma

Cell Death and Disease
Tyrosine kinase inhibitors (TKIs) are the standard treatment for advanced hepatocellular carcinoma (HCC). However, their therapeutic efficacy is often limited by drug resistance, primarily driven by tumoral intrinsic mechanisms.
Xiaoxiao Li, Fujia Lu, Jie Zhou, Xiong Li, Yan Li, Weijie Ye, Jing Li, Liguo Yang, Shi Tang, Yuhan Zhou, Songlin Yin, Yuan Gao, Haotian Shang, Tengfei Chao, Xiang Cheng, Qian Chu, Weimin Wang   +16 more
semanticscholar   +1 more source

Cisplatin promotes pyroptosis of gastric cancer cells by activating GSDME

2023
ABSTRACTAccording to studies, numerous chemotherapeutic drugs can facilitate programmed cell death via pyroptosis. Clarifying the mechanism by which cisplatin kills gastric cancer cells is crucial for enhancing gastric cancer’s sensitivity to chemotherapy and elucidating the mechanism of drug resistance in gastric cancer.
Xianglai Jiang, Yongfeng Wang, Chenyu Wang, Haizhong Ma, Miao Yu, Hui Cai   +5 more
openaire   +1 more source

Cathepsin L Promotes Pulmonary Hypertension via BMPR2/GSDME-Mediated Pyroptosis

Hypertension
BACKGROUND: Pulmonary hypertension (PH) is a fatal progressive disease characterized by pulmonary endothelial injury and occlusive pulmonary vascular remodeling. Lysosomal protease cathepsin L degrades essential molecules to participate in the human pathophysiological process. BMPR2 (bone morphogenetic protein type II receptor)
Zhouyangfan Peng, Xue-Yang Luo, Xinyi Li, Yapei Li, Yusi Wu, Yuyang Tian, Bingjie Pan, Aleksandar Petrovic, Djuro Kosanovic, Ralph Theo Schermuly, Clemens Ruppert, Andreas Günther, Zhen Zhang, Chengfeng Qiu, Ying Li, Jun Pu, Xiaohui Li, Alex F. Chen   +17 more
openaire   +2 more sources