Results 301 to 310 of about 24,495 (318)

A comprehensive analysis of GSK3B variation for schizophrenia in Han Chinese individuals

Asian Journal of Psychiatry, 2020
Glycogen synthase kinase-3B (GSK-3B) is thought to be involved in numerous neuronal functions and is implicated in the pathophysiology of schizophrenia. Interestingly, a functional polymorphism, rs3755557, in the GSK3B promoter region has been consistently reported to be a risk factor for schizophrenia in southwestern and northwestern Han Chinese ...
Yan, Chen, Shen, Hua, Weiping, Wang, Weixing, Fan, Wei, Tang, Yi, Zhang, Chen, Zhang   +6 more
openaire   +2 more sources

An integrated approach for herbal drugs to target GSK3B and its linkage with melanoma and type-2 diabetes

Global Journal of Basic Science
Glycogen synthase kinase-3 (GSK3) is known to be among the busiest kinase in most cells which have more than 100 known substrates. The current understanding of GSK3 regulated mechanisms are emerging topics in the actions of GSK3, particularly its ...
D. Alammari, Nawal Helmi
semanticscholar   +1 more source

Geniposide modulates GSK3β to inhibit Th17 differentiation and mitigate endothelial damage in intracranial aneurysm

Phytotherapy Research
Intracranial aneurysm (IA) is a common cerebrovascular disease. Immune system disorders and endothelial dysfunction are essential mechanisms of its pathogenesis.
Qian Zhang, Lu-Feng Shi, Rundong Chen, He-He Zhao, Cong Yu, Yi-Rong Wang, Peng Lu   +6 more
semanticscholar   +1 more source

PTML Modeling for Alzheimer's Disease: Design and Prediction of Virtual Multi-Target Inhibitors of GSK3B, HDAC1, and HDAC6.

Current Topics in Medicinal Chemistry, 2020
BACKGROUND Alzheimer's disease is characterized by a progressive pattern of cognitive and functional impairment, which ultimately leads to death. Computational approaches have played an important role in the context of drug discovery for anti-Alzheimer ...
V. V. Kleandrova, A. Speck-Planche
semanticscholar   +1 more source

Abstract 2352: GSK3b can phosphorylate Slug and modulate cancer metastasis

Cancer Research, 2011
Abstract Metastasis is a process complicated by multiple factors and genetic events. Slug, a Snail/Slug family transcription factor, promotes epithelial-mesenchymal transition (EMT), a process pivotal in development and tumor invasion and migration.
Shih-Han Kao, Wen-Long Wang, Tse-Ming Hong, Pan-Chyr Yang   +3 more
openaire   +1 more source

Selenium alleviates modafinil-induced neurobehavioral toxicity in rat via PI3K/Akt/mTOR/GSK3B signaling pathway and suppression of oxidative stress and apoptosis: in vivo and in silico study

Environmental science and pollution research international, 2023
Shaimaa A. Shehata, Eman Kolieb, Dina A. Ali, S. A. Maher, H. E. Korayem, M. A. Ibrahim, Mohamed S. Nafie, S. Ameen   +7 more
semanticscholar   +1 more source

The Expression Analyses of GSK3B, VEGF, ANG1, and ANG2 in Human Brain Microvascular Endothelial Cells Treated with the Synthetic Cannabinoid XLR-11.

Gene, 2023
Laith Naser Al-Eitan, Saif Zuhair Alahmad   +1 more
semanticscholar   +1 more source

SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.

European journal of neurology, 2011
Recent evidence suggests that variation in the SNCA, MAPT, and GSK3B genes interacts in affecting risk for Parkinson disease (PD). In the current study, we attempt to validate previously published findings, evaluating gene-gene interactions between SNCA, MAPT, and GSK3B in association with PD.Three Caucasian PD patient-control series from the United ...
Wider, C., Vilarino-Guell, C., Heckman, M.G., Jasińska-Myga, Barbara, Ortolaza-Soto, A.I., Diehl, N., Crook, J.E., Cobb, S.A., Bacon, J.A., Aasly, J.O., Gibson, J., Lynch, T., Uitti, R.J., Wszołek, Z.K., Farrer, M.J., Ross, O.A.   +15 more
openaire   +1 more source

GSK3B and schizophrenia: a case not closed

Psychopharmacology, 2009
Philipp G, Sand, Martina, Domani, Stefan, Smesny   +2 more
openaire   +2 more sources