Results 181 to 190 of about 110,851 (248)

GSK3β drives early diabetic tubulopathy via TFEB‐mediated mitochondrial dysfunction

Interdisciplinary Medicine, EarlyView.
Mitochondrial dysfunction, including mitochondrial biogenesis, mitophagy, dynamics and oxidative stress, occurs in the early stages of diabetic tubulopathy, which precede proteinuria and renal histological changes. GSK3β is a potential novel biomarker for the prediction of diabetic tubulopathy.
Lan Yao, Xianhui Liang, Bingyu Li, Bohan Chen, Xiaoyang Wang, Mei Hong, Qi Feng, Yingjin Qiao, Zhangsuo Liu, Kai Wang, Pei Wang   +10 more
wiley   +1 more source

NRF2, KEAP1 and GSK-3 levels in autism spectrum disorder: a case control study. [PDF]

Int J Dev Disabil
Subasi Turgut F, Karadag M, Taysi S, Hangül Z, Gokcen C.   +4 more
europepmc   +1 more source

Dopamine Transporter Imaging‐Based Radiomics for Predicting 4‐Year Motor Progression (Unified Parkinson's Disease Rating Scale Part III) in Parkinson's Disease

iRADIOLOGY, EarlyView.
Magnetic resonance imaging (MRI)‐guided dopamine transporter (DAT) radiomics combined with machine learning showed promising performance for predicting 4‐year motor progression in Parkinson's disease. Ensemble voting fusion markedly improved discrimination compared with individual base models, with stable predictive features mainly derived from ...
Xiaoxuan Fan, Yanghan Chen, Junfeng Lin, Zenwen Han, Jianqiang Ye, Lili Lin, Hong Zhang, Ang Li, Han Jiang   +8 more
wiley   +1 more source

Human colorectal cancer: upregulation of the adaptor protein Rai in TILs leads to cell dysfunction by sustaining GSK-3 activation and PD-1 expression. [PDF]

Cancer Immunol Immunother
Montecchi T, Nannini G, De Tommaso D, Cassioli C, Coppola F, Ringressi MN, Carraro F, Naldini A, Taddei A, Marotta G, Amedei A, Baldari CT, Ulivieri C.   +12 more
europepmc   +1 more source

The imaginary divide between mental and “physical” health: Dismantling dualism and reductionism to address a monumental mistake in medicine

JCPP Advances, EarlyView.
Abstract Given the importance of the link between mental and other medical conditions, JCPP Advances organized a special issue on the topic; yet since then, very few papers have focused on this area. As such, this editorial perspective aims not only to highlight the link between mental and other medical conditions, but also to (1) explore the origins ...
Nicholas Fabiano, Marco Solmi, Kurt Kroenke, Brendon Stubbs, Joseph Firth, Fiona Gaughran, Katarzyna K. Machaczek, Christopher Palmer, Jess G. Fiedorowicz   +8 more
wiley   +1 more source

Cytoreductive Surgery in Patients With Metastatic Succinate Dehydrogenase‐Deficient Gastrointestinal Stromal Tumors

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background and Objectives Succinate dehydrogenase‐deficient (SDH‐deficient) gastrointestinal stromal tumors (GIST) are characterized by variable disease biology with poor responses to traditional tyrosine kinase inhibitors. The role of surgical intervention has been highly debated.
Katherine Y. Chen, Mark Antkowiak, Ashwyn K. Sharma, Robert Mallory, Adam M. Burgoyne, Paul T. Fanta, Jason K. Sicklick   +6 more
wiley   +1 more source

DERMACLEAR: AI‐Powered Insights Into Four Chronic Inflammatory Skin Diseases in Spain

JEADV Clinical Practice, EarlyView.
Using an AI‐enhanced analysis of electronic health records from nearly 50,000 patients, the DERMACLEAR study provides real‐world insights into the prevalence, clinical complexity, comorbidities and treatment patterns of HS, CU, PsO and AD in Spain.
Ana Giménez‐Arnau, Javier Ortiz de Frutos, Raquel Rivera‐Díaz, Lluís Puig, Jaume Notario Rosa, José Luis López‐Estebaranz, Vicente García‐Patos Briones, Ana Martín‐Santiago, José Ignacio Rojo‐Laguna, Elisabet Fernández‐Martínez, Lara Gómez‐Labrador, Esteban Daudén   +11 more
wiley   +1 more source

Regulation of GSK-3: a cellular multiprocessor.

Cell, 2001
openaire   +2 more sources

Regulatory Functions of Nilaparvata lugens GSK-3 in Energy and Chitin Metabolism. [PDF]

Front Physiol, 2020
Ding YJ, Li GY, Xu CD, Wu Y, Zhou ZS, Wang SG, Li C.   +6 more
europepmc   +1 more source

Kaempferol Attenuates Myocardial Ischemia–Reperfusion Injury by Suppressing Ferroptosis via the KEAP1–Nrf2–GPX4 Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Myocardial ischemia/reperfusion (I/R) injury is characterized by cardiomyocyte death, excessive oxidative stress, inflammation, and ferroptosis, which collectively limit the efficacy of reperfusion therapy. In this study, we investigated whether kaempferol (KAE), a natural flavonol with antioxidative and antiinflammatory properties, could ...
Yan‐Bo Zhao, Ling‐Ling Sun, Xiao‐Hua Shen, Min Wang, Mei‐Hui Wang, Lu‐Lu Liu, Kai Zhang   +6 more
wiley   +1 more source