Results 131 to 140 of about 16,343,665 (315)

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

Angewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl, Marcel Mülbaier, Francesca Grisoni, Dirk Trauner, Marcel Bermúdez, Clemens Dialer, David B. Konrad   +6 more
wiley   +1 more source

PB2203: INCIDENCE AND PREVALENCE OF MYELOFIBROSIS IN GERMANY: A RETROSPECTIVE CLAIMS DATA ANALYSIS

HemaSphere, 2023
Sophia Junker, Alexander Slowley, Joachim Göthert, Tim D’estrube, Kelesitse Phiri, Martin Krammer, Lena Sofie Weinmann, Florian Karl, Suzanne Landi, Sabrina Müller, Boris Gorsh   +10 more
doaj   +1 more source

Involvement of 5-Hydroxytryptamine Receptor 2A in the Pathophysiology of Medication-Overuse Headache

Journal of Pain Research, 2021
Zhenyang Zheng,1 Xiaolei Shi,2 Yue Xiang,3 Aiwu Zhang,2 Yannan Fang2 1Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital, Sun Yat ...
Zheng Z, Shi X, Xiang Y, Zhang A, Fang Y
doaj  

Real-world patient characteristics and survival outcomes in patients with advanced or recurrent endometrial cancer in England: a retrospective, population-based study

BMJ Open
Objective This study defined a retrospective cohort of patients in England with primary advanced or recurrent (A/R) endometrial cancer (EC) who may have been eligible for clinical trials evaluating immune checkpoint inhibitors (ICIs) in the first-line ...
Clare Pearson, Susana Banerjee, Kiera Heffernan, Tameera Rahman, Jamie Garside, Alvaro Ingles Russo Garces   +5 more
doaj   +1 more source

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation [PDF]

, 2003
Lilia Topol, Xueyuan Jiang, Hosoon Choi, Lisa Garrett‐Beal, Peter J. Carolan, Yingzi Yang   +5 more
openalex   +1 more source

Metagenomics or Metataxonomics: Best Practice Methods to Uncover the Sinus Microbiome

International Forum of Allergy &Rhinology, EarlyView.
Isabella Burdon, George Bouras, Kevin Fenix, Kenny Yeo, James Connell, Clare Cooksley, Emma Barry, Sarah Vreugde, Peter J. Wormald, Alkis J. Psaltis   +9 more
wiley   +1 more source

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler, Jared Silver, Gerhard Wolff, Robert G. Price, Rejina Verghis, Peter F. Weller, Peter A. Merkel, Paneez Khoury, on behalf of the EGPA Mepolizumab Open‐Label Extension study group, Arnaud Bourdin, Pascal Chanez, Anoop Chauhan, Vincent Cottin, Gerald Gleich, Berhnard Hellmich, Tomonori Ishii, David Jayne, Jean‐Emmanuel Kahn, Peter Kern, Nader Khalidi, Ina Koetter, Carol Langford, Amy Markezich, Paul Monach, Shamsa Naveed, Peter Oelzner, Kenneth Pinna, Xavier Puechal, Emory H. Robinette, Florence Roufosse, Reinhard Voll, Andrew Schafer, Kaharu Sumino, Masami Taniguchi, Phillip Lieberman   +34 more
wiley   +1 more source

P964: PATIENT (PT)-REPORTED OUTCOMES IN PTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM) TREATED WITH BELANTAMAB MAFODOTIN (BELAMAF) VS POMALIDOMIDE/LOW DOSE DEXAMETHASONE (PD) IN THE DREAMM-3 STUDY

HemaSphere, 2023
Vania Hungria, Katja Weisel, Brooke Currie, Sue Perera, Neal Sule, Wei He, Astrid Mckeown, Sandhya Sapra, Linda Nelsen, Mary LI, Sophie Barale, Julia Boyle, Kaytlyn Mcpoyle, Meletios A. Dimopoulos   +13 more
doaj   +1 more source

Small Molecule GSK-3 Inhibitors Safely Promote the Proliferation and Viability of Human Dental Pulp Stem Cells-In Vitro. [PDF]

Biomedicines, 2023
Hanna S, Aly R, Eldeen GN, Adanero Velasco A, Pérez Alfayate R.   +4 more
europepmc   +1 more source

Maintenance of remission after tocilizumab withdrawal in patients with glucocorticoid‐dependent polymyalgia rheumatica

Arthritis &Rheumatology, Accepted Article.
Objective The SEMAPHORE trial evaluated the efficacy and safety of tocilizumab (TCZ) in glucocorticoid (GC)‐dependent polymyalgia rheumatica (PMR). TCZ reduced GC use and disease activity at 24 weeks. This study aimed to assess relapse rates after stopping TCZ in patients achieving remission at week 24.
Baptiste Chevet, Aghiles Souki, Emmanuel Nowak, Guillermo Carvajal‐Alegria, Emmanuelle Dernis, Christophe Richez, Marie‐Elise Truchetet, Daniel Wendling, Eric Toussirot, Aleth Perdriger, Jacques‐Eric Gottenberg, Renaud Felten, Bruno Fautrel, Anne Lohse, Laurent Chiche, Pascal Hilliquin, Catherine Le Henaff, Benjamin Dervieux, Guillaume Direz, Isabelle Chary‐Valckenaere, Divi Cornec, Dewi Guellec, Thierry Marhadour, Alain Saraux, Valérie Devauchelle‐Pensec   +24 more
wiley   +1 more source