Results 201 to 210 of about 24,495 (318)

Microgravity-Induced Transcriptome Adaptation in Mouse Paraspinal longissimus dorsi Muscle Highlights Insulin Resistance-Linked Genes [PDF]

, 2017
Blottner, Dieter, Ciciliot, Stefano, Furlan, Sandra, Gambara, Guido, Gunga, Hanns Christian, Gutsmann, Martina, Salanova, Michele, Schiffl, Gudrun, Ungethuem, Ute, Volpe, Pompeo   +9 more
core   +1 more source

GLP1 protects cardiomyocytes from palmitate-induced apoptosis via Akt/GSK3b/b-catenin pathway [PDF]

, 2015
Ying Ying, Huazhang Zhu, Zhen Liang, Xiaosong Ma, Shiwei Li   +4 more
openalex   +1 more source

Pan‐cancer analysis reveals molecular signatures for predicting matrix stiffness in solid tumors

International Journal of Cancer, Volume 158, Issue 4, Page 1093-1105, 15 February 2026.
What's new? Tumor matrix stiffness plays a critical role in cancer progression, metastasis, and therapy resistance. Here, the authors leveraged tumor RNA‐seq data to identify molecular signatures of mechanical properties across various cancer types and build a computational model for predicting tumor matrix stiffness.
Gongyu Tang, Xinyi Liu, Yuanxiang Li, Yunfei Ta, Minsu Cho, Hua Li, Xiaowei Wang   +6 more
wiley   +1 more source

Dual-target mechanisms of olanzapine in bipolar disorder: a network pharmacology and molecular docking study revealing phase-specific regulation of longevity and PI3K-Akt pathways. [PDF]

BMC Psychiatry
Jiang K, Wang D, Zhang J, Li R, Jin T, Zhang G, Zhu H, Yang X, Du X.   +8 more
europepmc   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

Disclosure of Potential Therapeutic Targets in Plumbagin for Treating Osteosarcoma. [PDF]

Biomed Eng Comput Biol
Qiu R, Li X, Li Y, Yuan F, Cen Z, Huang G, Chen X, Fan C, Liang M.   +8 more
europepmc   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Potential Mechanisms of Tetramethylpyrazine in the Treatment of Traumatic Brain Injury Based on Network Pharmacology, Molecular Docking, Molecular Dynamics Simulations, and in vivo Experiments. [PDF]

Int J Gen Med
Tang L, Xu R, Wu Y, Cheng H.
europepmc   +1 more source

No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic‐induced tardive dyskinesia [PDF]

, 2019
Аnastasia Levchenko, Natalya M. Vyalova, Ivan V. Pozhidaev, Anastasiia S. Boiko, Diana Z. Osmanova, Olga Fedorenko, A. Semke, Н. А. Бохан, Bob Wilffert, A.J.M. Loonen, Svetlana А. Ivanova   +10 more
openalex   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source