Results 191 to 200 of about 110,851 (248)
The Laryngoscope, EarlyView.ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best +17 more
wiley +1 more source
Corticosteroid Exposure in Chronic Rhinosinusitis and Global Airway Disease: Adrenal and Bone Impact
The Laryngoscope, EarlyView.ABSTRACT Objective To investigate cumulative corticosteroid (CC) burden in patients with chronic rhinosinusitis with nasal polyps (CRSwNP), with or without coexisting asthma (global airway disease, GAD), referred for biologic treatment, and to assess the prevalence of CC‐related comorbidities, including secondary adrenal insufficiency, osteopenia and ...
Christiane Haase +7 more
wiley +1 more source
The Laryngoscope, EarlyView.The PREDICTR‐OPC model is the only prognostic classifier for oropharyngeal squamous cell carcinoma (OPSCC) that also predicts surgical outcomes. This study demonstrates that removing survivin from the model preserves its prognostic and predictive performance, with comparable discrimination, calibration, and clinical utility across training and ...
Lauren L. Zhang +18 more
wiley +1 more source
The Laryngoscope, EarlyView.Residual and recurrent disease in advanced juvenile nasopharyngeal angiofibromas (JNAs) demonstrate spontaneous involution, reduction in size, or long‐term stability following initial treatment in 95% of patients. In this systematic review of 131 patients with advanced JNA, only 2% of patients demonstrated disease progression during surveillance, but ...
Shivani Angelique Kumar +2 more
wiley +1 more source
Imposterism and Self‐Efficacy Among Canadian Otolaryngology–Head & Neck Residents: A National Survey
The Laryngoscope, EarlyView.In this national survey of Canadian OHNS residents, imposter phenomenon was highly prevalent, with nearly 80% of trainees reporting moderate to intense symptoms. Female and junior residents demonstrated significantly higher imposter scores, while greater self‐efficacy was associated with lower levels of impostorism.
Alexander C. Moise +4 more
wiley +1 more source
Molecular Carcinogenesis, EarlyView.ABSTRACT Owing to their robust antioxidant defense mechanisms, cancer stem‐like cells (CSCs) maintain a low level of oxidative stress, which is crucial for preserving stemness and pluripotency. Therefore, agents that either directly generate reactive oxygen species (ROS) or inhibit the antioxidant defense systems can selectively induce oxidative cell ...
Xueqing Liang +4 more
wiley +1 more source
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Visuospatial deficits in Parkinson's disease (PD) often precede dementia and complicate daily functioning. Alzheimer's disease (AD) pathology and α‐synuclein aggregation frequently co‐occur in PD, but their combined impact on cognition is unclear.
David Ledingham +8 more
wiley +1 more source