Results 11 to 20 of about 360,657 (334)

System Xc −/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

Frontiers in Pharmacology, 2022
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides.
Feng-Jiao Li, Hui-Zhi Long, Zi-Wei Zhou, Hong-Yu Luo, Shuoxi Xu, Lichen Gao   +5 more
semanticscholar   +1 more source

The Key Role of GSH in Keeping the Redox Balance in Mammalian Cells: Mechanisms and Significance of GSH in Detoxification via Formation of Conjugates

Antioxidants, 2023
Glutathione (GSH) is a ubiquitous tripeptide that is biosynthesized in situ at high concentrations (1–5 mM) and involved in the regulation of cellular homeostasis via multiple mechanisms.
Sofia K Georgiou-Siafis, A. Tsiftsoglou
semanticscholar   +1 more source

Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway

Molecular Medicine, 2023
Background Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal necrosis, distant organ involvement, or systemic reactions ...
Xingjie Wang, Tianli Shen, Jie Lian, Kai Deng, Chao Qu, Enmeng Li, Gan Li, Yiwei Ren, Zijun Wang, Zhengdong Jiang, Xuejun Sun, Xuqi Li   +11 more
semanticscholar   +1 more source

GSH‐Activated Porphyrin Sonosensitizer Prodrug for Fluorescence Imaging‐Guided Cancer Sonodynamic Therapy

Advanced Functional Materials, 2023
Sonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer to generate reactive oxygen species (ROS), is a promising form of cancer therapy with outstanding tissue penetration depth.
Caiting Deng, Meichen Zheng, Shupeng Han, Yuanjie Wang, Jingqi Xin, Omer A. Aras, Li Cheng, Feifei An   +7 more
semanticscholar   +1 more source

Lipid peroxidation and ferroptosis: The role of GSH and GPx4.

Free Radical Biology & Medicine, 2020
Ferroptosis (FPT) is a form of cell death due to missed control of membrane lipid peroxidation (LPO). According to the axiomatic definition of non-accidental cell death, LPO takes place in a scenario of altered homeostasis.
F. Ursini, M. Maiorino
semanticscholar   +1 more source

Exogenous ABA Enhances the Antioxidant Defense System of Maize by Regulating the AsA-GSH Cycle under Drought Stress

Sustainability, 2022
When drought occurs during the maize-filling period, the probability of yield decline increases. Abscisic acid (ABA) plays a regulatory role in physiological and metabolic activities during plant development. However, its effect on the antioxidant system
Zizhu Jiang, Hengguang Zhu, Hanyu Zhu, Yuzhao Tao, Changzhuang Liu, Jiaqi Liu, Fuqiang Yang, Ming Li   +7 more
semanticscholar   +1 more source

PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma

Cell Death and Disease, 2022
Effective strategies for hepatocellular carcinoma, which is the second leading cause of death worldwide, remain limited. A growing body of emerging evidence suggests that ferroptosis activation is a novel promising approach for the treatment of this ...
Xiaomeng Hu, Yuchao He, Zhiqiang Han, Wei Liu, Dongming Liu, Xihao Zhang, Lu Chen, L. Qi, Liwei Chen, Yi Luo, Qiang Li, Peng Chen, Qiang Wu, Xiaolin Zhu, Hua Guo   +14 more
semanticscholar   +1 more source

RECUPERAÇÃO DE SANGUE INTRAOPERATÓRIA EM CIRURGIA DE REVASCULARIZAÇÃO DO MIOCÁRDIO

Hematology, Transfusion and Cell Therapy, 2023
A Cirurgia de Revascularização do Miocárdio (CABG) está entre os procedimentos cirúrgicos de grande porte, mais realizados mundialmente. Na última década, entretanto, teve um declínio de 30%, mesmo com evidências crescentes para apoiara eficácia e ...
SD Vieira, FCV Perini, KBL Burrata, MA Cesar, SMC Lira, FO Braga, TP Covas, N Jones, EAF Oliveira, RC Souza   +9 more
doaj   +1 more source

Trolox and ascorbic acid reduce direct and indirect oxidative stress in the IPEC-J2 cells, an in vitro model for the porcine gastrointestinal tract [PDF]

, 2015
Oxidative stress in the small intestinal epithelium is a major cause of barrier malfunction and failure to regenerate. This study presents a functional in vitro model using the porcine small intestinal epithelial cell line IPEC-J2 to examine the effects ...
De Smet, Stefaan, Degroote, Jeroen, Jennes, Karen, Michiels, Joris, Tembuyzer, Bart, Van Ginneken, Chris, Vergauwen, Hans, Wang, Wei   +7 more
core   +12 more sources

A FERRAMENTA DE PESQUISA DE SATISFAÇÃO COMO ESTRATÉGIA NA GESTÃO DA PERFORMANCE E FIDELIZAÇÃO DOS HOSPITAIS ATENDIDOS NA REGIONAL RIO DE JANEIRO

Hematology, Transfusion and Cell Therapy, 2023
Introdução: A Pesquisa de Satisfação é uma ferramenta que visa identificar e compreender os anseios dos seus clientes a fim de entregar, satisfazer e manter um exímio relacionamento. Objetivo: Gerenciar a satisfação e fidelização dos hospitais em relação
LFF Dalmazzo, RC Trabanca, TS Claudio, VM Oliveira, ACC Cordon, AJM Mira, T Araujo, L Purchio, BLF Abreu   +8 more
doaj   +1 more source