Results 1 to 10 of about 221,192 (198)

GTP-dependent inhibition of insulin secretion by epinephrine in permeabilized RINm5F cells. Lack of correlation between insulin secretion and cyclic AMP levels.

, 1988
Susanne Ullrich, Claes B. Wollheim
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Small GTP-Binding Proteins

International Review of Cytology, 1992
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and ...
Masahito Kawata, Akira Kikuchi, Kozo Kaibuchi, Yoshimi Takai   +3 more
openaire   +4 more sources

Mutation-Induced Impacts on the Switch Transformations of the GDP- and GTP-Bound K-Ras: Insights from Multiple Replica Gaussian Accelerated Molecular Dynamics and Free Energy Analysis

Journal of Chemical Information and Modeling, 2021
Mutations yield significant effect on the structural flexibility of two switch domains, SW1 and SW2, in K-Ras, which is considered as an important target of anticancer drug design.
Jianzhong Chen, Shaolong Zhang, W. Wang, Laixue Pang, Qinggang Zhang, Xinguo Liu   +5 more
semanticscholar   +1 more source

Interaction of liver plasma membranes and GTP with GTP hydrolysis

Biochemical and Biophysical Research Communications, 1973
Abstract [ 14 C]GTP or a metabolic product of GTP binds to liver membranes. Less label was associated with membranes when membranes were incubated with increasing concentrations of carrier GTP; ATP did not displace the label. Chromatography of extracted incubation mixtures of [ 14 C]GTP and membranes revealed that over 96% of the nucleotide was ...
Martin Sonenberg, Susan Scheinberg, Norbert I. Swislocki   +2 more
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Regulation of GTP biosynthesis

Advances in Enzyme Regulation, 1992
In the regulation of GTP biosynthesis, complex interactions are observed. A major factor is the behavior of the activity of IMPDH, the rate-limiting enzyme of de novo GTP biosynthesis, and the activity of GPRT, the salvage enzyme of guanylate production. The activities of GMP synthase, GMP kinase and nucleoside-diphosphate kinase are also relevant.
George Weber, Thomas Szekeres, Hiroyuki Nakamura, Yutaka Natsumeda, Masami Nagai   +4 more
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GTP-binding proteins in plants

Plant Molecular Biology, 1993
Abstract Full length cDNAs of small GTP-binding proteins were inserted into PGEM1 under the control of the T7 promotor as described previously (Chavrier et al. 1990; Huber et al. 1993). GTP-binding proteins were then transiently expressed in BHK 21 cells with the T7 RNA polymeraserecombinant vaccinia virus system (Fuerst et al.
Terryn, N., van Montagu, Marc, Inzé, Dirk   +2 more
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GTP-binding proteins in plants

Cellular and Molecular Life Sciences CMLS, 1999
GTP-binding proteins are found in all organisms. They are important switches that cycle between an active and an inactive state, ensuring vectorial flow of information on the expense of guanosine triphosphate (GTP). In this review, we discuss current progress in the molecular characterization and functional analysis of plant genes encoding ...
K. Palme, A. Molendijk, F. Bischoff, C. S. V. Rajendrakumar   +3 more
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Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.

Human Molecular Genetics, 2014
Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson's disease (PD) and contribute to sporadic PD. LRRK2 contains Guanosine-5'-triphosphate (GTP) binding, GTPase and kinase activities that have been implicated in ...
Tianxia Li, Dejun Yang, Shijun Zhong, Joseph M. Thomas, F. Xue, Jingnan Liu, Lingbo Kong, P. Voulalas, H. Hassan, Jae-Sung Park, Alexander D. MacKerell, Wanli W. Smith   +11 more
semanticscholar   +1 more source

Inhibition of erythrocyte transglutaminase by GTP

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1987
The guanine nucleotides GTP, GDP and GMP inhibit the activity of erythrocyte transglutaminase (protein-glutamine:amine gamma-glutamyltransferase, EC 2.3.2.13) in a decreasing order of effectiveness. The inhibition is more apparent at low than at saturating levels of calcium ions and is not due to the chelation of Ca2+, but to an interference with the ...
Carlo M. Bergamini, Marco Signorini, Licia Poltronieri   +2 more
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Small GTP-Binding Proteins

Physiological Reviews, 2001
Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and constitute a superfamily consisting of more than 100 members. This superfamily is structurally classified into at least five families: the Ras, Rho, Rab, Sar1/Arf, and Ran families.
Takashi Matozaki, Takuya Sasaki, Yoshimi Takai   +2 more
openaire   +3 more sources