Results 141 to 150 of about 106,875 (237)

L‐Relationship between uncertainty and average seizure frequency in clinical trials of antiseizure medications

Epilepsia, EarlyView.
Abstract Objective Antiseizure medications are approved based on clinical trials that demonstrate their efficacy as measured by reductions in seizure frequency (SF). When designing these trials, trialists must select inclusion criteria where SF can be reliably measured to maintain statistical power.
Wesley T. Kerr, Neo Kok, Katherine N. McFarlane, Advith S. Reddy, Lavanya Biju, Jacqueline A. French, Daniel M. Goldenholz   +6 more
wiley   +1 more source

Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency

Epilepsia, EarlyView.
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr, Advith S. Reddy, Neo Kok, Katherine N. McFarlane, Lavanya Biju, Jacqueline A. French   +5 more
wiley   +1 more source

GSK-3 Inhibitor Elraglusib Enhances Tumor-Infiltrating Immune Cell Activation in Tumor Biopsies and Synergizes with Anti-PD-L1 in a Murine Model of Colorectal Cancer. [PDF]

Int J Mol Sci, 2023
Huntington KE, Louie AD, Srinivasan PR, Schorl C, Lu S, Silverberg D, Newhouse D, Wu Z, Zhou L, Borden BA, Giles FJ, Dooner M, Carneiro BA, El-Deiry WS.   +13 more
europepmc   +1 more source

Trajectories of quality of life, anxiety and depressive symptomatology, and health‐related work productivity after first seizure events

Epilepsia Open, EarlyView.
Abstract Objective First seizure events are common and may exert an immediate and profound impact on people's lives. Less understood are their long‐term consequences. This prospective, longitudinal study aimed to measure and compare psychosocial and health‐related work productivity trajectories following first seizure events of various etiologies ...
Emma Foster, Zhibin Chen, Alison Conquest, David N. Vaughan, Chris Tailby, Patrick W. Carney, Wendyl D’Souza, Hue Mun Au Yong, John‐Paul Nicolo, Jacob Pellinen, Danny Liew, Terence J. O’Brien, Patrick Kwan, Zanfina Ademi   +13 more
wiley   +1 more source

GSK-3 and BCL-XL inhibition mitigates the competitive advantage of APC-mutant colorectal cancer cells. [PDF]

Oncogenesis
Zhang L, Atencia Taboada L, Baglamis S, de Kroon M, Elshout C, Ramesh P, Helderman RFCPA, Torang A, Cameron K, van Driel MS, Wouters VM, van Neerven SM, Medema JP.   +12 more
europepmc   +1 more source

Nordentatin Inhibits Neuroblastoma Cell Proliferation and Migration through Regulation of GSK-3 Pathway. [PDF]

Curr Issues Mol Biol, 2022
Boonyarat C, Boonput P, Tongloh N, Kaewamatawong R, Chaiwiwatrakul S, Yenjai C, Waiwut P.   +6 more
europepmc   +1 more source

Towards Identifying Autistic Adults at Risk for Eating Disorders: A Brief Report Into Clustering of Social Camouflaging and Sensory Processing Differences

European Eating Disorders Review, EarlyView.
ABSTRACT Background Autistic people with an eating disorder (ED) are at higher risk of poorer treatment outcomes and experiences, perhaps due to a lack of understanding surrounding underlying mechanisms. Several factors have been implicated, such as sensory processing and social camouflaging; however, there has been little empirical investigation into ...
Emy Nimbley, Siofra Bradley, Abigail Pickard, Michelle Sader, Ellen Maloney, Fhionna Moore, Tasha Suratwala, Helen Sharpe, Fiona Duffy, Karri Gillespie‐Smith   +9 more
wiley   +1 more source

Balancing Immunity: GSK-3's Divergent Roles in Dendritic Cell-Mediated T-Cell Priming and Memory Responses. [PDF]

Int J Mol Sci
Fu C, Ma T, Zhou L, Mi QS, Jiang A.
europepmc   +1 more source

Recent Perspectives on Phytochemical Profile, Pharmacological Activities, and Industrial Applications of Guava (Psidium guajava)

Food Safety and Health, EarlyView.
Psidium guajava leaves contain potent bioactive compounds like quercetin, myricetin, and triterpenoids that show antioxidant, antidiabetic, anti‐inflammatory, and anticancer effects. They act by modulating NF‐κB, PPARγ, and α‐glucosidase and by inducing apoptosis and cell cycle arrest.
Muhammad Waqar, Sehrish Jabbar, Qudrat Ullah, Farhang Hameed Awlqadr, Muhammad Tayyab Arshad, Md. Sakhawot Hossain, Sammra Maqsood, Ali Ikram, Ammar Ahmad Khan, Worawan Panpipat, Manat Chaijan   +10 more
wiley   +1 more source

Docking and structure activity relationship studies of potent and selective thiazolidinethione GSK-3 inhibitors. [PDF]

Bioorg Med Chem Lett
Boesger H, Williams K, Abdullai SA, Hubble B, Noori MS, Orac C, Amesaki DK, Ghazanfari D, Fairchild EA, Fatunbi OO, Pritchard JA, Goetz DJ, Hines JV, Bergmeier SC.   +13 more
europepmc   +1 more source