Results 171 to 180 of about 386,929 (385)

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Human Molecular Genetics, 2018
Zhiyong Liu, Nicole Bryant, R. Kumaran, A. Beilina, A. Abeliovich, M. Cookson, A. West   +6 more
semanticscholar   +1 more source

Purification, Fluorescent Labeling, and Detyrosination of Mammalian Cell Tubulin for Biochemical Assays

Cytoskeleton, EarlyView.
ABSTRACT Microtubules play essential roles in numerous cellular processes. All microtubules are built from the protein tubulin, yet individual microtubules can differ spatially and temporally due to their tubulin isotype composition and post‐translational modifications (PTMs).
Ezekiel C. Thomas, Yang Yue, Morgan L. Pimm, Takashi Hotta, Ryoma Ohi, Kristen J. Verhey   +5 more
wiley   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

rab3 is a small GTP-binding protein exclusively localized to synaptic vesicles.

, 1990
Gabriele Fischer von Mollard, Gregory A. Mignery, Marion Baumert, M S Perin, T J Hanson, P.M. Burger, Reinhard Jahn, Thomas C. Südhof   +7 more
openalex   +1 more source

Development and Characterization of a Noncovalent Stimulator of Interferon Genes Proteolysis‐Targeting Chimeras

ChemMedChem, EarlyView.
The design, synthesis, and initial biological evaluation of noncovalent stimulator of interferon genes degraders are presented. The lead from this series, BH690L, exhibits an effective concentration for half‐maximal degradation (DC50) of 11.3 nM and a maximum level of degradation (Dmax) of 0.67.
Bo Hu, Adam S. Duerfeldt
wiley   +1 more source

Membrane tethering by the atlastin GTPase depends on GTP hydrolysis but not on forming the cross-over configuration

, 2014
Simran G. Saini, Chuang Liu, Peijun Zhang, Tina H. Lee   +3 more
openalex   +1 more source

Rapid evolution in conformational space: A study of loop regions in a ubiquitous GTP binding domain [PDF]

, 2004
Christian Blouin, Davin Butt, Andrew J. Roger   +2 more
openalex   +1 more source

Unraveling Novel Genetic Determinants of Thiopurine Response Via TWAS

Clinical Pharmacology &Therapeutics, EarlyView.
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Thiopurines such as 6‐mercaptopurine (6MP) are essential in ALL maintenance therapy. However, dose‐limiting toxicities can significantly disrupt treatment. While genetic variants in TPMT and NUDT15 are known to affect thiopurine response, many patients with normal function ...
Carlotta Bidoli, Wenjian Yang, Seth E. Karol, Marianna Lucafò, Gabriele Stocco, Jun J. Yang   +5 more
wiley   +1 more source

GTP Binding Protein Gtr1 Cooperating with ASF1 Regulates Asexual Development in Stemphylium eturmiunum [PDF]

, 2022
Shi Wang, Chunyan Song, Lili Zhao, Wenmeng Xu, Zhuang Li, Xiaoyong Liu, Xiu-Guo Zhang   +6 more
openalex   +1 more source

The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

Cell, 1995
O. Coso, M. Chiariello, Jin-Chen Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, J. Gutkind   +7 more
semanticscholar   +1 more source