Results 91 to 100 of about 273,251 (302)

A IMPLANTAÇÃO DA TROCA AUTOMATIZADA DE GLÓBULOS VERMELHOS (ERITROCITAFÉRESE) COMO MODALIDADE DE TRATAMENTO EM PACIENTES COM DOENÇA FALCIFORME: EXPERIÊNCIA DO AMBULATÓRIO TRANSFUSIONAL SERUM CENTRO – RJ

Hematology, Transfusion and Cell Therapy
Introdução: A Doença Falciforme (DF) é uma doença genética e hereditária caracterizada por uma mutação no gene que produz a hemoglobina (HbA), fazendo surgir uma hemoglobina mutante denominada S (HbS).
PG Moura, MS Simão, LA Nunes, RL Lima, L Avelar, FN Lima, PCP Grossi, IG Claudio, F Akil   +8 more
doaj   +1 more source

GSH‐Responsive Nanoparticles Enhance Hepatocellular Carcinoma Immunotherapy Through Synergistic Effects of Cuproptosis and PI3K Inhibitor Combination

Advanced Science, EarlyView.
ABSTRACT Cuproptosis, an emerging form of programmed cell death, is capable of inducing mitochondrial dysfunction. Moreover, the PI3K‐AKT‐mTOR signaling pathway contributes to tumor cell progression by reprogramming mitochondrial morphology and function.
Lei Wu, Jintong Na, Xiyu Liu, Dongsheng Tang, Zhungang Yang, Zheng Cao, Xinyue He, Haihua Xiao, Liping Zhong, Yuan Liao, Yongxiang Zhao   +10 more
wiley   +1 more source

Experimental inhibition of a key cellular antioxidant affects vocal communication [PDF]

, 2017
1. There is substantial interest of evolutionary ecologists in the proximate mechanisms that modulate vocal communication. In recent times, there has been growing interest in the role of oxidative stress as a mediator of avian song expression. 2.
Feare C.J., Griffith O.W., Griffith O.W., Halliwell B.H., Koren L., Messina S., R Core Team, Spencer K.A.   +7 more
core   +3 more sources

N, S Co‐Doped Carbon Quantum Dots‐Riboflavin Composite Photosensitizers for Enhanced Iontophoresis‐Assisted Corneal Cross‐Linking

Advanced Science, EarlyView.
This study explores the use of N, S co‐doped carbon quantum dots (NS‐CQDs) as carriers for riboflavin, creating NS‐CQDs‐RF composite photosensitizers. These composites improve riboflavin absorption, enhance ROS generation efficiency, and preserve corneal epithelium integrity.
Tinghong Xu, Yong Liu, Wenjing Zhang, Qiuruo Jiang, Yi Jin, Liangzheng Lin, Lumeng Wang, Zhanhao Gu, Mimi Lin, Shihao Chen   +9 more
wiley   +1 more source

CAPITAL SOCIAL DE DOADORES DE GRANULÓCITOS: RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: A transfusão de granulócitos é uma modalidade terapêutica útil ao controle de infecções bacterianas ou fúngicas em pacientes neutropênicos, viável quando há colapso terapêutico com fármacos.
RE Almeida, KA Motta, PG Moura, L Avelar, T Martinscarvalho, LP Leandro, JAR Billo, F Akil   +7 more
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. [PDF]

, 2014
Plants and seeds are the main dietary sources of zinc, iron, manganese, and copper, but are also the main entry point for toxic elements such as cadmium into the food chain. We report here that an Arabidopsis oligopeptide transporter mutant, opt3-2, over-
Akmakjian, Garo Z, Demoin, Dustin Wayne, Jobe, Timothy O, Jurisson, Silvia S, Mendoza-Cózatl, David G, Patel, Ami, Schroeder, Julian I, Song, Lihui, Stacey, Gary, Stacey, Minviluz G, Xie, Qingqing   +10 more
core   +2 more sources

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

REAÇÃO HEMOLÍTICA AGUDA APÓS TRANSFUSÃO DE PLAQUETAS ABO INCOMPATÍVEL: RELATO DE CASO

Hematology, Transfusion and Cell Therapy
Introdução: A transfusão de concentrado de plaquetas (CP) deve idealmente ser ABO-isogrupo, entretanto o uso de CP não idênticas não são incomuns devido baixa disponibilidade de todos os tipos sanguíneos e a vida-média curta de 5 dias destes ...
SMC Lira, IGP Silva, JPL Amorim, EC Ferreira, PDS Teixeira, WWV Sampaio, M Valvasori, LFF Dalmazzo   +7 more
doaj   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source