Results 11 to 20 of about 193,264 (147)
GTP: Gatekeeper for Autophagy [PDF]
Molecular Cell, 2010 Chaperone-mediated autophagy (CMA) is involved in cellular quality control, and in the response to stress, deterioration in CMA contributes to the aging phenotype and to various disorders. The paper by Bandyopadhyay et al. in this issue of Molecular Cell demonstrates the role of GTP binding by elongation factor 1 alpha (EF1alpha) in regulating the ...
Beau, Isabelle, Codogno, Patrice
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Journal of Biological Chemistry, 2002 Because of the apparently greater conformational flexibility of yeast versus muscle actin and the ability of other members in the actin protein superfamily to efficiently use both ATP and GTP, we assessed the ability of yeast actin to function with GTP.
Kuo-Kuang, Wen +2 more
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BMC Bioinformatics, 2018 Background The endomembrane system, known as secretory pathway, is responsible for the synthesis and transport of protein molecules in cells. Therefore, genes involved in the secretory pathway are essential for the cellular development and function ...
Kumar Parijat Tripathi +2 more
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The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability
eLife, 2020 Microtubules are cytoskeletal polymers whose function depends on their property to switch between states of growth and shrinkage. Growing microtubules are thought to be stabilized by a GTP cap at their ends.
Johanna Roostalu +5 more
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Frontiers in Earth Science, 2022 Three dimensional (3D) geological model is frequently used to represent the geological conditions of the subsurface. The generalized triangular prism (GTP) model designed for borehole sampling data is a spatial data model that could retain the internal ...
Liming Sun +5 more
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Kinetic analysis of GTP hydrolysis catalysed by the Arf1-GTP-ASAP1 complex [PDF]
Biochemical Journal, 2007 Arf (ADP-ribosylation factor) GAPs (GTPase-activating proteins) are enzymes that catalyse the hydrolysis of GTP bound to the small GTP-binding protein Arf. They have also been proposed to function as Arf effectors and oncogenes. We have set out to characterize the kinetics of the GAP-induced GTP hydrolysis using a truncated form of ASAP1 [Arf GAP with ...
Ruibai, Luo +6 more
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A mant-GDP Dissociation Assay to Compare the Guanine Nucleotide Binding Preference of Small GTPases
Bio-Protocol, 2021 Small GTPases are cellular switches that are switched on when bound to GTP and switched off when bound to GDP. Different small GTPase proteins or those with mutations may bind to GTP or GDP with different relative affinities.
玉萍 tanyuping, Qingxiang Sun
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Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin
Biomolecules, 2022 Guanine nucleotides can flip between a North and South conformation in the ribose moiety. To test the enzymatic activity of GTPases bound to nucleotides in the two conformations, we generated methanocarba guanine nucleotides in the North or South ...
Kiran S. Toti +4 more
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Frontiers in Psychology, 2022 Game Transfer Phenomena (GTP) refers to a cluster of involuntary phenomena related to playing videogames, including sensory and cognitive intrusions, transient changes in perception and self-agency.
Angelica B. Ortiz de Gortari +2 more
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A GTP synthase ribozyme with increased GTP turnover. [PDF]
Proc Natl Acad Sci U S ABefore the invention of encoded protein translation, early stages of life likely relied on catalytic RNAs (ribozymes). To test how such a system could have functioned, researchers have developed ribozymes that could have provided central functions.
Han X +3 more
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