Results 291 to 300 of about 24,495 (318)

Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma

Cancer Gene Therapy, 2022
GSK3B is the mRNA form of glycogen synthase kinase 3 beta (GSK-3β), which is a critical repressor of Wnt/β-catenin signaling pathway and generally inhibited in cancer cells. Plenty of researches have disclosed that circular RNAs, namely circRNAs exert important functions in the progression of various human malignancies including lung adenocarcinoma ...
Ming-Chuang Zhu, Yan-Hong Zhang, P. Xiong, Xiaowu Fan, Guo-Liang Li, Ming-Chuang Zhu   +5 more
semanticscholar   +3 more sources

Inhibition of GSK3B phosphorylation improves glucose and lipid metabolism disorder.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023
Hepatic glycolipid metabolism disorder is considered as one of the key pathogenic factors for many chronic diseases. Revealing the molecular mechanism of metabolic disorder and exploring drug targets are crucial for the treatment of glucose and lipid metabolic diseases. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been reported to be associated
Zeliang Yan, Xiaojuan Cao, Shouxiang Sun, Bing Sun, Jian Gao   +4 more
semanticscholar   +3 more sources

TRPC6 Knockout Alleviates Renal Fibrosis through PI3K/AKT/GSK3B Pathway

Current Medical Science
Renal fibrosis is the ultimate pathway of various forms of acute and chronic kidney damage. Notably, the knockout of transient receptor potential channel 6 (TRPC6) has shown promise in alleviating renal fibrosis. However, the regulatory impact of TRPC6 on renal fibrosis remains unclear.In vivo, TRPC6 knockout (TRPC6-/-) mice and age-matched 129 SvEv ...
Anbang Sun, Fang Li, Lin Zhu, Xi-Xi Zeng, Min Zhu, Qing-Hua Lei, Yanhong Liao   +6 more
semanticscholar   +3 more sources

Monoallelic loss-of-function variants in GSK3B lead to autism and developmental delay

Molecular Psychiatry
De novo variants adjacent to the canonical splicing sites or in the well-defined splicing-related regions are more likely to impair splicing but remain under-investigated in autism spectrum disorder (ASD). By analyzing large, recent ASD genome sequencing cohorts, we find a significant burden of de novo potential splicing-disrupting variants (PSDVs) in ...
Senwei Tan, Qiumeng Zhang, Rui Zhan, Si Luo, Yaoling Han, Bin Yu, Candace Muss, V. Pingault, Sandrine Marlin, A. Delahaye, Sophia Peters, C. Perne, M. Kreiss, N. Spataro, J. P. Trujillo-Quintero, C. Racine, F. Tran-Mau-Them, C. Phornphutkul, Aaron D. Besterman, Julian Martinez, Xiuxia Wang, Xiaoyu Tian, Siddharth Srivastava, D. Urion, Jill A Madden, H. Saif, Michelle M. Morrow, Amber Begtrup, Xing Li, Sarah Jurgensmeyer, Peter Leahy, Shimin Zhou, Faxiang Li, Zhengmao Hu, Jieqiong Tan, Kun Xia, Hui Guo   +36 more
semanticscholar   +4 more sources

Beeinflussung der DNS Reparatur durch GSK3B und NFATc1 im Pankreaskarzinom

Zeitschrift für Gastroenterologie, 2022
G. Schmidt, U. Latif, K. Reutlinger, A. Bockelmann, K. Conrads, F. Hamdan, E. Tan, S. Mercan, M. Brunner, H. Bohnenberger, G. Salinas, P. Ströbel, S. Johnsen, E. Hessmann, V. Ellenrieder   +14 more
semanticscholar   +2 more sources

Aquaporin 1 (AQP1)/ GSK3β interactions control pulmonary arterial smooth muscle cell (PASMC) function

Physiology, 2023
Pulmonary hypertension (PH) is a complex, incurable, devastating condition, due to pathology of the pulmonary circulation. PH can be induced by hypoxia and is notable for severe wall thickening in the distal vasculature, characterized by enhanced PASMC ...
X. Yun, S. Niedermeyer, Haiyang Jiang, L. Shimoda   +3 more
semanticscholar   +1 more source

Computational Evaluation of Bioactive Compounds from Bryophyllum pinnatum as a Novel GSK3B Inhibitor in Alzheimer's Disease

Current Protoemics
Glycogen synthase kinase 3-beta (GSK3-β) is a protein that is linked to the formation of amyloid-beta (Aβ) plaques and neurofibrillary tangles, both of which are characteristic of Alzheimer's disease.
Olorunfemi Oyewole Babalola, Paul Olamide Ottu, Olufemi Adebisi Akinola, Idayat Oyinkansola Kehinde, Ayodeji Folasade Oluwatobiloba, Cecilia Oluwamodupe, Opeyemi Iwaloye, O. Elekofehinti   +7 more
semanticscholar   +1 more source

“GSK3B and schizophrenia: a case not closed” reply

Psychopharmacology, 2009
To the editor Dr. Sand and colleagues correctly point out errors in the allele assignments in our previous report (Souza et al. 2008). The table below presents corrected allele calls for the data in Tables 1 and 3 of our previous report (Souza et al. 2008). All alleles mentioned in Table 2 of our 2008 paper are allele 1 in the table below (Table 1). It
Renan P. Souza, Deborah L. Levy, James L. Kennedy   +2 more
openaire   +1 more source

GSK3B polymorphisms alter transcription and splicing in Parkinson's disease

Annals of Neurology, 2005
AbstractParkinson's disease (PD) is a neurodegenerative disorder characterized by a combination of motor symptoms. We identified two functional single nucleotide polymorphisms in the glycogen synthase kinase‐3β gene (GSK3B). A promoter single nucleotide polymorphism (rs334558) is associated with transcriptional strength in vitro in which the T allele ...
Kwok, JBJ, Hallupp, M, Loy, CT, Chan, DKY, Woo, J, Mellick, GD, Buchanan, DD, Silburn, PA, Halliday, GM, Schofield, PR   +9 more
openaire   +3 more sources

No association of GSK3β gene (GSK3B) with Japanese schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2005
AbstractSeveral lines of evidence indicate that glycogen synthase kinase‐3β (GSK3β) is one of the candidates for schizophrenia‐susceptibility factor. However, it has not been reported the association analysis between GSK3β gene (GSK3B) and Japanese schizophrenia based on linkage disequilibrium (LD).
Masashi, Ikeda, Nakao, Iwata, Tatsuyo, Suzuki, Tsuyoshi, Kitajima, Yoshio, Yamanouchi, Yoko, Kinoshita, Norio, Ozaki   +6 more
openaire   +2 more sources