EPS8L3 promotes pancreatic cancer proliferation and metastasis by activating GSK3B [PDF]
Journal of Medical Biochemistry, 2023 Background: We intended to investigate the role and regulatory mechanism of EPS8L3 in increase the development of pancreatic cancer (PC). Methods: In order to analyze the relationship between EPS8L3 level and clinicopathological indicators of PC patients,
Fan Zun +4 more
doaj +5 more sources
LINC00908 Inactivates Wnt/β‐Catenin Signaling Pathway to Inhibit Prostate Cancer Cell Stemness via Upregulating GSK3B and FBXW2 [PDF]
Cancer MedicineBackground Chemotherapy and androgen‐deprivation treatment are the curative approaches utilized to suppress prostate cancer (PCa) progression. However, drug resistance and metastasis are extensive and hard to overcome even though remarkable progress has ...
Han Guan +8 more
doaj +5 more sources
GSK3B inhibition reduced cervical cancer cell proliferation and migration by modulating the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition [PDF]
Brazilian Journal of Medical and Biological ResearchPrevious studies show that glycogen synthase kinase 3β (GSK3B) plays an important role in tumorigenesis. However, its role in cervical cancer is unclear.
Yanhong Zheng +9 more
doaj +3 more sources
MicroRNA‐214‐3p facilitates M2 macrophage polarization by targeting GSK3B [PDF]
Kaohsiung Journal of Medical Sciences, 2022 Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa. M2 macrophage polarization can reduce inflammation and repair tissue injury during AR development.
Ling‐Yan Peng +3 more
doaj +4 more sources
Cloning and sequence analysis of goat GSK3B gene and its effect on lipogenesis in goat intramuscular adipocytes [PDF]
Journal of Applied Animal ResearchThe aim of this study was to detect the expression of GSK3B gene in different tissues of goats and the expression level of intramuscular precursor adipocytes at different differentiation periods, and to further reveal the effects of overexpression and ...
Chengsi Gong +9 more
doaj +3 more sources
EPHB1 Protein Promoted the Progression of Prostate Adenocarcinoma Through Phosphorylating GSK3B and Activating EPHB1-GSK3B-SMAD3 Pathway. [PDF]
Hum MutatBackground: The apoptosis affected the prostate adenocarcinoma (PRAD); we aimed to explore the potential pathogenesis of high-risk patients based on the apoptosis features.
Xu B, Lin S, Yang K.
europepmc +3 more sources
Diabetes, Metabolic Syndrome and ObesityHongchao Shang, Tianyu Wang, Daoran Pang, Yue Qi, Lu Liu, Yifei Wang, Yan Gao Institute of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, People’s Republic of ChinaCorrespondence: Yan Gao, Institute of Pharmacy, Shandong ...
Shang H +6 more
doaj +3 more sources
Regulation of endogenous dsRNA by GSK3b in CD8 cells 4129 [PDF]
The Journal of ImmunologyGlycogen Synthase Kinase 3b (GSK3b) is a constitutively active kinase that is ubiquitously expressed and promotes cell death. Inactivation of GSK3b is tonically required to support cell survival.
Qian Fang +2 more
semanticscholar +3 more sources
eIF4A3 regulates the TFEB-mediated transcriptional response via GSK3B to control autophagy [PDF]
Cell Death & Differentiation, 2021 During autophagy, the coordinated actions of autophagosomes and lysosomes result in the controlled removal of damaged intracellular organelles and superfluous substrates. The evolutionary conservation of this process and its requirement for maintaining cellular homeostasis emphasizes the need to better dissect the pathways governing its molecular ...
Despoina Sakellariou +9 more
semanticscholar +5 more sources
GSK3B induces autophagy by phosphorylating ULK1 [PDF]
Experimental & Molecular Medicine, 2021 Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian homolog of the yeast kinase Atg1, has an essential role in autophagy induction. In nutrient and growth factor signaling, ULK1 activity is regulated by various posttranslational modifications ...
Hye Young Ryu +15 more
semanticscholar +4 more sources