Results 11 to 20 of about 106,875 (237)
New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis [PDF]
PeerJ, 2023 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions and is inactivated upon stimulation. In mammals, GSK-3 includes GSK-3 α and GSK-
Shenjin Lai +3 more
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Glycogen synthase kinase-3: a new therapeutic target in mood disorders
Psychiatry and Clinical Psychopharmacology, 2021 Mood disorders, including major depressive disorder and bipolar disorder, are common and largely inadequately treated. Additionally, little is known about their etiologies.
Feyza Aricioglu, Salih Gumru
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Regulation of GSK-3 Activity as A Shared Mechanism in Psychiatric Disorders
Psychiatry and Clinical Psychopharmacology, 2021 Glycogen synthase kinase-3 (GSK-3), a member of the serine/threonine kinase family was first identified as an inhibitor of the metabolic enzyme glycogen synthase and is now accepted as a widely influential enzyme responsible for many intracellular ...
Ceren Sahin +2 more
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Cancer Biology & Therapy, 2022 GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cell function.
Andrew Hsu +11 more
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Targeting GSK3 and Associated Signaling Pathways Involved in Cancer
Cells, 2020 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was subsequently determined to have roles in multiple normal biochemical ...
Przemysław Duda +13 more
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Polarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion. [PDF]
PLoS ONE, 2013 Glioma malignancy greatly depends on its aggressive invasion. The establishment of cell polarity is an important initial step for cell migration, which is essential for cell-directional translocation.
Qifei Zou +3 more
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Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro
BMC Cancer, 2018 Background Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event free survival is very minimal.
Selvi Kunnimalaiyaan +4 more
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Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection
iScience, 2021 Summary: Glycogen synthase kinase-3 (GSK-3) is a positive regulator of PD-1 expression in CD8+ T cells and GSK-3 inhibition enhances T cell function and is effective in the control of tumor growth.
Lynette Steele +6 more
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Image Analysis and Stereology, 2020 Glycogen synthase kinase 3 (GSK-3) plays an important role in metabolic regulation in skeletal muscles, and both insulin and adrenaline stimulate GSK-3 phosphorylation. The aim of the present study was to study the effect of insulin and adrenaline on GSK-
Katja Fink +5 more
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Cells, 2021 Glycogen synthase kinase-3 (GSK-3) is a regulator of signaling pathways. KRas is frequently mutated in pancreatic cancers. The growth of certain pancreatic cancers is KRas-dependent and can be suppressed by GSK-3 inhibitors, documenting a link between ...
Stephen L. Abrams +16 more
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