Results 21 to 30 of about 16,343,665 (315)
Lack of effect of mood stabilizers or neuroleptics on GSK-3 protein levels and GSK-3 activity [PDF]
The International Journal of Neuropsychopharmacology, 2003 Glycogen synthase kinase (GSK)-3 protein levels and GSK-3 activity were previously found to be over 40% reduced in the post-mortem prefrontal cortex of schizophrenic patients. Lithium and valproate have been reported to selectively inhibit GSK-3. We hypothesized that in-vivo administration of lithium and valproate would result in up-regulation of GSK-3
Nitsan Kozlovsky +3 more
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New insights into the role of GSK-3β in the brain: from neurodegenerative disease to tumorigenesis [PDF]
PeerJ, 2023 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in various tissues and organs. Unlike other kinases, GSK-3 is active under resting conditions and is inactivated upon stimulation. In mammals, GSK-3 includes GSK-3 α and GSK-
Shenjin Lai +3 more
doaj +2 more sources
Journal of Medicinal Chemistry, 2021 Based on a multitarget strategy, a series of novel tacrine-pyrimidone hybrids were identified for the potential treatment of Alzheimer's disease (AD).
Hong Yao +13 more
semanticscholar +1 more source
N-terminal Cleavage of GSK-3 by Calpain [PDF]
Journal of Biological Chemistry, 2007 Although GSK-3 activity can be regulated by phosphorylation and through interaction with GSK-3-binding proteins, here we describe N-terminal proteolysis as a novel way to regulate GSK-3. When brain extracts were exposed to calcium, GSK-3 was truncated, generating two fragments of approximately 40 and 30 kDa, a proteolytic process that was inhibited by ...
Goñi-Oliver, Paloma +3 more
openaire +4 more sources
The role of GSK‐3 in synaptic plasticity [PDF]
British Journal of Pharmacology, 2008 Glycogen synthase kinase‐3 (GSK‐3), an important component of the glycogen metabolism pathway, is highly expressed in the CNS. It has been implicated in major neurological disorders including Alzheimer's disease, schizophrenia and bipolar disorders. Despite its central role in these conditions it was not known until recently whether GSK‐3 has neuronal ...
Peineau, Stéphane +6 more
openaire +5 more sources
Cancer Biology & Therapy, 2022 GSK-3β is a serine/threonine kinase implicated in tumorigenesis and chemotherapy resistance. GSK-3β blockade downregulates the NF-κB pathway, modulates immune cell PD-1 and tumor cell PD-L1 expression, and increases CD8 + T cell and NK cell function.
Andrew Hsu +11 more
doaj +1 more source
GSK-3 and mitochondria in cancer cells [PDF]
Frontiers in Oncology, 2013 GSK-3 is a multifunctional kinase that is located in the cytosol, nucleus, and mitochondria of all cell types, and it is involved in the pathogenesis of a variety of diseases. In cancer, GSK-3 modulates the response of the cell death machinery to stress stimuli, including chemotherapeutics.
CHIARA, FEDERICA, RASOLA, ANDREA
openaire +5 more sources
Polarized regulation of glycogen synthase kinase-3β is important for glioma cell invasion. [PDF]
PLoS ONE, 2013 Glioma malignancy greatly depends on its aggressive invasion. The establishment of cell polarity is an important initial step for cell migration, which is essential for cell-directional translocation.
Qifei Zou +3 more
doaj +1 more source
Targeting GSK3 and Associated Signaling Pathways Involved in Cancer
Cells, 2020 Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was subsequently determined to have roles in multiple normal biochemical ...
Przemysław Duda +13 more
doaj +1 more source
A pivotal role of GSK-3 in synaptic plasticity [PDF]
Frontiers in Molecular Neuroscience, 2012 Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs).
Clarrisa A Bradley +13 more
openaire +4 more sources