Repurposing GSK3B Small Molecule Inhibitors for Refractory Lymphoid Malignancies
Blood, 2023 Background: Small molecule GSK3B inhibitors were developed for solid tumors and neurological conditions, including Alzheimer's and Parkinson disease.
Kadriye N Cosgun +20 more
semanticscholar +2 more sources
Differential MYC Phosphorylation Drives the Divergent Cholangiocyte Response to StressSummary [PDF]
Cellular and Molecular Gastroenterology and HepatologyBackground & Aims: In primary sclerosing cholangitis (PSC), some cholangiocytes undergo cell cycle arrest (senescence), whereas others proliferate (ductular reaction). Our aim was to determine the mechanisms driving this divergent response.
Steven P. O’Hara +6 more
doaj +2 more sources
Oncology ResearchBackground Patients with gastric cancer (GC) are prone to lymph node metastasis (LNM), which is an important factor for recurrence and poor prognosis of GC.
Zhengyang Zhou +8 more
openalex +2 more sources
Paclitaxel-induced neuropathy: potential association of MAPT and GSK3B genotypes [PDF]
BMC Cancer, 2014 Paclitaxel treatment produces dose-limiting peripheral neurotoxicity, which adversely affects treatment and long-term outcomes. In the present study, the contribution of genetic polymorphisms to paclitaxel-induced neurotoxicity were assessed in 21 patients, focusing on polymorphisms involved in the tau-microtubule pathway, an important target of ...
Susanna B. Park +7 more
openalex +5 more sources
Coptisine regulates PI3K/AKT pathway to block bladder cancer progression: a study based on network pharmacology, in vitro and in vivo assays [PDF]
HereditasBackground Coptisine (COP) is a natural compound extracted from Rhizoma Coptidis, and it represses the malignant biological behaviors of bladder cancer cells. However, the underlying molecular mechanism has not been fully elucidated.
Yu Xiaohui, Li Jie, Zhou Jiangqiao
doaj +2 more sources
TRAF6 inhibits colorectal cancer metastasis through regulating selective autophagic CTNNB1/β-catenin degradation and is targeted for GSK3B/GSK3β-mediated phosphorylation and degradation [PDF]
Autophagy, 2019 Aberrant CTNNB1 signaling is one of the fundamental processes in cancers, especially colorectal cancer (CRC). Here, we reported that TRAF6, an E3 ubiquitin ligase important for inflammatory signaling, inhibited epithelial-mesenchymal transition (EMT) and
Hua Wu +11 more
openalex +2 more sources
β-Sitosterol alleviates the malignant phenotype of hepatocellular carcinoma cells via inhibiting GSK3B expression [PDF]
Human CellTo explore the effects of β-Sitosterol upon hepatocellular carcinoma cell proliferation, apoptosis, migration, invasion, and epithelial–mesenchymal transition (EMT), and to investigate the underlying mechanism using network pharmacology.
Ruoyu Wang +5 more
openalex +2 more sources
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance. [PDF]
PLoS GeneticsWNT/β-catenin signaling is mediated by the transcriptional coactivator β-catenin (CTNNB1). CTNNB1 abundance is regulated by phosphorylation and proteasomal degradation, promoted by a destruction complex composed of the scaffold proteins APC and AXIN1 or ...
Joseph K McKenna +5 more
doaj +2 more sources