Results 111 to 120 of about 70,328 (289)
Journal of Cellular and Molecular Medicine, 2020 Astaxanthin (ATX), which is the most abundant flavonoid in propolis, has previously shown neuroprotective properties against cerebral ischaemia‐induced apoptosis. However, the mechanisms by which ATX mediates its therapeutic effects are unclear.
Jie Zhang +3 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan +12 more
wiley +1 more source
GSK3β inhibition promotes synaptogenesis in Drosophila and mammalian neurons. [PDF]
PLoS ONE, 2015 The PI3K-dependent activation of AKT results in the inhibition of GSK3β in most signaling pathways. These kinases regulate multiple neuronal processes including the control of synapse number as shown for Drosophila and rodents.
Germán Cuesto +5 more
doaj +1 more source
Amyloid β redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade
Alzheimer's & Dementia, 2020 Strong genetic and experimental evidence indicates toxic amyloid β (Aβ) peptides as a key driving factor of Alzheimer’s disease (AD) pathogenesis. The microtubule‐associated protein tau is an essential mediator of Aβ toxicity.
Qin Wang
semanticscholar +1 more source
Advanced Science, EarlyView.This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang +12 more
wiley +1 more source
S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner
Scientific Reports, 2022 S-SCAM/MAGI-2 gene duplication is associated with schizophrenia (SCZ). S-SCAM overexpression in the forebrain induces SCZ-like phenotypes in a transgenic (Tg) mouse model.
Gillian Kearney +4 more
doaj +1 more source
The role of the Bmi1-GSK3β pathway in glioblastoma
, 2010 Malignant gliomas remain one of the deadliest of all cancers despite maximal therapy. They present unique challenges to therapy with a median survival of 12 months. Simultaneous activation of several growth promoting and anti-apoptotic pathways represents the basis for the failure of monotherapies against this disease. In order to efficiently block
openaire +3 more sources
Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. [PDF]
, 2014 BackgroundAlzheimer's Disease (AD) and Fronto temporal lobar dementia (FTLD) are common causes of dementia in the aging population for which limited therapeutical options are available. These disorders are associated with Tau accumulation.
Adame, Anthony +10 more
core +2 more sources
Cell Death and Disease, 2020 Activating mutations of epidermal growth factor receptor (EGFR) play crucial roles in the oncogenesis of human non-small cell lung cancer (NSCLC). By screening 79 commercially available natural products, we found that the natural compound deguelin ...
F. Gao +6 more
semanticscholar +1 more source
Advanced Science, EarlyView.Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu +20 more
wiley +1 more source