Results 181 to 190 of about 190,941 (249)

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

Characterization of the GTPγS release function of a G protein-coupled receptor. [PDF]

Nat Commun
Bohn LM, Stahl EL.
europepmc   +1 more source

Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Imeglimin is a novel oral hypoglycemic agent approved for the treatment of type 2 diabetes in Japan, with dual actions to enhance insulin secretion and improve insulin sensitivity, suggested by preclinical evidence. However, the effect of imeglimin on tissue‐specific insulin sensitivity and glucose kinetics using glucose tracers is ...
Tsubasa Tajima, Hideyoshi Kaga, Naoaki Ito, Toshiki Kogai, Hitoshi Naito, Saori Kakehi, Satoshi Kadowaki, Yuya Nishida, Ryuzo Kawamori, Yoshifumi Tamura, Hirotaka Watada   +10 more
wiley   +1 more source

A Rab1 interactome illuminates a dual role in autophagy and membrane trafficking. [PDF]

J Cell Biol
van Vliet AR, Gillingham AK, Morgan TE, Ohashi Y, Smith TS, Abid Ali F, Munro S.   +6 more
europepmc   +1 more source

Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1·GTP pathway

, 2009
Shang‐Yi Tsai, Teruo Hayashi, Brandon K. Harvey, Yun Wang, Wells W. Wu, Rong‐Fong Shen, Yongqing Zhang, Kevin G. Becker, Barry J. Hoffer, Tsung‐Ping Su   +9 more
openalex   +1 more source

The nucleoporin Nup60p functions as a Gsp1p–GTP-sensitive tether for Nup2p at the nuclear pore complex [PDF]

, 2001
Daniel P. Denning, Brook Mykytka, Nadia P.C. Allen, Lan Huang, A. L. Burlingame, Michael Rexach   +5 more
openalex   +1 more source

Neuronal hyperexcitability: A key to unraveling hippocampal synaptic dysfunction in Lafora disease

Epilepsia, EarlyView.
Abstract Background and Objective Lafora disease (LD) is a rare progressive disorder caused by mutations in the EPM2A or EPM2B genes, characterized by the accumulation of Lafora bodies, drug‐resistant epilepsy, and cognitive decline. To investigate the early molecular mechanisms of LD, we studied electrophysiological changes in the dentate gyrus (DG ...
Cinzia Costa, Laura Bellingacci, Jacopo Canonichesi, Valentina Imperatore, Anna Aurora Taddei, Luis Zafra‐Puerta, Nerea Iglesias‐Cabeza, Paolo Prontera, Andrea Mancini, Massimiliano Di Filippo, Alessandro Tozzi, Katiuscia Martinello, Marta Barzasi, Fabrizio Gardoni, Marina P. Sánchez, José M. Serratosa, Lucilla Parnetti, Miriam Sciaccaluga   +17 more
wiley   +1 more source

ARF: the most misunderstood GTPase I ever knew - why study ARF GAPs. [PDF]

Front Mol Biosci
Turn RE, Dacks JB, Rosenberg EM, Soubias O, Northup JK, Randazzo PA.   +5 more
europepmc   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

A special latch in yeast mitofusin guarantees mitochondrial fusion by stabilizing self-assembly. [PDF]

Nat Commun
Huang SJ, Ma DF, Yu C, Li J, Tu X, Huang Z, Qi Y, Ou JY, Feng JX, Yu B, Cao YL, Yue JX, Hu J, Li M, Lu Y, Yan L, Gao S.   +16 more
europepmc   +1 more source