Results 61 to 70 of about 24,495 (318)

Human alveolar progenitors generate dual lineage bronchioalveolar organoids

Communications Biology, 2022
The GSK3 inhibitor CHIR99021 is required to maintain the alveolar lineage in alveolar progenitors grown in airway media or AT2 cells become plastic, with the observed effects acting outside of its role as a GSK3B inhibitor.
Karen Hoffmann, Benedikt Obermayer, Katja Hönzke, Diana Fatykhova, Zeynep Demir, Anna Löwa, Luiz Gustavo Teixeira Alves, Emanuel Wyler, Elena Lopez-Rodriguez, Maren Mieth, Morris Baumgardt, Judith Hoppe, Theresa C. Firsching, Mario Tönnies, Torsten T. Bauer, Stephan Eggeling, Hong-Linh Tran, Paul Schneider, Jens Neudecker, Jens C. Rückert, Achim D. Gruber, Matthias Ochs, Markus Landthaler, Dieter Beule, Norbert Suttorp, Stefan Hippenstiel, Andreas C. Hocke, Mirjana Kessler   +27 more
doaj   +1 more source

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation [PDF]

Nature Communications, 2015
AbstractInsufficient pancreatic β-cell mass or function results in diabetes mellitus. While significant progress has been made in regulating insulin secretion from β-cells in diabetic patients, no pharmacological agents have been described that increase β-cell replication in humans.
Shen, Weijun, Taylor, Brandon, Jin, Qihui, Nguyen-Tran, Van, Meeusen, Shelly, Zhang, You-Qing, Kamireddy, Anwesh, Swafford, Austin, Powers, Andrew F., Walker, John, Lamb, John, Bursalaya, Badry, DiDonato, Michael, Harb, George, Qiu, Minhua, Filippi, Christophe M., Deaton, Lisa, Turk, Carolina N., Suarez-Pinzon, Wilma L., Liu, Yahu, Hao, Xueshi, Mo, Tingting, Yan, Shanshan, Li, Jing, Herman, Ann E., Hering, Bernhard J., Wu, Tom, Martin Seidel, H., McNamara, Peter, Glynne, Richard, Laffitte, Bryan   +30 more
openaire   +2 more sources

Exploration of the Neuronal Subtype Specificity of an Ethanol Responsive Gene: Glycogen Synthase Kinase 3 Beta (Gsk3b) [PDF]

, 2020
Exploration of the Neuronal Subtype Specificity of an Ethanol Responsive Gene: Glycogen Synthase Kinase 3 Beta (Gsk3b) Dalton Huey, Depts. of Bioinformatics, Biology & Chemistry, A. van der Vaart, G. M. Harris, and M. F. Miles, with Dr.
Harris, G M, Huey, Dalton, MIles, M F, van der Vaart, A   +3 more
core   +1 more source

MAPT rs242562 and GSK3B rs334558 are associated with Parkinson’s Disease in central China [PDF]

, 2014
Background: Microtubule-associated protein tau (MAPT) is a neuronal protein involved in the pathogenesis of several neurodegenerative diseases including Parkinson’s Disease (PD).
Guo, Kexin, Huang, Jinsha, Lin, Zhicheng, Liu, Ling, Long, Xi, Wang, Dingan, Wang, Tao, Wang, Youpei, Wu, Jing, Wu, Ping, Xiong, Jing, Xiong, Nian, Yu, Lan, Zhai, Desheng, Zhang, Zhentao, Zhao, Ying   +15 more
core   +1 more source

Characterization of Novel Antioxidant VANL‐100 on Akt and GSK3B Protein Activity and Expression

Alzheimer's & Dementia, 2023
Strong evidence suggests antioxidant therapies modulate Akt and glycogen synthase 3 beta (GSK3B) signalling pathways–molecular mechanisms tightly correlated with the pathophysiology of Alzheimer’s disease (AD).
Julia A Pfeifer, Tarek M Saleh, Bettina E Kalisch   +2 more
semanticscholar   +1 more source

Glycogen Synthase Kinase (GSK) 3β phosphorylates and protects nuclear myosin 1c from proteasome-mediated degradation to activate rDNA transcription in early G1 cells [PDF]

, 2014
Nuclear myosin 1c (NM1) mediates RNA polymerase I (pol I) transcription activation and cell cycle progression by facilitating PCAF-mediated H3K9 acetylation, but the molecular mechanism by which NM1 is regulated remains unclear.
A Cole, A Hay-Koren, A Sarshad, A Vintermist, A-S Tseng, AA Sérandour, AC O'Sullivan, Aishe A. Sarshad, AM Al-Khouri, Anne Von Euler, Bader Al-Muzzaini, CJ Fiol, D Drygin, D Wu, Douglas Lamont, DW Young, E Cavellán, E Kinoshita, E Sanij, F Mohn, GE Zentner, I Grummt, J Grisouard, J Russell, J Ye, JR Woodgett, JR Woodgett, JR Woodgett, L Meijer, Laura Borgonovo-Brandter, LC Fuentealba, M Benavides, M Liu, M Rosner, M Welcker, MA Munoz, Martin Corcoran, N Fomproix, N Visa, Neus Visa, NG Kim, P Cohen, P de Lanerolle, P Percipalle, P Percipalle, Piergiorgio Percipalle, Raffaella Santoro, RS Jope, S Boulon, T Moss, T Tasaki, T Vincent, V Stambolic, VA Smits, VF Taelman, VV Philimonenko, VW Ding, WJ Ryves, YC Tsai   +58 more
core   +5 more sources

Highlighting the novel effects of high-intensity interval training on some histopathological and molecular indices in the heart of type 2 diabetic rats

Frontiers in Endocrinology, 2023
BackgroundType 2 diabetes is one of the most common metabolic diseases in recent years and has become an important risk factor for cardiovascular disorders.
Mohammad Rami, Samane Rahdar, Amirhoseein Ahmadi Hekmatikar, D. Maryama Awang Daud   +3 more
doaj   +1 more source

PDE3A and GSK3B as Atrial Fibrillation Susceptibility Genes in the Chinese Population via Bioinformatics and Genome-Wide Association Analysis

Biomedicines, 2023
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia, with uncovered genetic etiology and pathogenesis. We aimed to screen out AF susceptibility genes with potential pathogenesis significance in the Chinese population.
Zechen Zhou, Yu Wang, Xiaoyi Li, Yinan Zhang, Lichuang Yuan, Dafang Chen, Xue-Dong Wang   +6 more
semanticscholar   +1 more source

IGFBP-3 inhibits Wnt signaling in metastatic melanoma cells. [PDF]

, 2016
In previous works, we have shown that insulin-like growth factor-binding protein-3 (IGFBP-3), a tissue and circulating protein able to bind to IGFs, decreases drastically in the blood serum of patients with diffuse metastatic melanoma.
Londei, Paola, Martella, M, Naspi, A, Panasiti, Vincenzo, Polinari, Dorina, Rosa Alba, R, Sancillo, L, Zingariello, M   +7 more
core   +1 more source

Expression profiling of stem cell-related genes in neoadjuvant-treated gastric cancer: a NOTCH2, GSK3B and β-catenin gene signature predicts survival. [PDF]

PLoS ONE, 2012
Cancer stem cell (CSC) based gene expression signatures are associated with prognosis in various tumour types and CSCs are suggested to be particularly drug resistant.
Lukas Bauer, Rupert Langer, Karen Becker, Alexander Hapfelmeier, Katja Ott, Alexander Novotny, Heinz Höfler, Gisela Keller   +7 more
doaj   +1 more source