Results 71 to 80 of about 24,495 (318)

Insulin and IGF1 enhance IL-17-induced chemokine expression through a GSK3B-dependent mechanism: a new target for melatonin\u27s anti-inflammatory action. [PDF]

, 2013
Obesity is a chronic inflammation with increased serum levels of insulin, insulin-like growth factor 1 (IGF1), and interleukin-17 (IL-17). The objective of this study was to test a hypothesis that insulin and IGF1 enhance IL-17-induced expression of ...
Blask, David E, Brainard, George, Cecil, Kate, MS, Dauchy, Erin M, Dauchy, Robert T, Ge, Dongxia, Hanifin, John P, Hill, Steven M, Liu, Sen, Mao, Lulu, Myers, Leann, Rowan, Brian G, Xiong, Zhenggang, You, Zongbing, Zhang, Qiuyang   +14 more
core   +1 more source

Convergence of Wnt signalling on the HNF4a-driven transcription in controlling liver zonation [PDF]

, 2009
BACKGROUND & AIMS: In each hepatocyte, the specific repertoire of gene expression is influenced by its exact location along the portocentrovenular axis of the hepatic lobule and provides a reason for the liver functions compartmentalization defined ...
Alonzi, T, Amicone, Laura, Cicchini, Carla, Colletti, M, Conigliaro, Alice, Pasquini, E, Santangelo, L, Tripodi, Marco   +7 more
core   +1 more source

Study on Antidiabetic Potential of Sessuvium Portulacastrum Aqueous Extract: An In-Silico and In-Vitro Analysis

Journal of Pharmacy and Bioallied Sciences
Diabetes mellitus is a persistent metabolic condition marked by elevated blood glucose levels due to compromised insulin secretion or functionality. The search for natural antidiabetic agents has gained attention due to their potential effectiveness and ...
Mukundh S Tarun, Natarajan Sathan R, Veeraraghavan Vishnu Priya   +2 more
doaj   +1 more source

Molecular mechanisms controlling the phenotype and the EMT/MET dynamics of hepatocyte [PDF]

, 2014
The complex spatial and paracrine relationships between the various liver histotypes are essential for proper functioning of the hepatic parenchymal cells.
Fausto N, Lazarevich NL, Michelotti GA, Omenetti A, Spagnoli FM, Treyer A, Valdes F   +6 more
core   +3 more sources

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β

Cancers, 2021
Simple Summary The current obstacles for discovering new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing, the identification of new uses for approved or investigational drugs for new therapeutic ...
J. Kaushal, Rakesh Bhatia, Ranjana K. Kanchan, Pratima Raut, S. Mallapragada, Quan P. Ly, S. Batra, S. Rachagani   +7 more
semanticscholar   +1 more source

Mechanisms of Actinidia chinensis Planch in treating colon cancer based on the integration of network pharmacology, molecular docking, and experimental verification

Hereditas, 2023
Background As an anticancer Chinese herbal medicine, the effective components and mechanism of Actinidia chinensis Planch (ACP, Tengligen) in the treatment of colon cancer are still unclear.
Jin-Fang Chen, Shi-Wei Wu, Zi-Man Shi, Yan-Jie Qu, Min-Rui Ding, Bing Hu   +5 more
doaj   +1 more source

Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/β-Catenin Pathway Stimulation by Regulating GSK3b Activity

International Journal of Molecular Sciences, 2021
Adenosine is a cellular metabolite with diverse derivatives that possesses a wide range of physiological roles. We investigated the molecular mechanisms of adenosine and cordycepin for their promoting effects in wound-healing process.
Jaeyoon Kim, J. Shin, Y. Choi, So young Lee, M. Jin, C. Kim, N. Kang, Sang‐Hwha Lee   +7 more
semanticscholar   +1 more source

Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]

, 2016
Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W, Hart, Kevin C, Nelson, William James, Pruitt, Beth L, Sim, Joo Yong   +4 more
core   +2 more sources

Novel Nonphosphorylated Serine 9/21 GSK3β/a Antibodies: Expanding the Toolkit for Studying GSK3 Regulation

Frontiers in Molecular Neuroscience, 2016
Glycogen synthase kinase 3 (GSK3) and are serine/threonine kinases involved in many biological processes. A primary mechanism of GSK3 activity regulation is phosphorylation of N-terminal serine (S) residues (S9 in GSK3b, S21 in GSK3a).
Tessa Grabinski, Nicholas M Kanaan, Nicholas M Kanaan   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source