Results 11 to 20 of about 24,495 (318)
GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1. [PDF]
J Clin InvestResistance to genotoxic therapies remains a major contributor to tumor recurrence and treatment failure, yet the mechanisms by which cancer cells escape these therapies through DNA damage response (DDR) activation are not fully understood.
Allam HS +4 more
europepmc +2 more sources
GSK3B (glycogen synthase kinase 3 beta) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on GSK3B (glycogen synthase kinase 3 beta), with data on DNA, on the protein encoded, and where the gene is implicated.
DK Thotala, EM Yazlovitskaya
openalex +4 more sources
Nicotinic augmentation of anti-inflammatory GSK3b signaling [PDF]
Tobacco Induced Diseases, 2014 Background Glycogen synthesis kinase 3b (GSK3b) has been shown to be a critical mediator of the intensity and direction of the innate immune system responding to bacterial stimuli. Stimulation of the anti-cholinergic anti-inflammatory system by tobacco alkaloids (nicotine; cotinine) leads to phosphorylation and inactivation of GSK3b and, subsequently ...
David A. Scott +3 more
openalex +2 more sources
GSK3A is redundant with GSK3B in modulating drug resistance and chemotherapy-induced necroptosis. [PDF]
PLoS ONE, 2014 Glycogen Synthase Kinase-3 alpha (GSK3A) and beta (GSK3B) isoforms are encoded by distinct genes, are 98% identical within their kinase domain and perform similar functions in several settings; however, they are not completely redundant and, depending on
Emanuela Grassilli +7 more
doaj +3 more sources
BMC Endocrine DisordersThe role of genetic susceptibility in early warning and precise treatment of diabetic kidney disease (DKD) requires further investigation. A case-control study was conducted to evaluate the predictive effect of GSK3B genetic polymorphisms on the ...
Jinfang Song +8 more
doaj +2 more sources
Amiodarone Induces Overexpression of Similar to Versican b to Repress the EGFR/Gsk3b/Snail Signaling Axis during Cardiac Valve Formation of Zebrafish Embryos. [PDF]
PLoS ONE, 2015 Although Amiodarone, a class III antiarrhythmic drug, inhibits zebrafish cardiac valve formation, the detailed molecular pathway is still unclear. Here, we proved that Amiodarone acts as an upstream regulator, stimulating similar to versican b (s-vcanb ...
Hung-Chieh Lee +9 more
doaj +3 more sources
Lithium reduces Gsk3b mRNA levels: implications for Alzheimer Disease
European Archives of Psychiatry and Clinical Neuroscience, 2008 There is evidence of increased systemic expression of active GSK3B in Alzheimer's disease patients, which apparently is associated with the formation of senile plaques and neurofibrillary tangles. Due to its central role in the pathogenesis of AD, GSK3B is currently a promising target of the pharmaceutical industry.
Camila T. Mendes +6 more
openalex +3 more sources
European Journal of Medical ResearchIron metabolism disorders are implicated in the pathogenesis of Alzheimer’s disease (AD). It was previously reported that transferrin receptor (TFR1) expression was upregulated in AD mouse model.
Tao Kang +3 more
doaj +2 more sources
miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation
Scientific ReportsThe aim of this study was to identify angiogenic microRNAs (miRNAs) that could be used in the treatment of hindlimb ischemic tissues. miRNAs contained in extracellular vesicles (EVs) deriving from the plasma were analyzed in C57BL/6 mice, which have ...
Koji Ueno +7 more
doaj +2 more sources