Results 101 to 110 of about 24,495 (318)

Lysophosphatidic Acid Induces Migration of Human Lung‐Resident Mesenchymal Stem Cells Through the β‐Catenin Pathway [PDF]

, 2012
Mesenchymal stem cells (MSCs) have been demonstrated to reside in human adult organs. However, mechanisms of migration of these endogenous MSCs within their tissue of origin are not well understood.
Anliker, Badri, Badri, Belperio, Bienz, Bruno, Bullions, Castelino, Cheon, Contos, Fukushima, Haegel, Harris, Hoogduijn, Hoyles, Huelsken, Humphreys, Lai, Lam, Lama, Maeda, Maijenburg, Moolenaar, Nelson, Neth, Novak, Pradere, Pradere, Rivera, Shevtsov, Tager, Tolar, Walker, Yang   +33 more
core   +1 more source

Specific phospholipid scramblases are involved in exposure of phosphatidylserine, an “eat-me” signal for phagocytes, on degenerating axons

Communicative & Integrative Biology, 2017
Axonal degeneration is a key pathological feature of several neurological disorders. Emerging evidence has suggested a pathological connection between axonal degeneration and autophagy, a lysosomal degradation pathway.
Shuji Wakatsuki, Toshiyuki Araki
doaj   +1 more source

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Cadherin-7 enhances Sonic Hedgehog signalling by preventing Gli3 repressor formation during neural tube patterning [PDF]

, 2017
Sonic Hedgehog (Shh) is a ventrally enriched morphogen controlling dorsoventral patterning of the neural tube. In the dorsal spinal cord, Gli3 protein bound to suppressor-of-fused (Sufu) is converted into Gli3 repressor (Gli3R), which inhibits Shh-target
Kawano, Rie, Lupo, Giuseppe, Ohta, Kunimasa   +2 more
core   +1 more source

m5C RNA Methylation Primarily Affects the ErbB and PI3K–Akt Signaling Pathways in Gastrointestinal Cancer

Frontiers in Molecular Biosciences, 2020
5-Methylcytosine (m5C) is a kind of methylation modification that occurs in both DNA and RNA and is present in the highly abundant tRNA and rRNA. It has an important impact on various human diseases including cancer.
Shixin Xiang, Shixin Xiang, Yongshun Ma, Yongshun Ma, Jing Shen, Jing Shen, Yueshui Zhao, Yueshui Zhao, Xu Wu, Xu Wu, Mingxing Li, Mingxing Li, Xiao Yang, Parham Jabbarzadeh Kaboli, Parham Jabbarzadeh Kaboli, Fukuan Du, Fukuan Du, Huijiao Ji, Huijiao Ji, Yuan Zheng, Xiang Li, Jing Li, Qinglian Wen, Zhangang Xiao, Zhangang Xiao   +24 more
doaj   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Cryopreserved Human Otic Neuronal Spheroids Self‐assemble for Functional Connectivity Analysis and Long‐term Ototoxicity Evaluation

Advanced Science, EarlyView.
This study establishes a robust and reproducible protocol for generating human otic neuronal spheroids (hONS) from cryopreserved hPSC‐derived pre‐placodal ectoderm cells. These hONS further differentiate into functional SGN‐like neurons, which extend neurite projections toward both murine hair cells and human cortical organoids, thereby forming ...
Gaoying Sun, Yukai Wang, Man Wang, Xinyue Wang, Mingming Tang, Da Li, Jianhuan Qi, Xue Wang, Shujuan Sun, Lei Chen, Weibin An, Ligang Kong, Anqi Suo, Haibo Wang, Wenwen Liu, Lei Xu   +15 more
wiley   +1 more source

Pathological progression induced by the frontotemporal dementia-associated R406W tau mutation in patient-derived iPSCs [PDF]

, 2019
Mutations in the microtubule-associated protein tau (MAPT) gene are known to cause familial frontotemporal dementia (FTD). The R406W tau mutation is a unique missense mutation whose patients have been reported to exhibit Alzheimer\u27s disease (AD)-like ...
et al,, Karch, Celeste M, Nakamura, Mari
core   +1 more source

Successful reprogramming of epiblast stem cells by blocking nuclear localization of β-catenin. [PDF]

, 2014
Epiblast stem cells (EpiSCs) in mice and rats are primed pluripotent stem cells (PSCs). They barely contribute to chimeric embryos when injected into blastocysts.
Hayama, Tomonari, Masaki, Hideki, Murayama, Hideyuki, Nakauchi, Hiromitsu, Sato, Hideyuki, Yamaguchi, Tomoyuki   +5 more
core   +2 more sources

Synergistic Effect between the APOE ε4 Allele with Genetic Variants of GSK3B and MAPT: Differential Profile between Refractory Epilepsy and Alzheimer Disease

International Journal of Molecular Sciences
Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder characterized by recurrent focal seizures originating in the temporal lobe. Despite the variety of antiseizure drugs currently available to treat TLE, about 30% of cases continue to have ...
Danira Toral-Rios, P. Pichardo-Rojas, Elizabeth Ruiz-Sánchez, Óscar Rosas-Carrasco, R. Carvajal-García, Dey Carol Gálvez-Coutiño, Nancy Martínez-Rodríguez, Ana Daniela Rubio-Chávez, Myr Alcántara-Flores, Arely M López-Ramírez, Alma Rosa Martínez-Rosas, Á. Ruiz-Chow, Mario Alonso-Vanegas, V. Campos-Peña   +13 more
semanticscholar   +1 more source