Cyclin dependent kinase 5 (CDK5); glycogen synthase kinase 3β (GSK3B) [PDF]
Science-Business eXchange, 2013 openalex +3 more sources
Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. [PDF]
PLoS ONE, 2017 Increased risk of developing metabolic syndrome (MetS) has been associated with the circadian clock genes. In this study, we assessed whether 29 circadian clock-related genes (including ADCYAP1, ARNTL, ARNTL2, BHLHE40, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E ...
Eugene Lin +5 more
doaj +1 more source
GSK3B and MAPT polymorphisms are associated with grey matter and intracranial volume in healthy individuals. [PDF]
PLoS ONE, 2013 The microtubule-associated protein tau gene (MAPT) codes for a protein that plays an integral role in stabilisation of microtubules and axonal transport in neurons.
Carol Dobson-Stone +10 more
doaj +1 more source
Abstract 2316 Interplay among Gbg, GSK3b and microtubules and the mechanism of Neurodegeneration
Journal of Biological ChemistryDiana Olivas +2 more
openalex +3 more sources
Frontiers in Genetics, 2022 Background: Prostate cancer (PC) is a fatally aggressive urogenital cancer killing millions of men, globally. Thus, this study aims to identify key miRNAs, target genes, and drug targets associated with prostate cancer metastasis.Methods: The miRNA and ...
Thoraia Shinawi +14 more
doaj +1 more source
Molecular docking based screening analysis of GSK3B [PDF]
Bioinformation, 2019 GSK3B has been an interesting drug target in the pharmaceutical industry. Its dysfunctional expression has prognostic significance in the top 3 cause of death associated with non-communicable diseases (cancer, Alzheimer's disease and type 2 diabetes).
Ogunleye, Adewale J +3 more
openaire +2 more sources
The validation of the association between gene polymorphisms and the cytogenetic abnormalities frequency in the cohort of radiation facility employees [PDF]
, 2017 The results from the research into the association between polymorphisms of genes-candidates for individual radiosensitivity and the frequency and spectrum of cytogenetic abnormalities are analyzed.
Халюзова, М. В.
core +2 more sources
Fos co-operation with PTEN loss elicits keratoacanthoma not carcinoma due to p53/p21WAF-induced differentiation triggered by GSK3b inactivation and reduced AKT activity [PDF]
, 2008 To investigate gene synergism in multistage skin carcinogenesis, the RU486-inducible cre/lox system was employed to ablate PTEN function [K14.cre/D5PTENflx] in mouse epidermis expressing activated v-fos [HK1.fos].
Alexander, C.L. +5 more
core +1 more source
Анналы клинической и экспериментальной неврологии, 2019 Introduction. The risk of Alzheimers disease (AD) is increased with cerebral insulin resistance, which may be caused by the impaired function of the cerebrovascular system, and may also have a direct effect on -amyloid aggregation and Tau protein ...
Yana V. Gorina +4 more
doaj +1 more source
International Journal of Molecular Sciences, 2023 This study aimed to investigate the influence of genetic variants in neuroplasticity-related genes on antidepressant treatment phenotypes. The BDNF-TrkB signaling pathway, as well as the downstream kinases Akt and ERK and the mTOR pathway, have been ...
Marlene Santos +10 more
semanticscholar +1 more source