Results 11 to 20 of about 121,769 (336)
GSK-3 inhibitors: preclinical and clinical focus on CNS [PDF]
Frontiers in Molecular Neuroscience, 2011 Inhibiting glycogen synthase kinase-3 (GSK-3) activity via pharmacological intervention has become an important target for treating neurodegenerative and psychiatric disorders.
Hagit eEldar-Finkelman, Ana eMartinez
doaj +4 more sources
GSK-3 inhibitors induce chromosome instability [PDF]
BMC Cell Biology, 2007 Background Several mechanisms operate during mitosis to ensure accurate chromosome segregation. However, during tumour evolution these mechanisms go awry resulting in chromosome instability.
Staples Oliver D +3 more
doaj +4 more sources
Heterocyclic GSK-3 allosteric modulators [PDF]
, 2011 [ES] La presente invención se refiere a derivados heterocíclicos de quinolinas sustituidas como inhibidores alostéricos del enzima glucógeno sintasa quinasa 3 (GSK-3).
Gil, Carmen +4 more
core +12 more sources
GSK‐3 in Neurodegenerative Diseases [PDF]
International Journal of Alzheimer’s Disease, 2011 Glycogen synthase kinase‐3 (GSK‐3) regulates multiple cellular processes, and its dysregulation is implicated in the pathogenesis of diverse diseases. In this paper we will focus on the dysfunction of GSK‐3 in Alzheimer’s disease and Parkinson’s disease. Specifically, GSK‐3 is known to interact with tau, β‐amyloid (Aβ), and α‐synuclein, and as such may
Peng Lei +3 more
+7 more sources
Lithium and Therapeutic Targeting of GSK-3. [PDF]
Cells, 2021 Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century, with purported benefit in gout, hangover, insomnia, and early suggestions that lithium improved psychiatric disorders. However, the remarkable effects of lithium reported by John Cade and subsequently by Mogens Schou revolutionized the treatment of bipolar ...
Snitow ME, Bhansali RS, Klein PS.
europepmc +5 more sources
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition. [PDF]
Proc Natl Acad Sci U S A, 2021 AbstractThe coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-19 (SARS-CoV-2), Middle East respiratory syndrome (MERS-CoV), and other coronavirus infections express a nucleocapsid protein (N) that is essential for viral replication, transcription, and virion assembly.
Liu X +18 more
europepmc +7 more sources
New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis [PDF]
PeerJ, 2023 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions and is inactivated upon stimulation. In mammals, GSK-3 includes GSK-3 α and GSK-
Shenjin Lai +3 more
doaj +2 more sources
Glycogen synthase kinase-3: a new therapeutic target in mood disorders
Psychiatry and Clinical Psychopharmacology, 2021 Mood disorders, including major depressive disorder and bipolar disorder, are common and largely inadequately treated. Additionally, little is known about their etiologies.
Feyza Aricioglu, Salih Gumru
doaj +1 more source
Regulation of GSK-3 Activity as A Shared Mechanism in Psychiatric Disorders
Psychiatry and Clinical Psychopharmacology, 2021 Glycogen synthase kinase-3 (GSK-3), a member of the serine/threonine kinase family was first identified as an inhibitor of the metabolic enzyme glycogen synthase and is now accepted as a widely influential enzyme responsible for many intracellular ...
Ceren Sahin +2 more
doaj +1 more source
GSK-3 as potential target for therapeutic intervention in cancer [PDF]
, 2014 The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes.
Abrams, Stephen L. +17 more
core +6 more sources