Results 51 to 60 of about 24,495 (318)

Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated-skeletal muscle insulin resistance [PDF]

, 2014
Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle
Aguirre, Antonescu, Bain, Boppart, Cancello, Cao, Carlson, Caroline P. Wheeler-Jones, Cazzolli, Chavez, Cleasby, Coll, Corraliza, de Alvaro, De Paepe, Devaraj, Diamond-Stanic, Dimopoulos, Elgazar-Carmon, Festa, Fink, Fujishiro, Gao, Griffin, Haversen, Hemi, Hevener, Hirabara, Hirosumi, Hoehn, Hommelberg, Hotamisligil, Hotamisligil, Hwang, Kadotani, Karten, Kewalramani, Kuma, Lee, Lee, Liang, Lumeng, Lumeng, Maekawa, Mark E. Cleasby, McCall, Nguyen, Nicola A. Talbot, Patel, Pillon, Pinnick, Plomgaard, Polkinghorne, Prieur, Samokhvalov, Schilling, Sell, Shi, Solinas, Storlien, Suganami, Tardif, Thong, Turner, Uysal, Varma, Weisberg, Yuan   +67 more
core   +2 more sources

Systems Biology Understanding of the Effects of Lithium on Cancer

Frontiers in Oncology, 2019
Lithium has many widely varying biochemical and phenomenological effects, suggesting that a systems biology approach is required to understand its action.
Weihao Ge, Weihao Ge, Eric Jakobsson, Eric Jakobsson, Eric Jakobsson   +4 more
doaj   +1 more source

Overexpression of YBX1 Promotes Pancreatic Ductal Adenocarcinoma Growth via the GSK3B/Cyclin D1/Cyclin E1 Pathway

Molecular Therapy: Oncolytics, 2020
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancers due to frequently late diagnosis and futile treatment. It is a crucial necessity to determine the mechanisms of PDAC.
Zhiqiang Liu, Yongfeng Li, Xiaogang Li, Jingyuan Zhao, Shihong Wu, Heshui Wu, Shanmiao Gou   +6 more
doaj   +1 more source

Association of GSK3B With Alzheimer Disease and Frontotemporal Dementia [PDF]

Archives of Neurology, 2008
Deposits of abnormally hyperphosphorylated tau are a hallmark of several dementias, including Alzheimer disease (AD), and about 10% of familial frontotemporal dementia (FTD) cases are caused by mutations in the tau gene. As a known tau kinase, GSK3B is a promising candidate gene in the remaining cases of FTD and in AD, for which tau mutations have not ...
Barbara A J, Schaffer, Lars, Bertram, Bruce L, Miller, Kristina, Mullin, Sandra, Weintraub, Nancy, Johnson, Eileen H, Bigio, Marsel, Mesulam, Martina, Wiedau-Pazos, George R, Jackson, Jeffrey L, Cummings, Rita M, Cantor, Allan I, Levey, Rudolph E, Tanzi, Daniel H, Geschwind   +14 more
openaire   +2 more sources

Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats [PDF]

, 2009
In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and ...
Giusto, Norma Maria, Salvador, Gabriela Alejandra, Uranga, Romina Maria   +2 more
core   +2 more sources

Bioinformatics analysis of miRNA and mRNA expression profiles to reveal the key miRNAs and genes in osteoarthritis

Journal of Orthopaedic Surgery and Research, 2021
Background Osteoarthritis (OA) is a chronic degenerative joint disease and the most frequent type of arthritis. This study aimed to identify the key miRNAs and genes associated with OA progression.
Pei-yan Huang, Jun-guo Wu, Jun Gu, Tie-qi Zhang, Ling-feng Li, Si-qun Wang, Minghai Wang   +6 more
doaj   +1 more source

Inhibition of Gsk3b Reduces Nfkb1 Signaling and Rescues Synaptic Activity to Improve the Rett Syndrome Phenotype in Mecp2-Knockout Mice

Cell Reports, 2018
Summary: Rett syndrome (RTT) is the second leading cause of mental impairment in girls and is currently untreatable. RTT is caused, in more than 95% of cases, by loss-of-function mutations in the methyl CpG-binding protein 2 gene (MeCP2). We propose here
Olga C. Jorge-Torres, Karolina Szczesna, Laura Roa, Carme Casal, Louisa Gonzalez-Somermeyer, Marta Soler, Cecilia D. Velasco, Pablo Martínez-San Segundo, Paolo Petazzi, Mauricio A. Sáez, Raúl Delgado-Morales, Stephane Fourcade, Aurora Pujol, Dori Huertas, Artur Llobet, Sonia Guil, Manel Esteller   +16 more
doaj   +1 more source

High Throughput FISH Screening Identifies Small Molecules That Modulate Oncogenic lncRNA MALAT1 via GSK3B and hnRNPs

Non-Coding RNA, 2023
Traditionally, small molecule-based drug discovery has mainly focused on proteins as the drug target. Opening RNA as an additional target space for small molecules offers the possibility to therapeutically modulate disease-driving non-coding RNA targets ...
Nina Zablowsky, Lydia Farack, Sven Rofall, J. Kramer, Hanna Meyer, D. Nguyen, Alexander Ulrich, B. Bader, Patrick Steigemann   +8 more
semanticscholar   +1 more source

Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Azim, Kasum, Butt, Arthur, Cantu, Claudio, Draganova, Kalina, Fischer, Bruno, Hurtado-Chong, Anahi, Raineteau, Olivier, Sommer, Lukas, Zemke, Martina   +8 more
core   +1 more source

NIN (ninein (GSK3B interacting protein)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NIN (ninein (GSK3B interacting protein)), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +1 more source