Results 211 to 220 of about 24,495 (318)

Inhibition of TGF-beta signaling protects from alpha-synuclein induced toxicity. [PDF]

Cell Death Discov
Chua OWH, Duan L, Bothe SH, Evsyukov V, Moebius C, Bickle M, Höglinger GU, Höllerhage M.   +7 more
europepmc   +1 more source

Lifespan‐Extending Endogenous Metabolites

Aging Cell, Volume 25, Issue 2, February 2026.
Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley   +1 more source

Syndrome Differentiation and Treatment of Psoriasis by Traditional Chinese Medicines: An Integrating Study of Multi-Omics Analysis and Experimental Validation. [PDF]

J Inflamm Res
Li C, Chen K, Qiao Y, Wu P, Chen C, Zhou L, Yang Y, Zhang J, Liu N, Shen C, Zhang G, Wang D, Gu J.   +12 more
europepmc   +1 more source

Network Pharmacology and Experimental Evidence Reveal Dioscin Suppresses Proliferation, Invasion, and EMT via AKT/GSK3b/mTOR Signaling in Lung Adenocarcinoma

, 2020
Wenjing Mao, Hongwei Yin, Wenhan Chen, Tong Zhao, Sanlan Wu, Jin H, Dirk U. Bellstedt, Tan Y, Rui Zhang, Yi He   +9 more
openalex   +1 more source

Upregulation of GPNCA is associated with poor prognosis through enhancement of tumor growth via regulating GSK3B [PDF]

, 2020
Weijie Liao, Fuhai Liu, Haowei Zhang, Weifang Liao, Naihan Xu, Weidong Xie, Yaou Zhang   +6 more
openalex   +1 more source

Can Environmental Enrichment Mitigate Cell Apoptosis in the Central Nervous System Under Adverse Health Conditions? A Systematic Review

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT To summarize the available evidence in the literature regarding the effects of exposure to an enriched environment (EE) on the modulation of apoptotic markers in central tissue of rodents under unfavorable conditions. Searches were conducted in three databases: PubMed/Medline (70 articles), Scopus (65 articles), and EMBASE (128 articles), all ...
Matheus Santos de Sousa Fernandes, Diorginis José Soares Ferreira, Fatma Hilal Yagin, Georgian Badicu, Gabriela Carvalho Jurema Santos, Maria Carolina Santos Guedes, Fabrício Oliveira Souto, Luca Paolo Ardigò   +7 more
wiley   +1 more source

Identification of ferroptosis-related therapeutic targets and causal risk factors in aortic dissection via multi-omics integration. [PDF]

Medicine (Baltimore)
Peng S, Liu P, Li K.
europepmc   +1 more source

MSC‐Derived Secretome and Exosomes in Dermatology: Mechanisms, Therapeutic Opportunities, and Scientific Challenges—A Narrative Review

International Journal of Dermatology, Volume 65, Issue 2, Page 257-272, February 2026.
ABSTRACT Mesenchymal stromal cells (MSCs) exert their effects primarily through paracrine signaling via soluble factors and extracellular vesicles (EVs), especially exosomes. These acellular components offer regenerative and immunomodulatory benefits with fewer safety and logistical constraints than cell‐based therapies.
Marcela da Costa Pereira Cestari, Reinaldo Falavigna Tovo, Daniela Franco Bueno   +2 more
wiley   +1 more source

Network Analysis to Identify MicroRNAs Involved in Alzheimer's Disease and to Improve Drug Prioritization. [PDF]

Biomedicines
Reyna A, Panni S.
europepmc   +1 more source

Essential meiotic structure-specific endonuclease1 (EME1) promotes malignant features in gastric cancer cells via the Akt/GSK3B/CCND1 pathway

, 2021
Zhiguo Guo, Erbo Liang, Wei Li, Leilei Jiang, Fachao Zhi   +4 more
openalex   +1 more source