Results 91 to 100 of about 70,328 (289)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Deciphering the evolution of composite-type GSKIP in mitochondria and Wnt signaling pathways.

PLoS ONE, 2022
We previously revealed the origin of mammalian simple-type glycogen synthase kinase interaction protein (GSKIP), which served as a scavenger and a competitor in the Wnt signaling pathway during evolution.
Cheng-Yu Tsai, Shean-Jaw Chiou, Huey-Jiun Ko, Yu-Fan Cheng, Sin-Yi Lin, Yun-Ling Lai, Chen-Yen Lin, Chihuei Wang, Jiin-Tsuey Cheng, Hsin-Fu Liu, Aij-Li Kwan, Joon-Khim Loh, Yi-Ren Hong   +12 more
doaj   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Additional file 3: Tables and Methods. of Tumor-derived CXCL5 promotes human colorectal cancer metastasis through activation of the ERK/Elk-1/Snail and AKT/GSK3β/β-catenin pathways

, 2017
Table S1, shRNA Sequences; Table S2, antibodies for immunoblot; Table S3, antibodies for immunofluorescence; Table S4, correlations between CXCL5 expression and clinical characteristics in CRC patients; Table S5, univariate and multivariate analyses of CXCL5 expression in CRC patients; Table S6, pathological stages of patients in Fig.
Jingkun Zhao, Baochi Ou, Dingpei Han, Puxiongzhi Wang, Yaping Zong, Congcong Zhu, Liu, Di, Minhua Zheng, Sun, Jing, Feng, Hao, Aiguo Lu   +10 more
openaire   +1 more source

Higher proportion of inactive Gsk3β in platelets of elderly patients with bipolar disorder: an effect of treatment?

Brazilian Journal of Psychiatry, 2013
Objective: It has been postulated that mood stabilizers inhibit glycogen synthase kinase 3-beta (Gsk3β) activity, mainly through its phosphorylation on serine-9 (Ser9).
Rodolfo Braga Ladeira, Helena Passarelli Giroud Joaquim, Leda Leme Talib, Paula Villela Nunes, Orestes Vicente Forlenza   +4 more
doaj   +1 more source

Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia

Cell Death and Disease, 2022
Hypoxia modulates senescence, but their physiological link remains unclear. Here, we found that eIF4E2, a hypoxia-activated translation initiation factor, interacted with GSK3β to maintain phosphorylation of p53, thus resisting senescence under hypoxia ...
Lei Sun, He Yang, Dong He, Jian Chen, Zhiqiang Dong, Shaoxiang Luo, Huiting Liang, Yu Cao, Bingcheng Cai, Min Zhang   +9 more
doaj   +1 more source

Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells [PDF]

, 2013
Breast cancer is the most common female cancerous disease and the second most cause of cancer death in women. About 20-30% of these tumors exhibit an amplification of the HER2/ErbB2 receptor, which is coupled to a more aggressive and invasive growth of ...
Brobeil, Alexander, Dietel, Eric, Gattenloehner, Stefan, Tag, Claudia, Wimmer, Monika   +4 more
core   +3 more sources

DHCR24 Knock-Down Induced Tau Hyperphosphorylation at Thr181, Ser199, Thr231, Ser262, Ser396 Epitopes and Inhibition of Autophagy by Overactivation of GSK3β/mTOR Signaling

Frontiers in Aging Neuroscience, 2021
Accumulating evidences supported that knock-down of DHCR24 is linked to the pathological risk factors of AD, suggesting a potential role of DHCR24 in AD pathogenesis.
Xiaojing Bai, Junfeng Wu, MengQi Zhang, Yixuan Xu, Lijie Duan, Kai Yao, Jianfeng Zhang, Jimei Bo, Yong-fei Zhao, Guoxiong Xu, Heng-bing Zu   +10 more
semanticscholar   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]

, 2017
Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco, Bordin, Antonella, Carrizzo, Albino, Chimenti, Isotta, DE FALCO, Elena, Forte, Maurizio, Frati, Giacomo, Nocella, Cristina, Pagano, Francesca, Palmerio, Silvia, Schiavon, Sonia, Schirone, Leonardo, Sciarretta, Sebastiano, Valenti, Valentina, Vecchione, Carmine, Yee, Derek   +15 more
core   +6 more sources