Results 171 to 180 of about 374,227 (387)

Beyond Histones: Unveiling the Functional Roles of Protein Acetylation in Prokaryotes and Eukaryotes

open access: yesCell Biology International, EarlyView.
ABSTRACT Lysine acetylation plays a crucial role in cellular processes and is found across various evolutionary organisms. Recent advancements in proteomic techniques revealed the presence of acetylation in thousands of non‐histone proteins. Here, we conducted extensive meta‐analysis of 48 acetylomes spanning diverse organisms, including archaea ...
Bruno Sousa Bonifácio   +6 more
wiley   +1 more source

Photocaged Dinucleoside Tetraphosphates for Light‐Mediated Activation of 5′ Cap Interactions and Translation In Vitro

open access: yesChemistryEurope, EarlyView.
Photocaged dinucleoside tetraphosphates can be incorporated into mRNA by T7 RNA polymerase. Subsequent irradiation with light activates 5′ cap interactions and translation. These 5′ cap analogs are useful tools to probe the functions of naturally occurring dinucleoside tetraphosphates and their role in bacteria and mammalian cells.
Cedrik Kühling   +5 more
wiley   +1 more source

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

open access: yesHuman Molecular Genetics, 2018
Zhiyong Liu   +6 more
semanticscholar   +1 more source

Asymmetric Total Synthesis of (−)‐Glycybridin B, a Pharmacophore Screened Candidate for Tubulin Binding

open access: yesChemistry – A European Journal, EarlyView.
Discovery and first total synthesis of (−)‐glycybridin B via a five‐step route utilizing a key chalcone intermediate. Initially identified through a pharmacophore screening as a potential tubulin binder, this natural product serves as a tool compound to explore structure‐activity relationships related to microtubule targeting and anticancer potential ...
Alice Maiocchi   +14 more
wiley   +1 more source

The PP2A‐B56 Binding Site LxxIxE Contributes to Asp‐Mediated Spindle Pole Stability

open access: yesCytoskeleton, EarlyView.
ABSTRACT The organization of microtubules into a mitotic spindle is critical for animal cell proliferation and involves the cooperation of hundreds of proteins whose molecular roles and regulation are not fully understood. The protein product of the Drosophila gene abnormal spindle, Asp, is a microtubule‐associated protein required for correct mitotic ...
Margaux Quiniou   +6 more
wiley   +1 more source

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